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Cannabis sativa have been suggested to disrupt the normal ovulatory cycle and hormonal secretion in animals. In this study, we investigated the changes in progesterone and estrogen levels in female Wistar rats as a result of oral administration of ethanolic extract of C. sativa for 7, 14 and 21 days consecutively. A total of 18 female rats were used and selectively divided into three groups (A, B and C) based on their body weight. Group A was control group while Group B and C were test groups and were given 200 ml and 400 ml/kg body weight of the extract respectively. At the end of each week, blood sample was collected from the various groups and subjected to estrogen and progesterone hormonal assay. The estrogen levels observed in Groups B and C were 6.33 ± 5.30 and 2.23 ± 1.07 respectively after 21 days. At the end of the experiment, a significant reduction in progesterone and estrogen levels was observed in the test groups. The present findings demonstrate that medium term (21 days) treatment of female rat with ethanolic extract of Cannabis sativa results to a significant decrease in progesterone and estrogen levels thereby leading to female sexual dysfunction directly or indirectly.

The adverse health effects associated with heavy metal pollution have become a subject of topical discussion. Using standard methods, this study evaluated the accumulation and toxicological risks of heavy metal deposition on top soils of school playgrounds in ObioAkpor LGA. Results obtained from the top soils, sampled from 10 different schools showed that the concentration of heavy metals assessed, followed the trend; HgHg>Cu>Cd>As while the highest (0.0213) and least (0.0162) total hazard index value occurred at RBPS and MOM respectively. These values obtained for this study indicate that the school playground's soils are still within the recommended heavy metal content safe levels.