The Accuracy of Adherence Self-report Scales in Patients on Thiopurines for Inflammatory Bowel Disease: A Comparison With Drug Metabolite Levels and Medication Possession Ratios

Association of Self-Reported Medication Adherence with Potentially Inappropriate Medications in Elderly Patients: A Cross-Sectional Pilot Study

“…In our hospital, since 1 September 2019, pharmacists have measured the VAS score of hospitalized patients at admission as routine work and, as a result, have provided better medication counseling to these patients than before. The VAS is used to assess medication adherence and shows high median or mean scores in a variety of populations: patients taking antidiabetes (median, 95.9%) and lipid-modifying (median, 95.2%) drugs [48]; hypertension/type 2 diabetes mellitus/dyslipidemia patients (mean, 91.3%) [51]; patients taking at least one hypertensive medication (median, 100%) [56]; IBD, including ulcerative colitis or Crohn's disease, patients (median, 91-100%) [50,54,57,58]; rheumatoid arthritis patients taking methotrexate (median, 94%) [59]; patients taking warfarin (mean, 92.2-96.6%) [49,60]; patients admitted to the psychiatric ward (mean, 86%) [61]; glaucoma patients (median, 95.0%) [62]; postmenopausal women with hormone receptor-positive breast cancer taking aromatase inhibitors (median, 100%) [63]; human immunodeficiency virus patients undergoing antiretroviral therapy (94-100%) [53,64]. Our median VAS score of 98% was high, similar to previous studies, probably because the study participants were self-administering elderly patients who were highly motivated to take their medications, leading to a high VAS score.…”

“…The VAS has moderate concordance with the claim-based measure in patients taking antidiabetes and lipid-modifying drugs [48], and there is a significant association between the VAS score and anticoagulation control in patients who were treated with warfarin [49]. Selinger et al (2019) assessed four adherence measurement tools, including VAS, Medication Adherence Report Scale, Medication Possession Ratio, and blood level of thiopurine metabolites in inflammatory bowel disease (IBD) patients and found that all four methods significantly associated with each other [54]. In some of the previous studies, a cut-off value of 80% was used to divide medication adherence into good or poor [48][49][50][51], while other studies used a cut-off value of 100% [52,53].…”

Adherence to Azathioprine/6-Mercaptopurine in Children and Adolescents with Inflammatory Bowel Diseases: A Multimethod Study

“…e self-reported questionnaires provide a more longitudinal assessment, that is, being not specific to the short period leading up to the clinic visit. e MARS is a validated tool to assess adherence in a different illness population [21,22,[27][28][29] including IBD patients [18,39] and can be used as a screening tool in clinical practice [39]. Child selfreported nonadherence (39.4%) was higher than parent/ guardian reported nonadherence (21.3%), the difference being statistically significant (p � 0.013).…”

Factors Associated with Self-reported Medication Adherence in Japanese Community-dwelling Elderly Individuals: The Nakajima Study

“…17) However, there is a possibility that these results may be overestimated because of the variation between subjective and objective evaluations. 18,19) The cut-oŠ point for medication adherence using VAS was 80 100％ in previous studies 17,20 25) and is generally 80％; however, this threshold is not always appropriate as it has been arbitrarily deˆned 26) and varies for diŠerent diseases. 27,28) Meanwhile, the median VAS score in previous studies were 91 100％ 17,20 25,29 32) because of overestimation of selfreported data.…”