The adsorption of pepsin

Piper, D. W.; Fenton, Barbara H.

doi:10.1007/bf02231799

Cited by 25 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Martin, the octahedral hexahydrate [Al(H 2 O) 6 ] 3+ dominates at pH < 5, and the tetrahedral [Al(OH) 4 ] − at pH > 6.2, while there is a mixture of species from 5 < pH < 6.2 [ 120 , p. 12]. Adsorption and desorption of Al 3+ species have long been known to demonstrate pH dependence [ 121 , 122 ]. The aluminum aqua ion, [Al(H 2 O) 6 ] 3+ , is well characterized in solution and the solid state [ 123 ].…”

Section: Biophysics Of Aluminum Toxicity and Impact On Cellular Prmentioning

confidence: 99%

Aluminum-Induced Entropy in Biological Systems: Implications for Neurological Disease

Shaw

Seneff

Kette

et al. 2014

Journal of Toxicology

View full text Add to dashboard Cite

Over the last 200 years, mining, smelting, and refining of aluminum (Al) in various forms have increasingly exposed living species to this naturally abundant metal. Because of its prevalence in the earth's crust, prior to its recent uses it was regarded as inert and therefore harmless. However, Al is invariably toxic to living systems and has no known beneficial role in any biological systems. Humans are increasingly exposed to Al from food, water, medicinals, vaccines, and cosmetics, as well as from industrial occupational exposure. Al disrupts biological self-ordering, energy transduction, and signaling systems, thus increasing biosemiotic entropy. Beginning with the biophysics of water, disruption progresses through the macromolecules that are crucial to living processes (DNAs, RNAs, proteoglycans, and proteins). It injures cells, circuits, and subsystems and can cause catastrophic failures ending in death. Al forms toxic complexes with other elements, such as fluorine, and interacts negatively with mercury, lead, and glyphosate. Al negatively impacts the central nervous system in all species that have been studied, including humans. Because of the global impacts of Al on water dynamics and biosemiotic systems, CNS disorders in humans are sensitive indicators of the Al toxicants to which we are being exposed.

show abstract

Section: Biophysics Of Aluminum Toxicity and Impact On Cellular Prmentioning

confidence: 99%

Aluminum-Induced Entropy in Biological Systems: Implications for Neurological Disease

Shaw

Seneff

Kette

et al. 2014

Journal of Toxicology

View full text Add to dashboard Cite

show abstract

“…Al(OH):, either alone or in combination with Mg compounds, is probably the most widely used antacid. It has been postulated that its function in the treatment of peptic ulcers lies in the ability to both neutralize acid and adsorb pepsin (707); however, evidence is strong only for the neutralization. All antacids are antipeptic in the sense that peptic activity decreases as pH increases and that pepsin is irreversibly inactivated at above pH 7.…”

Section: Medicinal Uses Of Aluminummentioning

confidence: 99%

Aluminum in the Environment and Human Health

Sorenson¹,

Campbell²,

Tepper³

et al. 1974

Environmental Health Perspectives

View full text Add to dashboard Cite

The review of over 800 references on aluminum (Al) published since the mid-fifties covers the occurrence of Al in soil, air, water, plants and food products, as well as air and water pollution problems. In addition, the existing quality criteria, the biology and toxicology of Al, and the therapeutic and medical uses are presented. It is concluded that absorption and retention or accumulation of Al in humans occurs at lower levels of intake than had been assumed formerly. However, levels of 5 to 50 times the normal daily intake do not appear to interfere with other metabolic processes. The adverse effects of Al reported in the more recent years resulted from the inhalation or ingestion of Al in concentrations many times greater than the amounts present under normal circumstances. As in the past, there is still no need for .ncern by the public or producers of Al or its products concerning hazards to human health derived from well established and extensively used products.

show abstract

“…To neutralize the formulations used in this work, a modification of the original formulation of Engley and Dey (1970) with the addition of a pepsin-adsorbing agent was developed. Examples of pepsin-adsorbing agents are aluminum hydroxide gel and charcoal (Piper and Fenton, 1961).…”

Section: Original Data -Results and Discussionmentioning

confidence: 99%

How to Assess in vitro Probiotic Viability and the Correct Use of Neutralizing Agents

et al. 2020

View full text Add to dashboard Cite

Probiotic viability is generally determined by quantifying its resistance to simulated gastric juice or to simulated intestinal fluid in in vitro tests, which measure microbial survival after given periods of contact. The use of a neutralizing agent is needed to avoid a carry-over of gastric or intestinal juice into the culture media of the subsequent analysis and to avoid any antimicrobial effect extended over the defined period of contact of the test. Neutralization of gastric juice and intestinal juice are of the utmost importance to present data accurately. Failing to do so determines a carry-over of bactericidal activity to the plates used for the enumeration, which further reduces the number of surviving cells. Examples of such incorrect adaptation of the test are available in literature. The purpose of this perspective stems from the discovery that many studies do not adhere to internationally recognized standards, e.g., EN 1040:2005 (European Committee for Standardization [ECS], 2005), to evaluate the basic, bactericidal activity of compounds, especially for the neutralization step.

show abstract

The adsorption of pepsin

Cited by 25 publications

References 9 publications

Aluminum-Induced Entropy in Biological Systems: Implications for Neurological Disease

Aluminum-Induced Entropy in Biological Systems: Implications for Neurological Disease

Aluminum in the Environment and Human Health

How to Assess in vitro Probiotic Viability and the Correct Use of Neutralizing Agents

Contact Info

Product

Resources

About