Terlipressin induced ischaemia of skin

Sundriyal, Deepak; Kumar, Naveen; Patnaik, Itish; Kamble, Ulka

doi:10.1136/bcr-2013-010050

Cited by 9 publications

(5 citation statements)

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“…However, there are case reports of terlipressin causing skin necrosis and gangrene (table 1). 4–22 Nineteen articles reporting a total of 25 patients were analysed. Of these patients, 80% were male and the mean age was 58.88±12.36 years.…”

Section: Discussionmentioning

confidence: 99%

Terlipressin-induced ischaemic skin necrosis

et al. 2020

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Terlipressin is a commonly used drug in hepatology practice for the two most serious complications of cirrhosis, that is, acute oesophageal variceal bleed and hepatorenal syndrome. Acute-on-chronic liver failure (ACLF) is a medical emergency and is frequently associated with acute kidney injury (AKI). Two male patients with alcohol-induced ACLF with high MELD (Model for End-Stage Liver Disease) score presented with AKI. Both were treated with terlipressin infusion. There was no response to terlipressin in these sick patients, and further both patients developed ischaemic skin necrosis and succumbed to multiorgan failure. Continuous infusion of terlipressin is superior to bolus dosing, but we noted that continuous infusion might as well be associated with severe adverse effects in patients with a high MELD score. More extensive prospective studies, including patients with high MELD score, are required to ascertain the safety of terlipressin.

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Section: Discussionmentioning

confidence: 99%

Terlipressin-induced ischaemic skin necrosis

et al. 2020

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“…Ischaemic changes in both the lower limbs have been reported to have regressed and recovered in 2 weeks after the discontinuation of terlipressin [8]. In contrast, Coskun et al [1] reported that skin necrosis on the forearm progressed for 1 week even after terlipressin discontinuation.…”

Section: Referencesmentioning

confidence: 95%

Isolated lower limb gangrene: a caveat of terlipressin therapy

Khandelwal

Gupta

Haldar

et al. 2016

Anaesthesiol Intensive Ther

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“…Peripheral ischemia is a rare and debilitating side effect of terlipressin 1‐3 . It is reported to develop after 48‐72 hours of initial dose 1 .…”

Section: Clinical Image Casementioning

confidence: 99%

“…Peripheral ischemia is a rare and debilitating side effect of terlipressin. [1][2][3] It is reported to develop after 48-72 hours of initial dose. 1 Peripheral ischemia must be in the differentials if patients on terlipressin develop limb pains.…”

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confidence: 99%