Testicular Metastasis from Renal Cell Carcinoma: A Case Report and Review of the Literature

Abstract

Testicular metastases from renal cell carcinoma (RCC) are extremely rare. To the best of our knowledge, only 33 cases have been described in the literature. Most of the reported cases are of unilateral testicular metastasis from RCC. We report a case of metachronous ipsilateral testicular metastasis from RCC in a 78-year-old man 6 years after nephrectomy. Scrotal ultrasonography showed a 4 × 5 cm mass in the right testis. Right inguinal orchiectomy was performed for diagnosis. Computed tomography revealed liver and lung metastases. First-line therapy with sunitinib was started in November 2016 for metastatic RCC.

Metastatic Renal Cell Carcinoma to the Testis: A Clinicopathologic Analysis of Five Cases

“…Bandler et al described the first case of RCC metastatic to the testis in 1946 [17]. Since then, there have been 34 reported cases of testicular spread of RCC [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”

“…In this circumstance, it could be misdiagnosed as one of the many types of primary testicular tumors. Most reported examples of metastatic carcinoma in the testis have been individual case reports [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Metastatic renal cell carcinoma (RCC) involving the testis comprises a small portion of this group of cases.…”

Papillary renal cell carcinoma with testicular and penile metastases: A case report and literature review

“…Metastatic disease to the testes is uncommon, with an estimated incidence rate of 0.3%–3.6%. 2 Testicular metastasis from RCC is extremely rare; only 33 cases have been described in the literature. 2 The clinical presentations of these cases vary; however, the most common method of discovery was the incidental finding of metastatic RCC in the orchiectomy pathology.…”

“… 1 Testicular metastasis from RCC is extremely rare; only 33 cases have been described in the literature. 2 There was only 1 case whichever reported that sarcomatoid RCC with extension into the penis. There is currently no literature that describes the metastasis of pRCC to both testis and penis, which is why this case is exceptionally unique and worthy of documentation.…”

Synchronous mixed germ cell tumor of testis and renal cell carcinoma: A rare presentation

“…Historically, renal cell carcinoma was diagnosed only at an advanced stage because of its location within the retroperitoneum. Despite this increase in asymptomatic diagnoses, 30% of patients present with metastatic disease [6].…”