TGF-&lt;i&gt;β&lt;/i&gt;1 Stimulates Bone Resorption during Orthodontic Tooth Movement

Kikuta, Jun; Tsukada, Michiko; Takagi, Katsuma; Shimizu, Mariko; Hikida, Takuji; Nakayama, Erika; Kasai, Kazuhiko

doi:10.5466/ijoms.19.193

Cited by 1 publication

(2 citation statements)

References 20 publications

(9 reference statements)

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“…The substantially increased average TGF-β1 levels are consistent with additional administered caffeine doses. The findings are in line with the studies done by Kikuta et al 19 , which indicate that increasing TGF-β1 levels on the pressure side could be observed in the first 24 hours after applying optimal orthodontics strength. Applied mechanical orthodontics force to teeth triggers the macrophages-mediated inflammatory process, then, cytokines and growth factors are released.…”

Section: Discussionsupporting

confidence: 92%

“…The increased average TGF-β1 levels continued from day 1 to day 7. The study result regarding the involvement of TGF-β1 in bone remodeling in OTM using optimal orthodontic force (10 g), showing that TGF-β1 protein is expressed in the periodontal tissue on the pressure side on day 7, aligns with the results found by Kikuta et al 19 TGF-β1 produced by tooth movement stimulates bone resorption on the pressure side through osteoclastogenesis activation. TGF-β1 increases receptor activator of nuclear factor kappa B (RANK) level to stimulate osteoclasts differentiation.…”

Section: Discussionsupporting

confidence: 89%

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Increased TGF-β1 level after cocoa administration during orthodontics tooth movement in Cavia cobaya

Fikri,

Farmasyanti,

Pudyani

2024

Dent. J.

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Background: Orthodontic tooth movement (OTM) is a process of tooth movement in the alveolar socket through a bone remodeling process. Cocoa contains caffeine as a bioactive component. The number of studies on the effects of caffeine on orthodontic tooth movement is rising. Purpose: This study aimed to determine the effect of caffeine in cocoa administration on TGF-β1 levels in the pressure side during orthodontic tooth movement. Methods: Twelve Cavia cobaya were divided into 4 groups: control group (ONC), treatment group with 2.3 mg caffeine in cocoa (OWC1), 3.45 mg dose (OWC2) and 4.6 mg dose (OWC3) (n=3). A NiTi open coil spring with light force was applied to two lower incisors tooth of Cavia cobaya. TGF-β1 level in GCF of the pressure side was analyzed using ELISA on days 0, 1, 7, and 14. Data were analyzed using the Two-way ANOVA test (p<0.05) and the LSD Post-Hoc test. Results: Research indicated improvement of TGF-β1 level from the control group with the least average followed group caffeine in cocoa 2.3 mg (OWC1), 3.45 mg (OWC2), and 4.6 mg (OWC3) (p<0.05). Conclusion: This study confirmed that caffeine in cocoa administration increase TGF-β1 level during orthodontics tooth movement on Cavia cobaya in the pressure side.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%