Textbook outcome, chemotherapy compliance, and prognosis after radical gastrectomy for gastric cancer: A large sample analysis

Chen, Junyu; Lin, Guang-Tan; Chen, Qi‐Yue; Zhong, Qing; Liu, Zhiyu; Que, Si-Jin; Wang, Jia-Bin; Ji, Lin; Lü, Jun; Cao, Long‐Long; Ma, Lin; Tu, Ru‐Hong; Huang, Ze-Ning; Lin, Ju‐Li; Zheng, Hua-Long; Xie, Jian‐Wei; Li, Ping; Huang, Chang‐Ming; Zheng, Chao-Hui

doi:10.1016/j.ejso.2022.05.025

Cited by 15 publications

(9 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study revealed that older age (>75 years), advanced tumors (pT3/4), and high ASA (3/4) scores had a negative impact on TO and TOO. Despite diverse racial components and different recommendations for managing locally advanced GC, a similar conclusion was drawn in the study from the East, as mentioned 17 …”

Section: Discussionsupporting

confidence: 74%

“…Despite diverse racial components and different recommendations for managing locally advanced GC, a similar conclusion was drawn in the study from the East, as mentioned. 17 Appropriate LN dissection and POC were vital steps in improving TO and the dismal prognosis of patients with GC. It might be due to the fact that adequate lymphadenectomy performed in experienced centers might condition proper staging and AV administration.…”

Section: Discussionmentioning

confidence: 99%

“…16 Meanwhile, a large Asian study using the original 10 features' definition showed an even higher TO rate (84.2%). 17 Apart from clinical aspects, such TO discrepancies may result from the character of the analyzed registries (single institution, national, and high-volume expert centers). In the present study, 18 In the United States, a relatively low rate of AC reflects low TOO.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Textbook Oncological Outcome in European Gastrodata

et al. 2023

View full text Add to dashboard Cite

Objective: To assess the rate of textbook outcome (TO) and textbook oncological outcome (TOO) in European population based on Gastrodata registry. Background: TO is a composite parameter assessing surgical quality and strongly correlates with improved overall survival. Following the standard of treatment for locally advanced gastric cancer (GC), TOO was proposed as a quality and optimal multimodal treatment parameter. Methods: TO was achieved when all the following criteria were met: no intraoperative complications, radical resection according to the surgeon, pR0 resection, retrieval of at least 15 lymph nodes, no severe postoperative complications, no reintervention, no admission to the intensive care unit, no prolonged length of stay, no postoperative mortality and no hospital readmission. TOO was defined as TO with addition of perioperative chemotherapy compliance. Results: From the 2558 patients, 1700 were included in the analysis. TO was achieved in 1164 (68.5%) patients. The use of neoadjuvant chemotherapy (OR=1.33, 95%CI: 1.04-1.70) and D2 or D2+ lymphadenectomy (OR=1.55, 95%CI: 1.15-2.10) had a positive impact on TO achievement. Older age (OR=0.73, 95%CI: 0.54-0.94), pT3/4 (OR=0.79, 95%CI: 0.63-0.99), ASA 3/4 (OR=0.68, 95%CI: 0.54-0.86) and total gastrectomy (OR=0.56, 95%CI: 0.45-0.70), had negative impact on TO achievement. TOO was achieved in 388 (22.8%) patients. Older age (OR=0.37, 95%CI: 0.27-0.53), pT3-pT4 (OR=0.52, 95%CI: 0.39-0.69) and ASA 3-4 (OR=0.58, 95%CI: 95%CI: 0.43-0.79) had negative impact on TOO achievement. Conclusion: Despite successively improved surgical outcomes, stage‐appropriate chemotherapy in adherence to the current guidelines for multimodal treatment of GC remains poor. Further implementation of oncologic quality metrics should include greater emphasis on perioperative chemotherapy and adequate lymphadenectomy.

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Textbook Oncological Outcome in European Gastrodata

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Therefore, TO in GBC can be used to evaluate the surgery and perioperative care quality and to predict the long-term prognosis of patients after radical resection, similar to its use in hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and gastric cancer. [10,26] According to the 8th edition AJCC staging system, a minimum of six lymph nodes should be evaluated to adequately assess lymph node status intraoperatively. [27] In our study, the lymph nodes dissected ≥6 did not improve the long-term prognosis of GBC patients.…”

Section: Discussionmentioning

confidence: 99%

Textbook outcome in gallbladder carcinoma after curative-intent resection: a 10-year retrospective single-center study

Liu

Gao

et al. 2023

Chinese Medical Journal

View full text Add to dashboard Cite

Background: Textbook outcome (TO) can guide decision-making among patients and clinicians during preoperative patient selection and postoperative quality improvement. We explored the factors associated with achieving a TO for gallbladder carcinoma (GBC) after curative-intent resection and analyzed the effect of adjuvant chemotherapy (ACT) on TO and non-TO patients. Methods: A total of 540 patients who underwent curative-intent resection for GBC at the Department of Hepatobiliary Surgery of the First Affiliated Hospital of Xi'an Jiaotong University from January 2011 to December 2020 were retrospectively analyzed. Multivariable logistic regression was used to investigate the factors associated with TO. Results: Among 540 patients with GBC who underwent curative-intent resection, 223 patients (41.3%) achieved a TO. The incidence of TO ranged from 19.0% to 51.0% across the study period, with a slightly increasing trend over the study period. The multivariate analysis showed that non-TO was an independent risk factor for prognosis among GBC patients after resection (P = 0.003). Age ≤60 years (P = 0.016), total bilirubin (TBIL) level ≤34.1 μmol/L (P <0.001), well-differentiated tumor (P = 0.008), no liver involvement (P <0.001), and T1–2 stage disease (P = 0.006) were independently associated with achieving a TO for GBC after resection. Before and after propensity score matching (PSM), the overall survival outcomes of non-TO GBC patients who received ACT and those who did not were statistically significant; ACT improved the prognosis of patients in the non-TO group (P <0.05). Conclusion: Achieving a TO is associated with a better long-term prognosis among GBC patients after curative-intent resection, and ACT can improve the prognosis of those with non-TO.

show abstract

“…Among them, stomach adenocarcinoma (STAD) is the main pathological type of gastric cancer. Multiple clinical factors, such as age, tumor size, histological grade, lymphatic invasion, and number of lymph node metastases, have been shown in studies to affect the prognosis of gastric cancer [ 3 , 4 ]. Because of the complexity of gastric cancer incidence and tumor heterogeneity, despite the discovery of many prognostic markers, prediction efficiency remains insufficient [ 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

MAGEA11 as a STAD Prognostic Biomarker Associated with Immune Infiltration

et al. 2022

View full text Add to dashboard Cite

Expression of MAGE family member A11 (MAGEA11) is upregulated in different tumors. However, in gastric cancer, the prognostic significance of MAGEA11 and its relationship with immune infiltration remain largely unknown. The expression of MAGEA11 in pan-cancer and the receiver operating characteristic (ROC) and survival impact of gastric cancer were evaluated by The Cancer Genome Atlas (TCGA). Whether MAGEA11 was an independent risk factor was assessed by Cox analysis. Nomograms were constructed from MAGEA11 and clinical variables. Gene functional pathway enrichment was obtained based on MAGEA11 differential analysis. The relationship between MAGEA11 and immune infiltration was determined by the Tumor Immunity Estimation Resource (TIMER) and the Tumor Immune System Interaction Database (TISIDB). Finally, MAGEA11-sensitive drugs were predicted based on the CellMiner database. The results showed that the expression of MAGEA11 mRNA in gastric cancer tissues was significantly higher than that in normal tissues. The ROC curve indicated an AUC value of 0.667. Survival analysis showed that patients with high MAGEA11 had poor prognosis (HR = 1.43, p = 0.034). In correlation analysis, MAGEA11 mRNA expression was found to be associated with tumor purity and immune invasion. Finally, drug sensitivity analysis found that the expression of MAGEA11 was correlated with seven drugs. Our study found that upregulated MAGEA11 in gastric cancer was significantly associated with lower survival and invasion by immune infiltration. It is suggested that MAGEA11 may be a potential biomarker and immunotherapy target for gastric cancer.

show abstract

Textbook outcome, chemotherapy compliance, and prognosis after radical gastrectomy for gastric cancer: A large sample analysis

Cited by 15 publications

References 35 publications

Textbook Oncological Outcome in European Gastrodata

Textbook Oncological Outcome in European Gastrodata

Textbook outcome in gallbladder carcinoma after curative-intent resection: a 10-year retrospective single-center study

MAGEA11 as a STAD Prognostic Biomarker Associated with Immune Infiltration

Contact Info

Product

Resources

About