Testicular Toxicity and Sperm Quality Following Exposure to Solignum: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats

Patrick-Iwuanyanwu, Kingsley C.; Udowelle, Nnaemeka Arinze; Okereke, Chioma

doi:10.5455/jihp.20151125081952

Cited by 4 publications

(5 citation statements)

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“…The cauda epididymis was gently minced and assayed for sperm count, sperm motility and sperm morphology. The relative testicular weights were calculated using the following formula:

Organ weight / Final body weight \times 100

(El‐Aziz, El‐Fark, & Hamdy, ; Patrick‐Iwuanyanwu, Udowelle, & Okereke, )…”

Section: Methodsmentioning

confidence: 99%

Testicular microanatomical and hormonal alterations following use of antiretroviral therapy inSprague Dawleyrats: Role of Naringenin

et al. 2018

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Human immunodeficiency virus-infected man may require assisted reproductive technology not just for safer conception but also due to subfertility. The study investigated the effect of antiretroviral drugs on the fertility potentials of males and the possible protective role of Naringenin, using Sprague Dawley rats. Thirty adult male Sprague Dawley rats were grouped into-A: Distilled water; B: Highly Active Antiretroviral Therapy (HAART); C: Naringenin 40 mg/kg; D: Naringenin 80 mg/kg, E: HAART + Naringenin 40 mg/kg; F: HAART + Naringenin 80 mg/kg. The rats were euthanised after 10 weeks. Results showed a significant decrease in sperm count in group B when compared to the control and other groups. Spermatozoa with normal morphology also reduced significantly in the B group and progressive sperm motility reduced when compared to the control, D and the F group. The serum testosterone was not significantly different between groups A and B, however the groups C and D displayed significant increase when compared to groups A and B. The serum luteinising hormone was significantly higher in group B when compared to groups A, E and F. Our data suggest that Naringenin improves the male reproductive anatomy and function, therefore, it promises to be a beneficial adjuvant for mitigating HAART testicular and reproductive perturbations.

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“…The cauda epididymis was gently minced and assayed for sperm count, sperm motility and sperm morphology. The relative testicular weights were calculated using the following formula:

Organ weight / Final body weight \times 100

(El‐Aziz, El‐Fark, & Hamdy, ; Patrick‐Iwuanyanwu, Udowelle, & Okereke, )…”

Section: Methodsmentioning

confidence: 99%

Testicular microanatomical and hormonal alterations following use of antiretroviral therapy inSprague Dawleyrats: Role of Naringenin

et al. 2018

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“…To perform the histomorphometric examination, approximately seven sections on a vertical axis starting from the polar to the equator were studied using unbiased stereological techniques to measure the seminiferous tubular area and height [ 37 ].…”

Section: Methodsmentioning

confidence: 99%

“…The vertical diameter of the seminiferous tubule was denoted as d1, and the horizontal diameter was indicated as d2 while the mean diameter indicated as (D) was documented as an observation. This was employed to reduce the longitudinal profiles that showed different degrees of irregular shrinkage or damage [ 37 ]. The diameter and height of the seminiferous tubular epithelium were scanned using Leica SCN 400 (Leica Microsystems GmbH, Wetzlar, Germany) and measured using the image analyzer and Leica microsystem software, while cell counts were done through image J software.…”

Section: Methodsmentioning

confidence: 99%

Histomorphometric changes in testis following administration of tenofovir nanoparticles in an animal model

Naidu,

Olojede,

Lawal

et al. 2024

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Background Nanoparticle-based drugs are new inventions in the management of the Human immunodeficiency virus (HIV) pandemic, especially resistant forms of the virus in anatomical sanctuary sites and organs such as the testis. However, safety issues must be resolved to attain the optimal potential of newer nano-drug formulations. Aim The study investigated the toxicological potential of synthesized Tenofovir Nanoparticles (TDF-N) on testicular indices when used for the prevention and treatment of HIV. Methodology Fifteen male Sprague–Dawley (SD) rats with weight ranging from 230 g to 250 g were randomly assigned into groups A (control, saline), B (TDF), and C (TDF-N). The testes were removed for sperm analysis and processed for H/E and PAS stains. Cell counts and cellular measurements; the diameter and the area of the testicular seminiferous tubules were measured using ImageJ and Leica software 2.0. Results A significant reduction (p < 0.05) in sperm count was noticed in the TDF-N group. Also observed in the TDF and TDF-N groups was a significant reduction (p < 0.05) in sperm motility and in the number of dead sperms compared with the control. Sperm abnormalities such as distorted basement membranes, loss of germ cells, hypocellular interstitium, and loss of spermatogenic series were increased in the TDF and TDF-N groups. There was also a significant reduction (p < 0.05) in the cell count, diameter, and area of seminiferous tubules observed in these groups. Conclusion TDF and TDF-N may be detrimental to the testis and testicular tissue, leading to significantly reduced sperm counts, motility, and ultimately–male fertility.

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“…Our findings of IM are in agreement with others findings using different pesticides in rodents, viz. bromopropane and dimethoate an organophosphorus compound (50) , ndosulfan, malathion (18) , methomyl an insecticide compounds (42) , cypermethrin (6,7) and Solignum a Permethrin (53) .…”

Section: Spermatogenesismentioning

confidence: 99%

Effect of Imidacloprid on the Testicular Activity and Endocrine Disruptive and Its Impact on Fertility in Male Rats

Mohammed S. A. Al-Awar

2021

Indian Journal of Forensic Medicine & Toxicology

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The present study aims at finding out effect of imidacloprid (IM) on the testicular activity and endocrine disruptive and its impact on fertility in male rats. Results. Administration of imidacloprid, orally (2 doses:45 and 90 mg/kg b.w) to adult male rats for 4(D1), 8 (D2) or 12 (D3) weeks caused a disorganization of the spermatogenic cells, degeneration and congested of interstitial connective tissue, degeneration of seminiferous tubule, reduction in number of cell layers per seminiferous tubules, number of seminiferous tubule sections, percentage of normal seminiferous tubules, seminiferous tubule diameter height of the germinal epithelium, Infiltration of the immune-mononuclear cells, and a decrease in weight of the body, testes, epididymis, Vas deference, Seminal vesicle and prostate, this change was significant after 4 weeks of treatment in high dose treated rats whereas it was significant after 8 weeks treatment in low dose treated rats, when compared to controls. Fertility index in female, Gestation index, weight of the litter born and number pups to rats mated with IM treated (two doses) males in D2 or D3 was lower than controls whereas Gestation period, Fertility index of mal, viability index, Sex-ratio at birth did not significantly vary from controls.

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Testicular Toxicity and Sperm Quality Following Exposure to Solignum: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats

Cited by 4 publications

References 0 publications

Testicular microanatomical and hormonal alterations following use of antiretroviral therapy inSprague Dawleyrats: Role of Naringenin

Testicular microanatomical and hormonal alterations following use of antiretroviral therapy inSprague Dawleyrats: Role of Naringenin

Histomorphometric changes in testis following administration of tenofovir nanoparticles in an animal model

Effect of Imidacloprid on the Testicular Activity and Endocrine Disruptive and Its Impact on Fertility in Male Rats

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