:
Owing to the growing demand of compelling antimicrobial agents, chalcones and their heterocyclic derivatives
have engrossed prodigious attention of medicinal chemists as effective clinical template for the synthesis of such agents on
account of their structural diversity and molecular flexibility. Chalcones are celebrated as fortunate scaffold in an area of
both synthetic as well as natural product chemistry. They are reflected as remarkable section of logically occurring pharmacophore that possess comprehensive scale of biological actions such as anticancer, antimalarial, anticancer, antiviral, antiinflammatory, etc. which in regard proposes them with high degree of assortment and noble therapeutic profile. They act as
a crucial intermediate for the synthesis of novel heterocyclic skeletons holding biodynamic behavior. This review emphasize
on different aspects of chalcones including their natural sources, recent synthetic methodologies and evaluation of their antimicrobial potential. It is expected as a persuasive compilation on chalcones that may benefit the experts to design potent
and less toxic chalcone referents as medicinal agents.