Terpenoids—LXX

Sesquiterpene lactones and other chemical constituents of Mikania hoehnei R.

“…The chromatographic fractionation of hexane, ethyl acetate and ethanol extracts yielded stigmasterol, β-sitosterol and campesterol, lupeyl acetate, 21 β-sitosteryl and stigmasteryl glucopyranosides, 22 Structure of the guaianolide 1 was deduced from the IR, MS, 13 C and 1 H NMR spectra data and the stereochemistry was defined from the coupling constants' value J and nOe difference correlations. This lactone has been previously reported as a synthetic compound obtained in the controlled acetylation of the natural guaianolide Integrifolin (8-epi-desacylcynaropicrin).…”

“…1 H NMR (300 MHz) and 13 14, No. 5, 2003 in the herbarium of the Department of Biology, FFCLRP/ USP and was used for the authentication of the species.…”

“…Their structures were proposed on the basis of spectroscopic data and comparisons of the attributed signals with previously reported data. [12][13][14][15][16][17] Although the occurrence of sesquiterpene lactones is common in species of Mikania, guaianolides have been found in only 3 of the 46 species studied so far, e.g. in M. vitifolia, 18 M. haenkeana 19 and M. mendocina.…”

Augmentation of the Pharmacological Action of Corydalis Tuber by Saussurea Root in Isolated Mouse Ileum

“…Sesquiterpenoids [7][8][9][10] are known as representative constituents of Saussurea root. It was previously reported that 1, one of these principal sesquiterpenes, exhibited a depression of carbachol-induced contraction in the colon of rats in vitro.…”

A Sesquiterpene, Dehydrocostus Lactone, Inhibits the Expression of Inducible Nitric Oxide Synthase and TNF-α in LPS-Activated Macrophages

“…This fraction was chromatographed on a silica gel (20 g) column eluted with CH 2 Cl 2acetone (100 : 1, 70 : 1 and 50 : 1, 100 ml each) gradients yielding an active compound (7 mg) at the elution volume of 230 ml. The structure of the active compound was determined by spectral analysis as dehydrocostus lactone (14).…”