The 99th percentile upper reference limit for the 5th generation cardiac troponin T assay in the United States

Fitzgerald, Robert L.; Hollander, Judd E.; Peacock, W. Frank; Breitenbeck, Nancy; Rivers, E. Joy; Ziegler, André; Laimighofer, Michael; deFilippi, Christopher R.

doi:10.1016/j.cca.2020.01.027

Cited by 13 publications

(7 citation statements)

References 43 publications

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“…These findings were in favor of a study done in Singapore and reported 99 th percentile cut-off value of 25.6ng/L for overall and 32.7ng/L and 17.9ng/L for male and female respectively 4 . Our study is also consistent with results of a study done in USA where 99th percentile URL ranged from 18.4-20.2ng/L in overall cases 5 .…”

Section: Discussionsupporting

confidence: 92%

To Study the 99th Percentile Upper Reference Limit of High Sensitive Troponin T in adult population of Multan

Khan¹,

Hafeez²,

Khan³

et al. 2022

PJMHS

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Aim: To determine 99th percentile upper reference limit of high sensitive Troponin T in adult population of Multan Methodology: A cross sectional study conducted in the department of chemical pathology, CMH, Multan from September 2021 to March 2022. Approval by the institutional review board was taken. Sample size was 265 cases. Results: Mean age was 46.2 + 12.7 years. 131(49.6%) were females and 134 (50%) were males. In 265 cases, there were 210 (79.24%) cases who had hs-TnT level of >2.99 ng/L and 55 (20.75%) have values of hs-TnT <3.0 ng/L. Cases having a level of <3.0 were assigned a value of 2.9 ng/L for statistical analysis. Kruskal-Wallis test was used to analyze significance in troponin level regarding age and gender. hs-cTnT values were found statistically significant between genders while non significant difference between age groups. Conclusion: hs-cTnT value was 18.20 ng/L in the study cases while these values were 30.46ng/L for males and 16.77ng/L for females. It is concluded that overall 99th percentile values of hs-cTnT are significantly higher among men as compared to women. Key words: High sensitive Troponin T, Adults, percentile

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Section: Discussionsupporting

confidence: 92%

To Study the 99th Percentile Upper Reference Limit of High Sensitive Troponin T in adult population of Multan

Khan¹,

Hafeez²,

Khan³

et al. 2022

PJMHS

View full text Add to dashboard Cite

show abstract

“…ED encounters from a large, tertiary, academic medical center showed that hs-cTnT values differed considerably by sex, race, age, CKD stage, and presence of atrial fibrillation and heart failure in patients without AMI. Our results from routine clinical care of non-AMI patients support data from healthy participants indicating that males have higher hs-cTnT values than females [2,4,5].…”

Section: Discussionsupporting

confidence: 84%

“…The relationship between race and hs-cTnT is even less clear in the literature. Data from healthy participants have shown multiple different relationships with some studies suggesting no difference or lower hs-cTnT levels in African Americans compared with Caucasians whereas others have seen increased levels of hs-cTnT in African Americans [ 2 , 5 ]. A sub-study of the Dallas Heart Study (DHS), a multiethnic, population cohort of residents in Dallas County, showed that black women had higher hs-cTnT levels but after adjustment this relationship disappeared [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Author details 1 Department of Medicine, The University of Chicago, Chicago, IL, USA. 2 Department of Medicine, Section of Cardiology, The University of Chicago, 5841 South Maryland Avenue, MC6080, Chicago, IL 60637, USA. 3 Department of Data Science and Analytics, The University of Chicago Medicine, Chicago, IL, USA.…”

Section: Supplementary Informationmentioning

confidence: 99%

“…Since the approval of the high-sensitivity cardiac troponin-T (hs-cTnT) assay by the US Food and Drug Administration in 2017 for clinical care, there has been renewed interest in determining blood concentrations in individuals without acute myocardial infarctions (AMI) [1,2]. Studies have suggested that hs-cTnT levels vary by sex, race, age, and degree of kidney function [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A retrospective analysis of high sensitivity cardiac troponin-T ranges in non-myocardial infarction emergency department visits

Kong

Chua

Besser

et al. 2021

BMC Cardiovasc Disord

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Introduction Current evidence suggests that high sensitivity cardiac troponin-T (hs-cTnT) values differ based on sex, race, age, and kidney function. However, most studies examining the relationship of hs-cTnT and these individual factors are in healthy participants, leading to difficulty in interpreting hs-cTnT values in the Emergency Department (ED) setting. We seek to examine the relationship between hs-cTnT values and sex, race, age, and kidney function in a contemporary, urban academic setting. Methods ED visits from June 2018 through April 2019 with at least 1 hs-cTnT and no diagnosis of acute myocardial infarction (AMI) at an academic medical center in the south side of Chicago were retrospectively analyzed. Median hs-cTnT values were stratified by sex (male or female), race (African American or Caucasian), age, estimated glomerular filtration rate (eGFR), and stage of chronic kidney disease. Results 9679 encounters, representing 7989 distinct patients, were included for analysis (age 58 ± 18 years, 59% female, 85% black). Males had significantly higher median hs-cTnT values than females (16 [8–34] vs. 9 [6–22] ng/L, p < 0.001), African Americans had a significantly lower median value than Caucasians (10 [6–24] vs. 15 [6–29] ng/L, p < 0.001), and those with atrial fibrillation (27 [16–48] vs. 9 [6–19] ng/L, p < 0.001) and heart failure (28 [14–48] vs. 8 [6–15] ng/L, p < 0.001) had higher median values than those without. Median hs-cTnT values increased significantly with increased age and decreased eGFR. All relationships continued to be significant even after multivariable regression of sex, age, race, eGFR, presence of atrial fibrillation, and presence of heart failure (p < 0.01). Conclusions Analysis of hs-cTnT in non-AMI patients during ED encounters showed that males have higher values than females, African Americans have lower values than Caucasians, those with atrial fibrillation and heart failure have higher values than those without, and that older age and lower eGFR were associated with higher median values.

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The Laboratory Diagnosis of Myocardial Infarction and Heart Failure

Bailey,

Fitzgerald

2024

Clinical Chemistry

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The 99th percentile upper reference limit for the 5th generation cardiac troponin T assay in the United States

Cited by 13 publications

References 43 publications

To Study the 99th Percentile Upper Reference Limit of High Sensitive Troponin T in adult population of Multan

To Study the 99th Percentile Upper Reference Limit of High Sensitive Troponin T in adult population of Multan

A retrospective analysis of high sensitivity cardiac troponin-T ranges in non-myocardial infarction emergency department visits

The Laboratory Diagnosis of Myocardial Infarction and Heart Failure

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