Testosterone replacement increases vasodilatory reserve in androgen-deficient female rats

Cooper, Brian C.; Gokina, Natalia I.; Osol, George

doi:10.1016/j.fertnstert.2006.06.033

Cited by 8 publications

(6 citation statements)

References 23 publications

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“…High-dose exogenous testosterone in primate models was associated with a doubling of atherosclerosis [62] and similar results of increases in atherosclerotic plaques were observed in rabbit models [65]. Of note, physiological administration of testosterone to androgen-deficient rats led to an improvement in the vasodilator response of the endothelium [66].…”

Section: Exogenous Testosteronesupporting

confidence: 56%

The Safety of Postmenopausal Testosterone Therapy

Maclaran

Panay

2012

Womens Health (Lond Engl)

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Testosterone is increasingly used as part of postmenopausal HRT regimens. Unfortunately, few androgenic preparations designed specifically for use in women have been approved by regulatory authorities. Ongoing concerns exist surrounding the potential long-term effects of testosterone therapy. Here, we review the most recent data on postmenopausal testosterone therapy, focusing particularly on the effects of testosterone on breast, endometrium and cardiovascular health.

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Section: Exogenous Testosteronesupporting

confidence: 56%

The Safety of Postmenopausal Testosterone Therapy

Maclaran

Panay

2012

Womens Health (Lond Engl)

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“…Male animals were treated with oral estradiol valerate (E2V, 0.05 mg/kg/day), different doses of subcutaneous T (T 1 mg/kg/day and 5 mg/kg/day) or subcutaneous DHT (DHT 0.1 mg/kg/day, 1 mg/kg/day, 5 mg/kg/day), or placebo. These doses are largely in the range of those currently used in literature to investigate the effect of T and DHT therapy in gonadectomizated adult rats in different target tissues, such as the brain, the cardiovascular system, and the breast [25–28]. Male animals have physiologically higher level of T, and therefore the doses of T chosen for this study design were higher in male rats.…”

Section: Methods and Main Outcome Measurementioning

confidence: 99%

Sexually Dimorphic Effects of Testosterone Administration on Brain Allopregnanolone in Gonadectomized Rats

Pluchino

Ninni

Casarosa

et al. 2008

The Journal of Sexual Medicine

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Introduction Clinical and biological evidences have shown a wide range of neuroactive effects of testosterone administration. Aim Evaluation of the effects of 2-weeks treatment with testosterone (T), Dihydrotestosterone (DHT), and estradiol valerate (E2V) on brain and serum allopregnanolone (AP) in gonadectomized rats of both sexes. Main Outcome Measures AP levels were measured in frontal and parietal lobe, hippocampus, hypothalamus, anterior pituitary, and in serum. Methods Eight groups of Wistar female and eight groups of Wistar male rats were included. For each sex, one group of fertile and one group of gonadectomized rats were employed as control receiving placebo. The others groups received subcutaneous T at the dose of 10 µg/kg/day and 100 µg/kg/day for female rats, and 1 mg/kg/day and 5 mg/kg/day for male rats, or DHT at the doses of 1 µg/kg/day, 10 µg/kg/day, and 100 µg/kg/day for females, and 0, 1 µg/kg/day, 1 mg/kg/day and 5 mg/kg/day for males, or E2V (0.05 mg/Kg/day). Results: Ovariectomy (OVX) and orchidectomy (OCX) induced a significant decrease in AP in all brain areas analyzed, as well as in serum. In OVX rats, T replacement, as well as E2V, significantly increased AP content in all brain areas and in plasma. In OCX, T and E2V did not actively result in influencing AP concentration in frontal and parietal lobe, while it produced a significant rise in AP levels in the hippocampus, hypothalamus, anterior pituitary, and serum. Conversely, DHT replacement had no affect on AP levels anywhere or at any administered dose, either in males or in female rats. Conclusion Gender difference and T therapy affect brain AP synthesis/release during the reproductive aging. This effect becomes particularly evident in the brain of ovariectomized animals, where the content of this specific neurosteroid is much more responsive than male animals to testosterone replacement.

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“…115 In addition, administration of physiological testosterone levels to androgen-deficient female rats improves the vasodilatory reserve of the vascular endothelium. 116 …”

Section: Atherosclerosismentioning

confidence: 99%

Testosterone, SHBG and cardiovascular health in postmenopausal women

Brand

Schouw

2010

Int J Impot Res

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Cardiovascular disease (CVD) affects men and women differently with women having a lower incidence and later onset of disease. Research has recently refocused interest on the cardiovascular role of androgens. The purpose of this review is to summarize the evidence available on the association between testosterone and cardiovascular health in postmenopausal women. Published studies relating testosterone and sex hormone-binding globulin (SHBG) to CVD and its risk factors were reviewed. Studies included in this review suggest that increased androgenicity, characterized by high testosterone and low SHBG levels, is associated with an adverse CVD risk factor profile in postmenopausal women. However, evidence for an association with cardiovascular events is lacking and it is uncertain whether the observed associations with endogenous testosterone have clinical implications regarding the use of postmenopausal testosterone therapy. Large-scale, longitudinal studies relating testosterone and SHBG levels to cardiovascular risk factors and endpoints are needed to determine the temporal relationship between androgenicity and cardiovascular risk and to ascertain the long-term efficacy and safety of testosterone therapy in postmenopausal women.

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Testosterone replacement increases vasodilatory reserve in androgen-deficient female rats

Cited by 8 publications

References 23 publications

The Safety of Postmenopausal Testosterone Therapy

The Safety of Postmenopausal Testosterone Therapy

Sexually Dimorphic Effects of Testosterone Administration on Brain Allopregnanolone in Gonadectomized Rats

Testosterone, SHBG and cardiovascular health in postmenopausal women

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