TGFβ Superfamily Members as Regulators of B Cell Development and Function—Implications for Autoimmunity

Tamayo, Esther; Álvarez, Pilar; Merino, Ramón

doi:10.3390/ijms19123928

Cited by 58 publications

(43 citation statements)

References 142 publications

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“…TGF-β can also affect B cell development by regulating the differentiation, proliferation, and apoptosis of B cells [ 113 ]. In addition, it is also one of the cytokines that dictate the immunoglobulin IgM to IgA class switching in B cells.…”

Section: Tgf-β In Immune Surveillancementioning

confidence: 99%

Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity

Xue

Chung

Córdoba

et al. 2020

Cancers

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Transforming growth factor-β (TGF-β) was originally identified as an anti-tumour cytokine. However, there is increasing evidence that it has important roles in the tumour microenvironment (TME) in facilitating cancer progression. TGF-β actively shapes the TME via modulating the host immunity. These actions are highly cell-type specific and complicated, involving both canonical and non-canonical pathways. In this review, we systemically update how TGF-β signalling acts as a checkpoint regulator for cancer immunomodulation. A better appreciation of the underlying pathogenic mechanisms at the molecular level can lead to the discovery of novel and more effective therapeutic strategies for cancer.

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Section: Tgf-β In Immune Surveillancementioning

confidence: 99%

Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity

Xue

Chung

Córdoba

et al. 2020

Cancers

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“…Genes involved in B cell proliferation and activation were further investigated. It is interesting to note that Cr2 , a well-known complement receptor which form a co-receptor on B cells during antigen-induced activation, 48 was significantly upregulated; Tgfb1 , a potent regulator of B cells development from pre-B cells to immunoglobin secreting plasma cells, 49 was significantly down-regulated Figure 4e . Accumulating evidences indicate that secreted tumor products can also influence on distant immunological compartments, including lymphopoiesis.…”

Section: Resultsmentioning

confidence: 99%

Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes

Chen

et al. 2020

OncoImmunology

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Lymph-node metastasis is a prognosis factor for poor clinical outcome of breast cancer patients. Currently, how breast cancer cells establish pre-metastatic niche in the tumor-draining lymph nodes (TDLNs) is still unclear. To address this question, we isolated heterogeneous cells including immune and stromal cells from naive lymph nodes (LNs) of the FVB/NJ mice and TDLNs of the MMTV-PyMT mice. Single-cell RNA sequencing was performed to investigate the transcriptome of the cells and various bioinformatics analyses were used to identify the altered pathways. Our results revealed several significant changes between naïve LNs and TDLNs. First, according to immunologic signature and pathway analysis, CD4+ and CD8 + T cells showed upregulated angiogenesis pathway genes and higher regulatory T (Treg)-associated genes while they demonstrated downregulation of interferon response and inflammatory response gene signatures, concurrently suggesting an immunosuppressive microenvironment in the TDLNs. Second, profiling of B cells showed down-regulation of marginal zone B lymphocytes in the TDLNs, which was validated by flow cytometric analysis. Third, we found the enhancement of oxidative phosphorylation pathway in the fibroblastic reticular cells (FRCs) of the MMTV-PyMT mice and the elevation of related genes including Prdx3, Ndufa4 and Uqcrb, suggesting massive ATP consumption and TCA cycle metabolism in the FRCs. Collectively, our results reveal the reprogramming of TDLNs during breast cancer progression at single-cell level in a spontaneous breast cancer model and suggest the changes in immune modulation and metabolic switch are key alterations in the preparation of pre-metastatic niche by breast cancer cells.

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“…The expression of VEGFα and TGFB3 was modulated significantly under our experimental conditions. VEGFα plays a key role in the regulation of cell proliferation during the angiogenesis process [ 40 , 41 ] and TGFB3 is involved in cell migration [ 42 ]. Our results showed significant increased expression of VEGFα and TGFB3 in fibroblasts treated with ACCB under oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Marine Fungus Aspergillus chevalieri TM2-S6 Extract Protects Skin Fibroblasts from Oxidative Stress

Letsiou¹,

Bakea²,

Goff

et al. 2020

Marine Drugs

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The strain Aspergillus chevalieri TM2-S6 was isolated from the sponge Axinella and identified according to internal transcribed spacer (ITS) molecular sequence homology with Aspergillus species from the section Restricti. The strain was cultivated 9 days on potato dextrose broth (PDB), and the medium evaluated as antioxidant on primary normal human dermal fibroblasts (NHDF). The cultivation broth was submitted to sterile filtration, lyophilized and used without any further processing to give the Aspergillus chevalieri TM2-S6 cultivation broth ingredient named ACBB. ACCB contains two main compounds: tetrahydroauroglaucin and flavoglaucin. Under oxidative stress, ACCB showed a significant promotion of cell viability. To elucidate the mechanism of action, the impact on a panel of hundreds of genes involved in fibroblast physiology was evaluated. Thus, ACCB stimulates cell proliferation (VEGFA, TGFB3), antioxidant response (GPX1, SOD1, NRF2), and extracellular matrix organization (COL1A1, COL3A1, CD44, MMP14). ACCD also reduced aging (SIRT1, SIRT2, FOXO3). These findings indicate that Aspergillus chevalieri TM2-S6 cultivation broth exhibits significant in vitro skin protection of human fibroblasts under oxidative stress, making it a potential cosmetic ingredient.

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TGFβ Superfamily Members as Regulators of B Cell Development and Function—Implications for Autoimmunity

Cited by 58 publications

References 142 publications

Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity

Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity

Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes

Marine Fungus Aspergillus chevalieri TM2-S6 Extract Protects Skin Fibroblasts from Oxidative Stress

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