The acute effects of fine particulate matter constituents on circulating inflammatory biomarkers in healthy adults

Zhang, Qingli; Niu, Yue; Xia, Yongde; Lei, Xiaoning; Wang, Weidong; Huo, Juntao; Zhao, Qianbiao; Zhang, Yihua; Duan, Yusen; Cai, Jing; Zhao, Ying; Li, Shanqun; Chen, Renjie; Fu, Qingyan; Kan, Haidong

doi:10.1016/j.scitotenv.2019.135989

Cited by 57 publications

(42 citation statements)

References 38 publications

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“…However, evidence has suggested that the associations of PM 2.5 constituents with biomarkers of inflammation and oxidative stress, closely related to blood lipids, were always pronounced within lag 3 days, which is generally consistent with our results and provides indirect support for our findings concerning blood lipids. 34,60 In the present study, we did not find that constituents with large masses (EC, OC, and ions) were significantly associated with lipids. However, some transition metals, which account for a small fraction of PM 2.5 mass, were found to be related to changes in blood lipids.…”

Section: ■ Discussioncontrasting

confidence: 79%

Associations of Particulate Matter Sizes and Chemical Constituents with Blood Lipids: A Panel Study in Guangzhou, China

Guo

et al. 2021

Environ. Sci. Technol.

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Existing evidence is scarce concerning the various effects of different PM sizes and chemical constituents on blood lipids. A panel study that involved 88 healthy college students with five repeated measurements (440 blood samples in total) was performed. We measured mass concentrations of particulate matter with diameters ≤ 2.5 μm (PM2.5), ≤1.0 μm (PM1.0), and ≤0.5 μm (PM0.5) as well as number concentrations of particulate matter with diameters ≤ 0.2 μm (PN0.2) and ≤0.1 μm (PN0.1). We applied linear mixed-effect models to assess the associations between short-term exposure to different PM size fractions and PM2.5 constituents and seven lipid metrics. We found significant associations of greater concentrations of PM in different size fractions within 5 days before blood collection with lower high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A (ApoA1) levels, higher apolipoprotein B (ApoB) levels, and lower ApoA1/ApoB ratios. Among the PM2.5 constituents, we observed that higher concentrations of tin and lead were significantly associated with decreased HDL-C levels, and higher concentrations of nickel were associated with higher HDL-C levels. Our results suggest that short-term exposure to PM in different sizes was deleteriously associated with blood lipids. Some constituents, especially metals, might be the major contributors to the detrimental effects.

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Section: ■ Discussioncontrasting

confidence: 79%

Associations of Particulate Matter Sizes and Chemical Constituents with Blood Lipids: A Panel Study in Guangzhou, China

Guo

et al. 2021

Environ. Sci. Technol.

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“…One researcher found that elevated blood pressure is associated with ambient increased concentrations of OC, EC, nitrate, and ammonium in patients comorbid with chronic obstructive pulmonary disease 37 . In addition, the linkages between elevations of airway (fractional exhaled nitric oxide) 32 and circulating inflammatory biomarkers (interleukin-8, tumor necrosis factor-α, and monocyte chemoattractant protein-1) 38 and increased ambient concentrations of sulfate and potassium at lag 0-2 were identified and reported.…”

Section: Organic Carbonmentioning

confidence: 99%

Risk of ambulance services associated with ambient temperature, fine particulate and its constituents

Lin

Cheng

Kim

2021

Sci Rep

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Short-term adverse health effects of constituents of fine particles with aerodynamic diameters less than or equal to 2.5 μm (PM2.5) have been revealed. This study aimed to evaluate the real-time health outcome of ambulance services in association with ambient temperature and mass concentrations of total PM2.5 level and constituents in Kaohsiung City, an industrialized city with the worst air quality in Taiwan. Cumulative 6-day (lag0-5) relative risk (RR) and 95% confidence interval (CI) of daily ambulance services records of respiratory distress, coma and unconsciousness, chest pain, headaches/dizziness/vertigo/fainting/syncope, lying at public, and out-of-hospital cardiac arrest (OHCA) in association with ambient temperature and mass concentrations of total PM2.5 level and constituents (nitrate, sulfate, organic carbon (OC), and elemental carbon (EC)) from 2006 to 2010 were evaluated using a distributed lag non-linear model with quasi-Poisson function. Ambulance services of chest pain and OHCA were significantly associated with extreme high (30.8 °C) and low (18.2 °C) temperatures, with cumulative 6-day RRs ranging from 1.37 to 1.67 at the reference temperature of 24–25 °C. Daily total PM2.5 level had significant effects on ambulance services of lying at public and respiratory distress. After adjusting the cumulative 6-day effects of temperature and total PM2.5 level, RRs of ambulance services of lying at public associated with constituents at 90th percentile versus 25th percentile were 1.35 (95% CI: 1.08, 1.68) for sulfate and 1.20 (95% CI: 1.02, 1.41) for EC, while RR was 1.31 (95% CI: 1.09–1.58) for ambulance services of headache/dizziness/vertigo/fainting/syncope in association with OC at 90th percentile versus 25th percentile. Cause-specific ambulance services had various significant association with daily temperature, total PM2.5 level, and concentrations of constituents. Elemental carbon may have stronger associations with increased ambulance services than other constituents.

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“…Short-term exposure to PM 2.5 induces systemic inflammation and increases the circulation levels of inflammatory biomarkers such as CRP, tumor necrosis factor α (TNF-α), IL-6, IL-8 and MCP-1 [35,164]. PM 2.5 triggers the secretion of IL-6 and IL-1β by activating the TLRmediated pathway in HUVECs, while TLR2 and TLR4 inhibitors reduce the PM 2.5 -triggered inflammatory response [120].…”

Section: Ambient Pm 25 Induces An Inflammatory Responsementioning

confidence: 99%

“…In addition, the surface of particles may bind reactive copollutants, including biomolecules (such as endotoxins), redoxactive transition metals, and reactive quinones/aldehydes, which may be carried by particles and enter lung tissue and the circulation, inducing secondary toxicity [33,34]. The ions and metal components of PM 2.5 , including SO 4 2− , K + , Cl − , K, Si, As, Zn, Se and Pb, could be mainly responsible for systemic inflammation [35]. Evidence has shown that the binding of endotoxins to the surface of PM 2.5 particles plays a critical role in the inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

The critical role of endothelial function in fine particulate matter-induced atherosclerosis

et al. 2020

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Ambient and indoor air pollution contributes annually to approximately seven million premature deaths. Air pollution is a complex mixture of gaseous and particulate materials. In particular, fine particulate matter (PM2.5) plays a major mortality risk factor particularly on cardiovascular diseases through mechanisms of atherosclerosis, thrombosis and inflammation. A review on the PM2.5-induced atherosclerosis is needed to better understand the involved mechanisms. In this review, we summarized epidemiology and animal studies of PM2.5-induced atherosclerosis. Vascular endothelial injury is a critical early predictor of atherosclerosis. The evidence of mechanisms of PM2.5-induced atherosclerosis supports effects on vascular function. Thus, we summarized the main mechanisms of PM2.5-triggered vascular endothelial injury, which mainly involved three aspects, including vascular endothelial permeability, vasomotor function and vascular reparative capacity. Then we reviewed the relationship between PM2.5-induced endothelial injury and atherosclerosis. PM2.5-induced endothelial injury associated with inflammation, pro-coagulation and lipid deposition. Although the evidence of PM2.5-induced atherosclerosis is undergoing continual refinement, the mechanisms of PM2.5-triggered atherosclerosis are still limited, especially indoor PM2.5. Subsequent efforts of researchers are needed to improve the understanding of PM2.5 and atherosclerosis. Preventing or avoiding PM2.5-induced endothelial damage may greatly reduce the occurrence and development of atherosclerosis.

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The acute effects of fine particulate matter constituents on circulating inflammatory biomarkers in healthy adults

Cited by 57 publications

References 38 publications

Associations of Particulate Matter Sizes and Chemical Constituents with Blood Lipids: A Panel Study in Guangzhou, China

Associations of Particulate Matter Sizes and Chemical Constituents with Blood Lipids: A Panel Study in Guangzhou, China

Risk of ambulance services associated with ambient temperature, fine particulate and its constituents

The critical role of endothelial function in fine particulate matter-induced atherosclerosis

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