The Activity of Adiponectin in Bone

Naot, Dorit; Musson, David S.; Cornish, Jillian

doi:10.1007/s00223-016-0216-5

Cited by 62 publications

(50 citation statements)

References 64 publications

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“…Others have consistently shown circulating adiponectin levels to be inversely correlated with BMD (Naot et al. ), which we now show to be increased in low protein offspring at 6 weeks of age. It is possible the described hormonal changes were directly responsible for the changes to bone growth and development observed.…”

Section: Discussionsupporting

confidence: 79%

Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge

et al. 2019

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Epidemiological studies suggest skeletal growth is programmed during intrauterine and early postnatal life. We hypothesize that bone development may be altered by maternal diet and have investigated this using a microswine model of maternal protein restriction (MPR). Mothers were fed a control diet (14% protein) or isocaloric low (1%) protein diet during late pregnancy and for 2 weeks postnatally. Offspring were weaned at 4 weeks of age to ad lib or calorie‐restricted food intake groups. Femur and vertebra were analysed by micro computed tomography in offspring 3–5 months of age. Caloric restriction from 4 weeks of age, designed to prevent catch‐up growth, showed no significant effects on bone structure in the offspring from either maternal dietary group. A maternal low protein diet altered trabecular number in the proximal femur and vertebra in juvenile offspring. Cortical bone was unaffected. These results further support the need to understand the key role of the nutritional environment in early development on programming of skeletal development and consequences in later life.

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Section: Discussionsupporting

confidence: 79%

Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge

et al. 2019

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“…In this regard, adiponectin levels are generally decreased in obese, insulin-resistant, and type 2 diabetes patients [16]. Extensive research has also brought to light the physiological role of Acrp30 in bone metabolism [17]. In particular, analyzing Acrp30 endocrine effects on the skeletal system in women, an inverse correlation between its serum concentration and bone mineral density (BMD) has clearly been demonstrated in different clinical studies [18,19].…”

Section: Introductionmentioning

confidence: 99%

AdipoRon Affects Cell Cycle Progression and Inhibits Proliferation in Human Osteosarcoma Cells

Sapio

Nigro

Ragone

et al. 2020

Journal of Oncology

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AdipoRon (AdipoR) is the first synthetic molecule acting as a selective and potent adiponectin receptor agonist. Recently, the possible pharmacological use of AdipoR in different pathological conditions has been addressed. Interestingly, initial evidence suggests that AdipoR may have anticancer properties in different preclinical models, such as pancreatic and ovarian cancer. To our knowledge, so far no research has been directed at determining the impact of AdipoR on osteosarcoma, the most aggressive and metastatic bone malignancy occurring in childhood and adolescence age. Here, we investigate the possible antitumor effects of AdipoR in osteosarcoma cell lines. MTT and cell growth curve assays clearly indicate that AdipoR inhibits, at different extents, proliferation in both U2OS and Saos-2 osteosarcoma cell lines, the latter being more sensitive. Moreover, flow cytometry-based assays point out a significant G0/G1 phase accumulation and a contemporary S phase decrease in response to AdipoR. Consistent with the different sensitivity, a strong subG1 appearance in Saos-2 after 48 and 72 hours of treatment is also observed. The investigation of the molecular mechanisms highlights a common and initial ERK1/2 activation in response to AdipoR in both Saos-2 and U2OS cells. Interestingly, a simultaneous and dramatic downregulation of p70S6K phosphorylation, one of the main targets of mTORC1 pathway, has also been observed in AdipoR-treated Saos-2, but not in U2OS cells. Importantly, a strengthening of AdipoR-induced effects was reported upon everolimus-mediated mTORC1 perturbation in U2OS cells. In conclusion, our findings provide initial evidence of AdipoR as an anticancer molecule differently affecting various signaling pathways involved in cell cycle and cell death in osteosarcoma cells and encourage the design of future studies to further understand its pattern of activities.

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“…In vitro studies have shown that ADP may regulate bone resorption and bone formation by affecting the proliferation and differentiation of osteoclasts and osteoblasts. A number of clinical observational studies have shown that ADP levels is negatively correlated with BMD, suggesting that it might be a negative regulator of bone metabolism [67], nevertheless, it still remains controversial in the study of human body. Thus, the interaction between ADP and OC on bone metabolism and glycolipid metabolism and the mechanism therein are unclear yet, which need to be further studied for a better understanding.…”

Section: Oc and Exercisementioning

confidence: 99%

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Yang

et al. 2019

Ann Nutr Metab

110

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Background: Exercise therapy plays an important role in the prevention and treatment of type 2 diabetes (T2DM). The mechanism of exercise therapy in the improvement of glycolipid metabolism of T2DM is very complex and not completely clear. Summary: Exercise training improves the whole body metabolic health in patients with T2DM, leading to an increase in glycolipid uptake and utilization, improved insulin sensitivity, optimized body mass index, and modulated DNA methylation, etc. Recent findings support that some cytokines such as irisin, osteocalcin, and adiponectin are closely related to exercise and metabolic diseases. This study briefly reviews the physiological mechanisms of exercise therapy in diabetes and the potential role of these cytokines in exercise. Key Messages: More high-quality, targeted, randomized controlled studies are needed urgently, from mechanism study to treatment direction, to provide a more theoretical basis for exercise therapy and to explore new therapeutic targets for diabetes.

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The Activity of Adiponectin in Bone

Cited by 62 publications

References 64 publications

Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge

Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge

AdipoRon Affects Cell Cycle Progression and Inhibits Proliferation in Human Osteosarcoma Cells

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

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