Tetracyclines inhibit tissue collagenase activity

A Non-antibacterial Chemically-modified Tetracycline Inhibits Mammalian Collagenase Activity

“…The evidence includes the following facts: (i) These drugs inhibit collagenase activity and collagen breakdown in germ-free as well as conventional rats Golub et al, 1985b); (ii) their administration in vivo inhibits collagenase activity and/or collagen destruction in non-infected tissues of humans (Perry and Golub, 1985;Greenwald et al, 1986), as well as in experimental animals Golub et al, 1985b;Seedor et al, 1985); (iii) these drugs directly inhibit mammalian collagenolytic activity in vitro Golub et al, 1984;Gomes et al, 1984;Golub et al, 1985a,b;Zucker et al, 1985); and (iv) their administration to humans in low doses substantially reduces the collagenase activity in the fluid of the periodontal pocket without producing a detectable effect on the subgingival microflora (Golub et al, 1985a;Golub et al, 1987). The present study provides direct evidence that the antibiotic and anti-collagenase properties of tetracycline reside in different parts of the molecule, since chemically modifying the drug to eliminate its anti-bacterial efficacy (Mitscher, 1978; did not reduce its anti-collagenase activity.…”

Use of Membranes Containing 20% Chlorhexidine and 40% Doxycycline for Treatment of Chronic Periodontal Pockets.

“…The decrease in the percentages of motiles and the increase in the percentages of cocci were highly significant in the treatment groups compared with the control group. Fig.2 Rate of release ( ƒÊg/h) of DOXY and CHx from HPMC membranes Table 1 Summary of the statistical differences between all the groups at each visit for the measurement parameters determined by analysis of variance Table 2 Mean and standard deviation of pocket depth in the treatment and control groups at the baseline (Visit 0) and for each visit up to 10 w (Visit 4) Table 3 Mean and standard deviation of gingival shrinkage for the treatment and control groups at the baseline (Visit 0) and at each visit up to 10 w (Visit 4) Table 4 Mean and standard deviation of the bleeding score for the treatment and control groups at the baseline (Visit 0) and at each visit up to 10 w (Visit 4) Table 5 Mean and standard deviation of crevicular fluid flow in the treatment and control groups at the baseline (Visit 0) and at each visit up to 10 w (Visit 4) Table 6 Mean and standard deviation of the percentage of curved and motile rods and spirochaetes in the treatment and control groups at the baseline (Visit 0) and at each visit up to 10 w (Visit 4) [24][25][26] and concentration in crevicular fluidi [11] , but also their fibroblast-stimulating activity [27,28] , enhancement of bone regeneration [29][30][31] , substantivity to mineralized tissues [32], and anticollagenolytic activity [33,34].…”

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“…Most widely used local drug delivery system in periodontal literature is Tetracycline as reported by Goodson. 14 Tetracycline inhibits collagenase activity, collagen degradation and bone resorption as reported by Golub et al 15 They exert their antimicrobial effect by inhibiting microbial protein synthesis. In the present study the results showed statistically significant reduction in pocket probing depth (PPD) from baseline to 6 months in both the Test and the Control groups.…”