The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. sativa (Haw.) Celak

Chan, Kitman; Islam, M. W.; Kamil, Mohammad; Radhakrishnan, R.; Zakaria, Mohamed; Habibullah, Muzafar Shah; Attas, A

doi:10.1016/s0378-8741(00)00318-4

Cited by 248 publications

(158 citation statements)

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“…It has long been used as human food, animal feed, and a folk medicine in many countries as a diuretic, febrifuge, antiseptic, antispasmodic, and vermifuge agent. It exhibits a wide range of pharmacological effects, including ameliorating cognitive deficits (Wang & Yang, 2010), antibacterial (Zhang et al, 2002), hypolipidemic, antiaging, analgesic, anti-inflammatory (Chan et al, 2000), antioxidative (Dkhil et al, 2011), skeletal muscle relaxant (Parry et al, 1987(Parry et al, , 1993, wound healing (Rashed et al, 2003), and in vitro antitumor (Yoon et al, 1999) activities. It has been reported to be rich in a-linolenic acid and b-carotene (Liu et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects ofPortulaca oleraceaextract against CCl₄-induced damage in rats

Eidi

Mortazavi

Moghadam

et al. 2014

Pharmaceutical Biology

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Context: Purslane (Portulaca oleracea L., Portulacaceae) has been traditionally used in folk medicine to afford protection against liver injury, although its actual efficacy remains uncertain. Objective: To evaluate purslane as a hepatoprotective agent, we investigated the protective effect of its ethanol extract against carbon tetrachloride (CCl 4 )-induced hepatic toxicity in rats. Materials and methods: A total of 108 male Wistar rats were randomly divided into 12 groups. The first group was maintained as normal control, whereas CCl 4 (0.5 ml/kg bw, 50% CCl 4 in olive oil, i.p.), purslane extract (0.005, 0.01, 0.05, 0.1, and 0.15 g/kg bw, intragastrically), and purslane extract (five doses as above) along with CCl 4 were administered to the Groups II, III-VII, and VIII-XII, respectively. The rats were sacrificed on the 30th day, and blood was withdrawn by cardiac puncture. Liver damage was assessed by measuring hepatic marker enzymes (ALT, AST, ALP, GGT, and SOD) and histopathological observation. Results: Treatment with CCl 4 resulted in increased serum activities of marker enzymes with a concomitant decrease in SOD. Histological alterations were also observed in the liver tissue upon CCl 4 treatment. Administration of purslane extract (0.01, 0.05, 0.1, and 0.15 g/kg b.w.) significantly showed a marked tendency towards normalization of all measured biochemical parameters in CCl 4 -treated rats. Histopathological changes also paralleled the detected alteration in markers of liver function. Discussion and conclusion: These results demonstrate that purslane exerts protective effects against CCl 4 -induced damage in rat liver and supports a potential therapeutic use of purslane as an alternative for patients with liver diseases.

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Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects ofPortulaca oleraceaextract against CCl₄-induced damage in rats

Eidi

Mortazavi

Moghadam

et al. 2014

Pharmaceutical Biology

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“…Although, purslane considered as a weed in many agroecosystems, it is listed in the World Health Organization as one of the most used medicinal plants and it has been given the term ''Global Panacea'' (Samy et al 2004). The aerial parts of the plant are used medicinally for alleviating pain and swelling and as an antiseptic (Chan et al 2000). Recent research has shown that the P. oleracea is a rich source of omega-3 fatty acids, which is important in preventing heart attacks and strengthening the immune system (Simopoulos 2004).…”

Section: Introductionmentioning

confidence: 99%

Effect of salinity and silicon on root characteristics, growth, water status, proline content and ion accumulation of purslane (Portulaca oleraceaL.)

Kafi

Rahimi

2011

Soil Science and Plant Nutrition

113

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In order to study the effects of salinity and silicon application on root characteristics, growth, proline content, leaf and root ion accumulation of purslane (Portulaca oleracea L.), a greenhouse experiment was conducted at Ferdowsi University of Mashhad, Iran. The experiment was carried out in a split plot design in which levels of salinity (0, 120 and 240 mM) were allocated as main plots and silicon application of 1 mM sodium silicate and no application assigned as subplots with three replications. The results indicated that salinity caused a reduction in root growth (volume, area, diameter, total and main length and root dry weight), and shoot biomass accumulation. Both root and leaf sodium (Na) content and leaf proline content increased with increasing salinity. Leaf and root potassium (K) content decreased with increasing salinity. Application of silicon improved root area, root dry weight, and leaf and root K content in the presence of salinity. It also caused a significant reduction in leaf Na content and consequently improved the K/Na ratio in leaves. Based on these results, P. oleracea has the capacity to grow in salt stress conditions and could be considered as a medicinal and vegetable for growth in harsh environments.

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“…Reported Pharmacological Activities include wound healing, antioxidant, antifertility, antifungal, antibacterial, analgesic, anti-inflammatory, gastric-antiulcerogenic, bronchodilatory, anti hypertensive, neuropharmacological, skeletal muscle relaxant, and antitumour activities. [17][18][19][20][21][22][23][24][25][26][27][28] Therefore, with the reference to traditional and reported uses, the present study was undertaken to investigate the effect of ethanolic extract of this plant on blood glucose levels and give a scientific rational for its use.…”

Section: Introductionmentioning

confidence: 99%

Study of Ethanolic Extract of Portulaca Oleracea (Whole Plant) on Blood Glucose Levels and Body Weight in Streptozotocin Induced Diabetic Rats

Shafi¹,

Tabassum²

2018

Int. Res. J. Pharm.

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Aim:The aim of the present study was to find the effect of ethanolic extract of the whole plant of Portulaca oleracea on blood glucose levels and on body weight of streptozotocin induced diabetic rats. Methods: Rats were made diabetic by single dose of streptozotocin (50 mg/kg b.w).After checking their blood glucose levels, they were re-grouped into five groups. The 1 st group was Normal Control group,2 nd group was Diabetic Control group,3 rd group received standard drug Glibenclamide,4 th group received 50 mg.kg b.w of ethanolic extract of Portulaca oleracea and 5 th group received 100mg/kg b.w of the ethanolic extract of the plant. Their blood glucose levels and body weights were checked at regular intervals. Histopathology of pancreas of diabetic rats was also done. Results: The two doses of the ethanolic extract of the plant showed significant decrease in blood glucose levels and increase in body weights. Histopathological studies also showed significant changes. Discussion: Today diabetes mellitus is taking the form of the epidemic in many countries including India. Though conventional treatments are used to cure diabetes mellitus , but due to side effect of these drugs, there is need for alternative ways to cure the disease.Conclusion: The ethanolic extract of Portulaca oleracea has beneficial effects on blood glucose levels as well as improving other metabolic aberrations.

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The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. sativa (Haw.) Celak

Cited by 248 publications

References 10 publications

Hepatoprotective effects ofPortulaca oleraceaextract against CCl₄-induced damage in rats

Hepatoprotective effects ofPortulaca oleraceaextract against CCl₄-induced damage in rats

Effect of salinity and silicon on root characteristics, growth, water status, proline content and ion accumulation of purslane (Portulaca oleraceaL.)

Study of Ethanolic Extract of Portulaca Oleracea (Whole Plant) on Blood Glucose Levels and Body Weight in Streptozotocin Induced Diabetic Rats

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The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. sativa (Haw.) Celak

Cited by 248 publications

References 10 publications

Hepatoprotective effects ofPortulaca oleraceaextract against CCl4-induced damage in rats

Hepatoprotective effects ofPortulaca oleraceaextract against CCl4-induced damage in rats

Effect of salinity and silicon on root characteristics, growth, water status, proline content and ion accumulation of purslane (Portulaca oleraceaL.)

Study of Ethanolic Extract of Portulaca Oleracea (Whole Plant) on Blood Glucose Levels and Body Weight in Streptozotocin Induced Diabetic Rats

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Hepatoprotective effects ofPortulaca oleraceaextract against CCl₄-induced damage in rats

Hepatoprotective effects ofPortulaca oleraceaextract against CCl₄-induced damage in rats