The Addition of Secondary Amines to Some α-Benzal Ketones

Ordered organo-inorganic hybrid mesoporous solid acid catalysts (Zr–TMS–TFA) for Michael addition of indoles with α,β-unsaturated carbonyl compounds under environmentally benign solvent free conditions

“…Also, nitrogen-containing compounds are of significant importance in biologically active substances, dyes, and fine chemicals [6,7]. Further, the b-amino carbonyl group is a common moiety in a large variety of biologically active compounds such as alkaloids and polyketides [8][9][10][11]. They serve as attractive precursors in the preparation of c-amino alcohol, b-lactams, bamino acid derivatives and chiral auxiliaries [12][13][14][15][16], where many of which serve as antibiotics or other drugs [17][18][19].…”

Regioselective Synthesis of Dispirocycloalkanooxindolopyrrolidines and Dispirocyclalkanoindanopyrrolidines

“…Thus, arylidene cycloheptanones 4a-d and arylidene cyclooctanones 4e-h were prepared by condensation of cycloheptanone and cyclooctanone, respectively, with aromatic aldehydes in the presence of a base catalyst. [17,18] The geometry of the olefinic double bond was found to be E configuration in all cases, as evidenced by 1 H NMR spectra.…”

ZrOCl2·8H2O as a highly efficient and the moisture tolerant Lewis acid catalyst for Michael addition of amines and indoles to α, β-unsaturated ketones under solvent-free conditions

“…In addition, nitrogen-containing compounds are of significant importance in human life and also they are useful as biologically active substances, dyes, and fine chemicals [3]. For instance, the ␤-amino carbonyl group is a common moiety in a large variety of biologically active compounds such as alkaloids and polyketides [4][5][6][7]. They are also attractive precursors in preparation of ␥-amino alcohols, ␤-lactams, ␤-aminoacid derivatives and chiral auxiliaries [8][9][10][11][12][13], many of which serve as powerful antibiotics or other drugs [14].…”