The additive analgesic efficacy of acetaminophen,1000 mg, and codeine, 60 mg, in dental pain

Abstract

In a double-blind, randomized, single-dose trial the analgesic contribution of acetaminophen, 1000 mg, and codeine, 60 mg, was determined. The study was a 2 X 2 factorial experiment in which 120 patients suffering from pain as a result of oral surgery rated their pain intensity and pain relief for up to 5 hours after a single dose of one of: 1000 mg acetaminophen, 60 mg codeine, 1000 mg acetaminophen plus 60 mg codeine, or placebo. The factorial analysis showed that both 1000 mg acetaminophen and 60 mg codeine made a statistically significant (P less than 0.05) contribution to the analgesic effectiveness of the combination on all measures of efficacy (sum of pain intensity differences, largest pain intensity difference, total pain relief, largest pain relief, and time to remedication). The incidence of adverse effects did not appear to differ among the treatments, including placebo.

Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic review

“…Five reports were excluded from analysis: two abstracts were later published as full papers,12 13 one report was a summary of an earlier published trial,14 and in two reports the abstract and text differed in the dose of paracetamol used 15 16. The 24 studies included in the review were assessed for methodological quality 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40. Differences in the assessments were resolved by discussion and the assessors reached full agreement in all cases.…”

The potentiation of analgesic activity of paracetamol plus morphine involves the serotonergic system in rat brain

“…monaminergic and peptidergic) may interact to modulate and perform many behavioural changes including nociception [22]. The results obtained using this experimental procedure could thus probably be transferred to human beings; in fact, in human therapeutics as well there are products indicated for mild pain containing PARA and opiate derivatives (like codeine) at ineffective doses when used alone [47].…”

Paracetamol: New Vistas of an Old Drug

“…The dose of 1,000 mg was effective for up to 5 h after oral surgery (134), although pain relief was maximal at 1 to 2 h after administration (22), and was shown to be an effective treatment for extraction of impacted third molars and for various other oral surgeries, including difficult extractions, alveolectomy, multiple extractions, apicoectomy, biopsy, and deep gingival curettage (135,196).…”