The Activity of Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase in the Sera of Patients with Autoimmune Hepatitis

Jelski, Wojciech; Wolszczak-Biedrzycka, Blanka; Zasimowicz-Majewska, Elżbieta; Orywal, Karolina; Piechota, Joanna; Łapiński, Tadeusz Wojciech; Bednarczyk, Marzena; Szmitkowski, Maciej

doi:10.7754/clin.lab.2017.170925

Cited by 6 publications

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“…We have also observed that ADH I activity was elevated in the serum of patients with metastatic liver cancer (8). Furthermore, we have reported that the activity of class I alcohol dehydrogenase was significantly higher in the serum of patients with autoimmune hepatitis or nonalcoholic fatty liver disease than in healthy controls (24,25). In our study, we excluded women with different hepatobiliary diseases.…”

Section: Discussionmentioning

confidence: 83%

The Alterations in Alcohol Dehydrogenase Activity in the Sera of Women With Intrahepatic Cholestasis of Pregnancy

et al. 2020

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Section: Discussionmentioning

confidence: 83%

The Alterations in Alcohol Dehydrogenase Activity in the Sera of Women With Intrahepatic Cholestasis of Pregnancy

et al. 2020

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“…Numerous studies have demonstrated changes in the activity of alcohol dehydrogenase (ADH), its isoenzymes and aldehyde dehydrogenase (ALDH) in the blood serum of patients with various liver diseases, including hepatitis C, liver tumors, fatty liver disease, and AIH (Chrostek and Szmitkowski 2000 ; Jelski et al 2008 , 2017 , 2018a , 2018b ). These liver diseases showed statistically higher activity of class I ADH and total ADH in the serum of patients than in healthy subjects and the results suggest a potential clinical role for ADH (especially class I ADH) as marker for liver disorders.…”

Section: Introductionmentioning

confidence: 99%

An Assessment of the Serum Activity of ADH and ALDH in Patients with Primary Biliary Cholangitis

Wolszczak-Biedrzycka

Bieńkowska

Zasimowicz³

et al. 2022

Arch. Immunol. Ther. Exp.

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Primary biliary cholangitis (PBC; previously known as primary biliary cirrhosis) is a chronic inflammation-induced cholestatic process in the liver. Antimitochondrial antibodies (AMAs) are observed in around 90% of patients, which suggests that PBC is an autoimmune disease. Alcohol dehydrogenase (ADH), ADH isoenzymes and aldehyde dehydrogenase (ALDH) are localized in the liver, and they are useful markers of liver dysfunction. In this study, the activity of total ADH, ADH isoenzymes and ALDH was evaluated in the blood serum of patients with PBC. The experimental group comprised 50 PBC patients, both male and female, aged 28–67. The control group consisted of 50 healthy subjects, both male and female, aged 25–65. The serum activity of class I ADH, class II ADH and ALDH was measured by spectrofluorophotometry, whereas total ADH and class III ADH activity was determined by photometry methods. The activity of class I ADH and total ADH was significantly higher in the experimental group than in the control group (p < 0.001). An increase in class I ADH and total ADH activity indicates that the isoenzyme class I ADH is released by compromised liver cells and can be useful diagnostic markers of PBC.

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“…In our previous investigations we have found that the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were significantly higher in the serum of patients with different liver diseases (e.g. hepatitis C, autoimmune hepatitis, fatty liver disease) than in healthy subjects (Jelski et al, 2018a;Jelski et al, 2018b;Jelski et al, 2018c).…”

Section: Introductionmentioning

confidence: 99%

The comparison of total bile acid concentration and alcohol dehydrogenase activity as markers of intrahepatic cholestasis of pregnancy

et al. 2021

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Introduction: Intrahepatic cholestasis of pregnancy (ICP) is the liver disorder in the second or early third trimester of pregnancy. It is characterized by pruritus with increased serum bile acids concentration and other liver function tests. ICP is connected with increased risk of fetal mortality, but is unfortunately detected quite late. Therefore, it is important to recognize the disease in its early stages. We aimed to investigate the serum alcohol dehydrogenase (ADH) activity and compare it with the concentration of total bile acid (TBA) in women with ICP. Methods: Serum samples were taken for routine investigation from 80 pregnancies with ICP in the second or third trimester of pregnancy and from 80 healthy pregnant women in the same time of pregnancy. For measurement of class I activity we used the spectrofluorometric methods. The total ADH activitiy was measured by the photometric method. Results: The analysis of results shows a statistically significant increase in the activity of ADH I and ADH total (about 60% and 41.3%, respectively). Activity of ADH I well correlated with aminotransferases (alanine ALT and aspartate AST) and total bile acids (TBA) concentration. The total ADH activity was also positively correlated with ALT, AST and total bile acids. Conclusion: We can state that the activity of class I alcohol dehydrogenase isoenzyme in the sera of patients with ICP is increased and seems to be a good indicator of liver cell destruction during this disease and is comparable with the value of other markers.

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The Activity of Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase in the Sera of Patients with Autoimmune Hepatitis

Abstract: The activity of total ADH and class I isoenzymes in the sera of patients with autoimmune hepatitis is increased, and it seems to be caused by the release of alcohol dehydrogenase from damaged liver cells.

Cited by 6 publications

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The Alterations in Alcohol Dehydrogenase Activity in the Sera of Women With Intrahepatic Cholestasis of Pregnancy

The Alterations in Alcohol Dehydrogenase Activity in the Sera of Women With Intrahepatic Cholestasis of Pregnancy

An Assessment of the Serum Activity of ADH and ALDH in Patients with Primary Biliary Cholangitis

The comparison of total bile acid concentration and alcohol dehydrogenase activity as markers of intrahepatic cholestasis of pregnancy

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