The A5.1 allele of the major histocompatibility complex class I chain-related gene A is associated with psoriasis vulgaris in Chinese

Cheng, Ling Jie; Zhang, S.Z.; Xiao, Cuiying; Hou, Yiping; Li, L.; Luo, Hongwei; Jiang, Hong; Zuo, Wang

doi:10.1046/j.1365-2133.2000.03658.x

Cited by 40 publications

(28 citation statements)

References 22 publications

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“…For example, MIC molecules have previously been shown to associate with psoriasis. These molecules are in fact recognized by NK/NKT cells as their expression seems to be triggered by low levels of HLA class I expression (Cheng et al, 2000;Dunn et al, 2000). It will therefore be important to determine whether HLA-C and MIC, and perhaps other immune molecules interact in psoriasis pathogenesis.…”

Section: Discussionmentioning

confidence: 98%

Distinct HLA-C/KIR Genotype Profile Associates with Guttate Psoriasis

Holm

Sakuraba

Mallbris

et al. 2005

Journal of Investigative Dermatology

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Psoriasis is a multifactorial disease with a strong genetic background. It associates strongly to HLA-Cw*0602. HLA-C interacts with killer immunoglobulin-like receptors (KIR) on natural killer (NK) and some natural killer-T (NKT) cells. KIR's function is triggered by specific binding to HLA ligands, which depends on the amino acid 80 of the MHC class I alpha-chain. This permits classifying all HLA-C alleles into two functional groups: asparagine (N80) or lysine (K80) carrying alleles. Psoriasis patients recruited at disease onset were categorized as guttate, vulgaris without arthropathy and vulgaris with arthropathy plus skin lesions. Patients and carefully matched controls were genotyped for position 80 of HLA-C and for KIR. Based on possible HLA/KIR combinations, individuals were classified according to expected NK/NKT cell responses: balanced (B), excess inhibition (EI), excess activation (EA), or undetermined (U). HLA-Cw6 and position 80 genotyping associated strongly to disease, whereas KIR2DS1 associated weakly. Individuals of the U and EI classes were more common among guttate psoriasis patients, which related to HLA-Cw*0602 status. These results suggest that different levels for NK/NKT cell activation thresholds, not only reduction, contribute to immune deregulation in psoriasis. In the guttate phenotype, balanced HLA-C/KIR interactions might be altered by the presence of concomitant streptococcal infections.

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Section: Discussionmentioning

confidence: 98%

Distinct HLA-C/KIR Genotype Profile Associates with Guttate Psoriasis

Holm

Sakuraba

Mallbris

et al. 2005

Journal of Investigative Dermatology

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“…HLA-E is a nonclassical class I molecule that provides a ligand for NKG2A/CD94, and NKG2C/CD94 receptors expressed by NK cells, and MICA encodes an antigen expressed in response to stress or particular pathological situations that activates NK cells through ligation of NKG2D [52]. An allele of MICA that possibly encodes for a soluble receptor, termed MICA A5.1, is associated with an increased risk of Psoriasis Vulgaris in a Chinese patient cohort [53]. Although there has been some controversy in the literature [6, 54], it seems likely that HLA-Cw6 constitutes the actual risk variant rather than acting as a marker for a nearby gene that is responsible for the effects seen.…”

Section: Recent Advances In Genetic Analysis Of Psoriasismentioning

confidence: 99%

NK Cells and Psoriasis

Dunphy

Gardiner

2011

BioMed Research International

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Psoriasis is a chronic condition of the skin characterised by distinctive scaly plaques. The immune system is now thought to play a major role in the development and pathogenesis of psoriasis with immune cells and cytokines influencing keratinocyte function. Keratinocytes in turn, can activate and recruit immune cells leading to a positive feedback loop in disease. Natural Killer (NK) cells are lymphocytes that are best known for killing virally infected and cancer cells. However, evidence is emerging to support a role for NK cells in psoriasis. NK cells are found in the inflammatory infiltrate in psoriatic skin lesions. They can produce a range of inflammatory cytokines, many of which are important in the pathogenesis of psoriasis. Recent genetic studies have identified a range of potential molecules relating to NK cell biology that are known to be important in psoriasis. This paper will discuss the evidence, both cellular and genetic, for NK cell involvement in psoriasis.

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“…One Australian study found an association between Type I psoriasis and the MICA allele which has nine GCT repeats (A9) and a guanine deletion at the beginning of intron 4 [25]. Other studies in Chinese and Korean patients have shown an association between the truncated form of the protein, A5.1, and Type I psoriasis [26,27]. None of these studies looked for the presence of arthritis complicating the psoriasis.…”

Section: Micamentioning

confidence: 95%

Genetic factors in psoriatic arthritis

Korendowych

McHugh²

2005

Curr Rheumatol Rep

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The genetic factors that are associated with psoriatic arthritis (PsA) are intricately linked with those that predispose to psoriasis itself. The strongest association is with human leukocyte antigen-Cw*0602, although true susceptibility may lie with one of the neighboring genes along a disease-associated haplotype. There are a number of interesting candidate genes within the major histocompatibility complex (MHC) region with strong functional relevance that have been investigated in PsA. In addition, several areas outside the MHC complex have been highlighted as a result of genetic linkage studies in psoriasis. PsA is a complex, multifactorial disease where multiple genes are likely to influence disease susceptibility, severity, and clinical phenotype. The current evidence for genetic factors in psoriasis and PsA will be reviewed.

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The A5.1 allele of the major histocompatibility complex class I chain-related gene A is associated with psoriasis vulgaris in Chinese

Abstract: These results suggest that the MICA gene may be associated with the development of PS in Chinese.

Cited by 40 publications

References 22 publications

Distinct HLA-C/KIR Genotype Profile Associates with Guttate Psoriasis

Distinct HLA-C/KIR Genotype Profile Associates with Guttate Psoriasis

NK Cells and Psoriasis

Genetic factors in psoriatic arthritis

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