Some teratological effects of difloxacin in rats

Abstract

The aim of this experiment was to detect the teratogenic effects of difloxacin in Wister Albino rats. Thirty pregnant rats were divided into 3 groups; group (1) behaved as control and received normal saline. Group (2) was administered difloxacin at a dose of 20 mg/kg b. wt and group (3) was administered difloxacin at a dose of 40 mg/kg b. wt orally once daily from 6 th to 15 th day of pregnancy. The study revealed no teratogenic effect at a dose of 20 mg/kg b. wt, while at a dose of 40 mg/kg b.wt has significant teratogenic effect showed by decrease in size, weight, length, retarded growth in fetuses, fetal resorption of treated groups, the incidences of skeletal & visceral abnormalities were increased in treated group (40 mg/kg b. wt). It could be concluded that. Administration of difloxacin during early stage of pregnancy and at high dose induce some fetal abnormalities.

Effects of norfloxacin on fetal development in pregnant female rats

“…Stahlmann [22] indicated that the administration of ofloxacin and ciprofloxacin to immature animal's induced cardiac hyperplasia. Similarly, Elkomy et al [2], AL-Myahi et al [3], Aboubakr et al [5], and El Komy et al [18] stated that the administration of both norfloxacin and difloxacin induced visceral malformation in pregnant rats.…”

“…Particular drugs can pass the placental barrier and enter the fetal circulation, induce therefore structural abnormalities in the neonate at birth extending to undefined period [2].…”

Adverse effects of moxifloxacin and flunixin meglumine and their combination on pregnant rats

“…The obtained data are supported [40] who reported that, the use of mefenamic acid revealed variable histopathological alterations as mild hepato-cellular necrosis with increased liver weight. Moreover, [38]. noticed that liver sections of piroxicam treated mice showed inflammatory cellular infiltration, vacuolated hepatocytes, dilated sinusoids, and increased number of Kupffer cells.…”

“…who reported mild interstitial nephritis associated with fluoroquinolones, norfloxacin, ciprofloxacin and nofloxacin. Also, [36][37][38]. reported that, norfloxacin showed glomerular olization in the lining epithelium of the renal tufts while the intertubular tissue showed focal hemorrhages in kidney after its oral administration.…”