2020
DOI: 10.1088/1742-6596/1655/1/012034
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Terpenoid as Antibacterial Produced by Endophyte Fusarium oxysporum LBKURCC41 from Dahlia variabilis Tuber

Abstract: Fusarium oxysporum LBKURCC41 is an endophytic isolated from Dahlia variabilis tubers from Padang Luar, West Sumatra. The strain was fermented using modified Huangs’ media, ie using corn as a carbon source for 15 days. The purpose of this study is to isolate secondary metabolites from LBKURCC41 strains. The filtrate from the liquid fermentation media was extracted using EtOAc:MeOH at a ratio of 95:5 to 50:50. Purification using fast chromatography was performed with a mixture of BAW (5:1:4). The structure was e… Show more

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Cited by 3 publications
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“…The sesquiterpenoid, 137 isolated from F. oxysporum LBKURCC41 obtained from Dahlia variabilis tubers showed antibacterial activity towards S. aureus and E. coli (IZD 2.1 mm) in the agar disc diffusion assay [103]. Cosmosporasides F-H (138-140), new sugar alcohol conjugated acyclic sesquiterpenes isolated from F. oxysporum SC0002, showed weak cytotoxic effect towards A549, HepG2, and HeLa (inhibition rates 13-24%) (Figure 15).…”
Section: Terpenoidsmentioning
confidence: 99%
“…The sesquiterpenoid, 137 isolated from F. oxysporum LBKURCC41 obtained from Dahlia variabilis tubers showed antibacterial activity towards S. aureus and E. coli (IZD 2.1 mm) in the agar disc diffusion assay [103]. Cosmosporasides F-H (138-140), new sugar alcohol conjugated acyclic sesquiterpenes isolated from F. oxysporum SC0002, showed weak cytotoxic effect towards A549, HepG2, and HeLa (inhibition rates 13-24%) (Figure 15).…”
Section: Terpenoidsmentioning
confidence: 99%
“…É possível observar a ação antibacteriana contra cepas de S. aureus, E. coli e Bacillus sp., relatadas como bactérias causadoras de graves infeções em humanos (Piska et al, 2020). Em seguida, as Figuras 2 a 10 apresentam as estruturas químicas e os dados analíticos de cada composto listado.…”
Section: Metabólitos Com Potencial Antimicrobianos Isolados De Espéci...unclassified
“…Starratt et al [ 45 ] isolated three fungal compounds from F. oxysporum CM 192679 which were Ergosterol peroxide, Ergosterol and Cerevisterol; as Mohamed et al [ 46 ] identified other three different terpenoid compounds isolated from Egyptian strain of F. oxysporum called (22E,24R)-stigmasta-5,7,22-trien-3-β-ol, wortmannin and stigmasta-4,6,8 (14),22-tetraen-3-one. Complementary to above, fusariumin D and fusariumin C were extracted from Fusarium oxysporum ZZP-R1 [ 47 ] while other experiment [ 48 ] confirmed the existence of F. oxysporum SC0002 to cosmosporaside G, cosmosporaside F and cosmosporaside H. Kim et al [ 49 ] identified isoverrucarol as fungal terpenoid extracted from F. oxysporum CJS-12 strain while (1R,2S,3R)-3-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-1,2-dimethylcyclopentanol was detected from Korean isolate of F. oxysporum identified as LBKURCC41 [ 50 ]. The listed figure display structure of ginkgolide B terpenoid obtained from F. oxysporum SYP0056 was isolated from Ginkgo biloba in China [ 51 ].…”
Section: Introductionmentioning
confidence: 99%