Testicular tumors as a possible cause of antisperm autoimmune response

Paoli, Donatella; Gilio, Barbara; Piroli, Emanuela; Gallo, Mariagrazia; Lombardo, Francesco; Dondero, F.; Lenzi, Andrea; Gandini, L.

doi:10.1016/j.fertnstert.2007.11.084

Cited by 22 publications

(12 citation statements)

References 32 publications

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“…Approximately 10% of men being evaluated for infertility have antisperm antibodies (ASAs). 22 Studies have shown various correlations between testicular cancer and ASAs ( Table 1). The effect of ASA on spermatogenesis is not clear both in the infertile population or patients with testicular cancer.…”

Section: Autoimmune Effects Of Testicular Cancermentioning

confidence: 99%

Infertility with Testicular Cancer

Ostrowski¹,

Walsh²

2015

Urologic Clinics of North America

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Section: Autoimmune Effects Of Testicular Cancermentioning

confidence: 99%

Infertility with Testicular Cancer

Ostrowski¹,

Walsh²

2015

Urologic Clinics of North America

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“…In fact, this point of view is getting obsolete because the "barrier" currently is regarded not as an anatomical obstacle for antibodies, but informational barrier established by local paracrine/juxtacrine action of anti-inflammatory cytokines produced in testis and down-regulation of autoimmunity by androgens [54]. Anyway, local inflammation breaks relative immunological tolerance, which event may have serious consequences for the reproductive system [2,7,10,11,22,25,41,46,[55][56][57][58][59][60].…”

Section: Sperm Antigens and Antisperm Antibodies (Asas): Past And Presentmentioning

confidence: 99%

“…Hence, male infertility is a multifactorial syndrome that includes a wide range of disorders, affecting not only the reproductive system, but also the immunoneuroendocrine apparatus [10,14,15]. The most common causes of male infertility are genitourinary malformations, genetic disorders (particularly, cystic fibrosis and chromosome aberrations), congenital diseases of the male reproductive system (cryptorchidism, monorchism, phimosis, and hypospadias), varicocele, neuroendocrine disorders and chronic stress, traumas and inflam-matory diseases of the reproductive tract, both with infectious and non-infectious etiology, lifestyle factors (alcohol, tobacco smoking, drug addiction), and testicular tumors [5,11,[14][15][16][17][18][19][20][21][22][23][24][25]. Immunopathological factors are leading in pathogenesis of male infertility, essential for its cases regardless of different etiology.…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine and Endocrine Deregulation

Черешнев¹,

Pichugova²,

Beikin³

et al. 2021

Preprint

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According to global data, there is a male reproductive potential decrease. Pathogenesis of male infertility often is associated with autoimmunity towards sperm antigens essential for fertilization. Antisperm autoantibodies (ASAs) have immobilizing and cytotoxic properties, impairing spermatogenesis, causing sperm agglutination, altering spermatozoa motility and acrosomal reaction, thus preventing ovum fertilization. Infertility diagnosis requires mandatory check for the ASAs. The concept of blood-testis barrier currently is re-formulated with emphasis of informational paracrine and juxtacrine effects, rather than simple anatomical separation. Aetiology of male infertility includes both autoimmune and non-autoimmune diseases, but equally develops through autoimmune links of pathogenesis. Varicocele commonly leads to infertility due to testicular ischemic damage, venous stasis, local hyperthermia, and hypoandrogenism. However, varicocelectomy can alter blood-testis barrier facilitating ASAs production as well. There are contradictory data on the role of ASAs in pathogenesis of varicocele-related infertility. Infection and inflammation both promote ASAs production due to “danger concept” mechanisms and because of antigen mimicry. Systemic pro-autoimmune influences like hyperprolactinemia, hypoandrogenism and hypothyroidism also facilitate ASAs production. Diagnostic value of various ASAs was not yet clearly attributed, and their cut-levels not agreed neither in sera nor in ejaculate. The assessment of the autoimmunity role in pathogenesis of male infertility is ambiguous.

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“…Rat models have demonstrated that altered homeostasis of pro-inflammatory cytokines such as IL-6, IL-8, and TNF-α impair the blood-testis barrier, thereby exposing spermatozoa to elevated levels of reactive oxygen species (ROS) that can cause germ cell apoptosis and sloughing (17)(18)(19)(20). Anti-sperm antibodies, found predominantly in testicular cancer, may further impair spermatogenesis, though the evidence is equivocal (21,22).…”

Section: Effects Of Cancer On Fertilitymentioning

confidence: 99%

Oncofertility in adult and pediatric populations: options and barriers

Halpern¹,

Das²,

Faw³

et al. 2020

Transl Androl Urol

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Cancer and its treatments can affect fertility in a variety of ways, and recent advances in cancer detection and treatment have led to an increasing number of cancer survivors for whom future fertility is a primary concern. Oncofertility is the study of interactions between cancer, anti-cancer therapy, fertility, and reproductive health. Fertility preservation aims to optimize fertility potential before initiation of gonadotoxic therapies. Sperm cryopreservation from an ejaculated sample is the gold standard for adults and post-pubertal adolescents, though added maneuvers such as medical therapy, penile vibratory stimulation, and electroejaculation can be employed when appropriate. When all these approaches fail, testicular sperm extraction can be used to obtain and cryopreserve testicular sperm from the azoospermic patient. Fertility preservation in the pre-pubertal pediatric patient is still experimental, but recent scientific breakthroughs with use of spermatogonial stem cells and testicular tissue transplantation offer great promise for the future.While there may be several practical, cultural, religious, and other barriers to fertility preservation, the establishment of a dedicated fertility preservation team can help to overcome these obstacles and optimize the utilization of fertility preservation in cancer patients of all ages.

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Testicular tumors as a possible cause of antisperm autoimmune response

Cited by 22 publications

References 32 publications

Infertility with Testicular Cancer

Infertility with Testicular Cancer

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine and Endocrine Deregulation

Oncofertility in adult and pediatric populations: options and barriers

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