Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma

Liú, Dan; Tan, Yurong; Bajinka, Ousman; Wang, Lili; Tang, Zhongxiang

doi:10.1007/s11882-020-00903-x

Cited by 32 publications

(31 citation statements)

References 72 publications

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“…Our results indicated that B. infantis can restore the Th17/Treg balance. Th17 cells are an important component of the intestinal innate immune barrier, and their production depends on the presence of normal microbiota [24]. Treg cells and related factors IL-10 and TGF-β play an important role in the immune tolerance to the intestinal microbiota [25,26].…”

Section: Discussionmentioning

confidence: 99%

Pathogenic mechanism of intestinal microbiota involved in Guillain-Barre syndrome and with Bifidobacterium intervention

Shi

Nian

et al. 2021

Arch Med Sci

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IntroductionGuillain-barre syndrome (GBS) is an acute immune-mediated polyneuropathy, involving the peripheral nervous system. The pathogenicity of GBS lies on Th17/Treg imbalance which may be affected by intestinal microbiota. From the previous study, treatment with Bifidobacterium infantis (B. infantis) significantly improved the symptoms of experimental autoimmune neuritis (EAN) through reducing the levels of IL-17A. In the present study, we aimed to further investigate the pathogenic mechanisms of intestinal microbiota involved in GBS, with the intervention of Bifidobacterium.Material and methodsLewis rats (n = 18) were injected with P253-78 peptide and completed Freund's adjuvant to induce EAN model. The clinical scores, Hematoxylin–eosin (HE) staining and transmission electron microscopy at day 15 after immunization were used to determine the pathological changes. The levels of IL-17, IL-10 and TGF-β and the proportions of Th17 and Treg cells in lymphocytes of blood samples were used to decide the Th17 / Treg imbalance. The intestinal microbiota was detected using 16S rRNA technology, and the bacteria with significant changes were also detected in fecal specimens of GBS patients.ResultsB. infantis improved EAN, by decreasing clinical scores and pathological changes, thus improving Th17/Treg imbalance. Moreover, the number of Lactobacillus, Rumenococcus and Clostridium were significantly reduced whereas the number of Akkermansia, Escherichia and Coprococcus significantly increased in the EAN group, which was abrogated by B. infantis.ConclusionsImbalance of Th17/Tregs expression induced by imbalance of intestinal microbiota may get involved in GBS. However, B. infantis intervention can regulate Th17/Treg balance by regulating imbalanced intestinal microbiota, thus improving GBS.

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Section: Discussionmentioning

confidence: 99%

Pathogenic mechanism of intestinal microbiota involved in Guillain-Barre syndrome and with Bifidobacterium intervention

Shi

Nian

et al. 2021

Arch Med Sci

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“…Compromising selective absorption and triggers the onset of metabolic endotoxemia (Martinez-Medina et al 2014 ) PUFA and conjugated linoleic acid (CLA), phytochemicals, Mediterranean diet A high-protein diet a Potentially toxic substances such as sulfide, indole, ammonia and N -nitroso compounds) Deleterious and toxic for the intestine (Martínez et al 2010 ) PUFA and conjugated linoleic acid (CLA), phytochemicals, Mediterranean diet Excess dietary intake of protein and amino acids a Synthesis of nitric oxide (NO) Development of an obesity-associated microbiota, ulcerative colitis (Martinez-Medina et al 2014 ), lead to DNA damage (Martinez-Medina et al 2014 ; Irrazábal et al 2014 ) PUFA and conjugated linoleic acid (CLA) due to anti-inflammatory characteristic Excess nutrient intake a Firmicutes Obesity related to inflammatory metabolic disorders culminating from dysbiosis (Frank et al 2007 ) Probiotic ( Lactobacillus paracasei ) a circulating levels of ANGPTL4 and reduces body fat Vitamin D deficiency Induced dysbiosis in the gut microbiota Play a role in the pathogenesis of IBD and a risk of colitis (Ananthakrishnan 2015 ) Vitamin D supplementation had an anti-inflammation due to the inhibition of pro inflammatory genes such as TNF genes Red meat (thiol-containing amino acids) a Sulfate-reducing bacteria (e.g. Desulfovibrio spp., in the intestine b Mucus formation, inhibits methylation of DNA and a the generation of reactive oxygen species (Ananthakrishnan 2015 ) Stress such as exercise under sun or heat exposure) is recommended Saturated fatty acids and low in polyunsaturated fatty acids (vegetable oil) mouse model a Bilophilawadsworthia Inflammatory reaction mediated by Th1 cells and colitis, high bad low-density lipoprotein (LDL) cholesterol level (Ananthakrishnan 2015 ; Liu et al 2020 ) Feeding on mono-saturated fats and polyunsaturated fatty acids (ve...…”

Section: The Scoioeconomic Statusmentioning

confidence: 99%

Extrinsic factors influencing gut microbes, the immediate consequences and restoring eubiosis

et al. 2020

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From the emerging studies, the more diverse the microbial population in the gut, the healthier the gut. Health benefits are associated with the functional characteristics of these diverse microbial genes. Extrinsic factors causing dysbiosis are extensively studied however, linking the varying degree of consequences to the respective factors and therapeutic possibilities are not explored at length. This review aims to examine from previous studies and put forward the types of dysbiosis, the immediate consequences and the scientific approaches to restore disrupted microbiota. Dietary supplements are found to be one of the factors contributing profoundly to the alteration of gut microbiota. While diet rich in fibre and fermented food established a diverse microbiome and produce vital metabolites, high fat, animal proteins and high caloric carbohydrate are as well relative to dysbiosis among infants, adult or diseases individuals. The intermittent fasting, feeding methods, the pH and water quality are among the factors associated with dysbiosis. Prebiotics and Probiotics maintain and restore gut homeostasis. Antibiotic-induced dysbiosis are relatively on the spectrum of activity, the pharmacokinetics properties, the dose taken during the treatment route of administration and the duration of drug therapy. The higher the altitude, the lesser the diversity. Extreme temperatures as well are related to reduced microbial activity and metabolism. Delivery through caserium-section deprived the newborn from restoring valuable vaginal bacterial species and the baby will instead assumed intestinal microbiota-like. While exercise and oxidative stress contribute even though moderately, fecal microbial transfer (FMT) also influence gut microbiota.

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“…Innate immunity of gut epithelium harbors enterocytes that express pattern recognition receptors (PRRs). PRRs sense microbes-associated molecular patterns (MAMPs) and promote the production of anti-microbial peptides, recruitment of immune cells and transportation of sIgAs as immune response (Liu et al 2020). Various PRRs determine the sensing-response system of the host.…”

Section: Innate Immunitymentioning

confidence: 99%

Gut microbiota and the human gut physiological changes

et al. 2020

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Background The human gut can be colonized by number of microorganisms. The most studied are bacteria, which changes from birth to newborn born into adult-like gut microbiota. Much is known about the effects of dietary, medications, and lifestyles on the bacterial composition. However, the host physiological changes influencing the gut microbiota, the immediate consequences, and the possible gut microbiota therapy are not studied at length. This review is based profoundly on animal model studies through experimentation and some human clinical trials for the past 20 years. Forward The physiological factors studied to influences gut microbiota are bacterial mucosal receptors, mucin glycosylation, mucus, epithelial microvilli, and tight junction. Host secretions and immune response such as immunity, secretory A (sIgA), inflammasome, innate immunity, immune response, glycans, bile acids, peristalsis, microRNA, and adhesion to intestinal glycans are as well found to confer variety of alterations on gut microbial flora. Conclusion Despite the resilience of the gut microbiota in response to changes, chain of events causes the imbalance microbiota. Increased pro-inflammatory potential with the help of cell barriers, host secretions, and immune response mediate gut recovery.

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Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma

Cited by 32 publications

References 72 publications

Pathogenic mechanism of intestinal microbiota involved in Guillain-Barre syndrome and with Bifidobacterium intervention

Pathogenic mechanism of intestinal microbiota involved in Guillain-Barre syndrome and with Bifidobacterium intervention

Extrinsic factors influencing gut microbes, the immediate consequences and restoring eubiosis

Gut microbiota and the human gut physiological changes

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