Termination of very early pregnancy by RU 486 — An antiprogestational compound

Kovács, László; Sas, M.; B, Resch; Ugocsai, G.; Swahn, Marja‐Liisa; Bygdeman, M.; Rowe, P.J.

doi:10.1016/0010-7824(84)90014-3

Cited by 200 publications

(43 citation statements)

References 6 publications

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“…RU486, one of a group of antigestagens, has been extensively studied in laboratory animals and in women for its abortifacient properties (Kovacs et al, 1984;Neef et al, 1984;Philibert et al, 1985;Beier et al, 1986;Chwalisz and Elger, 1986;Van Look and Bygdeman, 1989;Ulmann et al, 1990). It has also been shown that daily administration at low dosages inhibits ovu¬ lation in monkeys and women (Croxatto et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Fertility control in laboratory rats and mice after feeding with the antigestagen RU486

Gao¹,

Short²

1994

Reproduction

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Section: Introductionmentioning

confidence: 99%

Fertility control in laboratory rats and mice after feeding with the antigestagen RU486

Gao¹,

Short²

1994

Reproduction

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“…However, the discovery of progesterone receptor modulators (PRMs), which are steroids with antiprogestational activity (as opposed to progestational activity), has provided a different approach to inhibition of ovulation and implantation than that utilized by current progestin-based OCs. For example, the PRM mifepristone can terminate pregnancy in women when taken orally after a missed menses, especially when combined with a prostaglandin, which progestins cannot (127). In addition, administration of 200 mg mifepristone alone on day LH plus 2 prevented pregnancy in all but 1 of 157 cycles in fertile women, resulting in a Pearl index of 7.6 (128).…”

Section: New Leads For Contraceptivesmentioning

confidence: 99%

As the world grows: contraception in the 21st century

Aitken¹,

Baker²,

Doncel³

et al. 2008

J. Clin. Invest.

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Contraceptives that are readily available and acceptable are required in many poorer countries to reduce population growth and in all countries to prevent maternal morbidity and mortality arising from unintended pregnancies. Most available methods use hormonal steroids or are variations of barrier methods. Reports from several fora over the last 12 years have emphasized the number of unwanted pregnancies and resultant abortions, which indicate an unmet need for safe, acceptable, and inexpensive contraceptive methods. This unmet need can be assuaged, in part, by development of new nonhormonal contraceptive methods. This Review addresses the contribution that the "omic" revolution can make to the identification of novel contraceptive targets, as well as the progress that has been made for different target molecules under development.

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“…The addition of small doses of a prostaglandin analogue (such as misoprostol) has a synergistic effect resulting in nearly 100% complete abortion [18,19] with lower doses than those required when the prostaglandin analogue is used alone. Moreover, the addition of mifepristone to misoprostol increases complete abortion at a faster rate up to 63 days gestation [16].…”

Section: Introductionmentioning

confidence: 99%