Terpenoids with alpha-glucosidase inhibitory activity from the submerged culture of Inonotus obliquus

Ying, You‐Min; Zhang, Linyan; Zhang, Xia; Bai, Haibo; Liang, Dong-E; Ma, Lie‐Feng; Shan, Wei‐Guang; Zhan, Zha‐Jun

doi:10.1016/j.phytochem.2014.09.022

Cited by 71 publications

(25 citation statements)

References 30 publications

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“…Extract of I. obliquus tested in our study possessed inhibitory potential of both enzymes investigated (Table 1). A previous study by Ying et al (2014) revealed terpenoids from this species as inhibitors of glucosidase. In our previous study (Glamočlija et al, 2015) oxalic acid was the only organic acid detected in the extract of I. obliquus (72 mg/g extract).…”

Section: Mushroom Species Yield Of Extracts (%) α-Amylase Inhibition;mentioning

confidence: 67%

An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes

Stojković

Smiljković

Ćirić

et al. 2019

South African Journal of Botany

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As a continuation of our search for biologically active mushroom species the present study investigates in vitro antidiabetic properties of six edible and medicinal mushroom species: Agaricus blazei Murrill, Coprinus comatus (O.F.Müll.) Pers., Cordyceps militaris (L.) Fr., Inonotus obliquus (Ach. ex Pers.) Pilát, Morchella conica Pers. and Phellinus linteus Berk. & M.A. Curtis. In vitro assays on α-amylase and α-glucosidase enzyme inhibition were performed with methanolic extracts of the selected mushrooms. Furthermore, we calculated the necessary daily intake of mushroom extracts and dry mushroom powders based on the equivalent doses of therapeutic drug acarbose given to diabetic patients per day. Our comparative study on enzyme inhibition showed that the most promising potential is ascribed to I. obliquus extract, while no inhibition of α-amylase was recorded with M. conica and C. militaris methanolic extract at the tested concentration. This comparative study is the first highlighting in vitro antidiabetic potential by inhibition of α-amylase and α-glucosidase with methanolic extracts; which makes the investigated species more promising for the diabetes type-2 treatment by an additional and different mechanism of action.

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Section: Mushroom Species Yield Of Extracts (%) α-Amylase Inhibition;mentioning

confidence: 67%

An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes

Stojković

Smiljković

Ćirić

et al. 2019

South African Journal of Botany

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“…Non-glycosylated pentacyclic triterpenoids such as ursolic acid (3b-hydroxyurs-12-en-28-ic acid), corosolic acid (2a, 3b-dihydroxyurs-12-en-28-ic acid) and oleanolic acid (3b-hydroxyolean-12-en-28-ic acid) are lipophilic constituents, which have recently aroused great interest in the context of phytotherapy because of their comprehensive biological properties, including anti-inflammatory, anti-ulcer, antioxidant, hepatoprotective, anticancer, antiatherosclerotic and antidiabetic ones [ 61 , 62 , 63 , 64 , 65 , 66 ].…”

Section: Phytocompounds Content In P Padus Andmentioning

confidence: 99%

Phytopharmacological Possibilities of Bird Cherry Prunus padus L. and Prunus serotina L. Species and Their Bioactive Phytochemicals

2020

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Wild cherry is a plant observed in the form of trees or shrubs. This species comprises about twenty kinds of plants and the most popular are two, Prunus padus L. and Prunus serotina L., whose properties and content of phytochemical compounds are subject to studies. Wild cherry contains many active compounds, including tocopherols, vitamins, polyphenols and terpenes, which can have beneficial effects on health. On the other hand, wild cherry contains cyanogenic glycosides. Nevertheless, current research results indicate pro-health properties associated with both P. serotina and P. padus. The aim of this study was to collect and present the current state of knowledge about wild cherry and to review available in vitro and in vivo studies concerning its antioxidant, anti-inflammatory, antibacterial and antidiabetic activity. Moreover, the current work presents and characterizes phytochemical content in the leaves, bark and fruits of P. padus and P. serotina and compiles data that indicate their health-promoting and functional properties and possibilities of using them to improve health. We find that the anatomical parts of P. padus and P. serotina can be a valuable raw material used in the food, pharmaceutical and cosmetic industries as a source of bioactive compounds with multi-directional action.

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“…It is an edible mushroom, and also a traditional remedy used for curing various diseases since the 12th century, such as cerebrovascular diseases, diabetes, and gastrointestinal diseases [ 2 ]. Modernly, it was verified that it was effective against hyperglycemia [ 3 ], cancer [ 4 ], inflammation [ 5 ], and especially regulation of metabolism [ 1 ]. Bioactives, such as triterpenes, polysaccharides, polyphenols, and melanin, have been isolated and characterized in I. obliquus , and are responsible for antitumor activities [ 6 , 7 , 8 ], anti-inflammatory ability [ 5 ], antioxidant effects [ 9 ], hypoglycemic ability [ 3 ], immunomodulatory activity [ 10 ], and antimutagenic properties [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Actions of Inonotus obliquus against Hyperuricemia through XOD and Bioactives Screened by Molecular Modeling

Yong

Chen

Liang

et al. 2018

IJMS

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Inonotus obliquus is an edible mushroom and also a remedy against various diseases, especially metabolic syndrome. In this paper we report the actions of an ethanol extract of I. obliquus (IOE) against hyperuricemia in hyperuricemic mice, and the screen of bioactives. The extract (IOE) was prepared by extracting I. obliquus at 65 °C with ethanol, and characterized by HPLC. IOE at low, middle, and high doses reduced serum uric acid (SUA) of hyperuricemic mice (353 μmol/L) to 215, 174, and 152 μmol/L (p < 0.01), respectively, showing similar hypouricemic effectiveness to the positive controls. IOE showed a non-toxic impact on kidney and liver functions. Of note, IOE suppressed xanthine oxidase (XOD) activity in serum and liver, and also down-regulated renal uric acid transporter 1 (URAT1). Four compounds hit highly against XOD in molecular docking. Overall, the four compounds all occupied the active tunnel, which may inhibit the substrate from entering. The IC50 of betulin was assayed at 121.10 ± 4.57 μM, which was near to that of allopurinol (148.10 ± 5.27 μM). Betulin may be one of the anti-hyperuricemia bioactives in I. obliquus.

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Terpenoids with alpha-glucosidase inhibitory activity from the submerged culture of Inonotus obliquus

Cited by 71 publications

References 30 publications

An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes

An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes

Phytopharmacological Possibilities of Bird Cherry Prunus padus L. and Prunus serotina L. Species and Their Bioactive Phytochemicals

Actions of Inonotus obliquus against Hyperuricemia through XOD and Bioactives Screened by Molecular Modeling

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