The analgesic effect of different antidepressants combined with aspirin on thermally induced pain in Albino mice

Elhwuegi, Abdalla Salem; Hassan, Kalthom M.

doi:10.3402/ljm.v7i0.17251

Cited by 9 publications

(4 citation statements)

References 16 publications

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“…It is observed for most of the drugs used for analgesia, there is increased response with increase in dose of drugs. [20][21][22][23] Contrary to this, analgesic ceiling effect is the phenomenon that refers to the dose beyond which there is no additional analgesic effect. In a study comparing 400mg versus 600mg of ibuprofen in patients with postoperative dental pain conducted by Seymour and co-workers, showed that there is very little analgesic advantage to doses of ibuprofen above 400mg.…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent analgesic activity of mexiletine on thermally induced pain in rats

Patil¹,

Konda

2018

Int J Basic Clin Pharmacol

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Background: Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. In spite of many advances in pain research, we are unable to deal in an effective way. The cost for new drug development is increasing day by day. Drug repurposing is an approach to look for new use in drugs that are already approved for other indications. Mexiletine is a sodium channel blockers that is being approved for treatment of arrhythmias. It is being tried in treatment of various painful conditions. The present study is to evaluate the dose-dependent analgesic activity of mexiletine with ibuprofen.Methods: The analgesic activity of mexiletine was compared at doses of 15mg/kg, 30mg/kg and 45mg/kg with the standard dose of ibuprofen at 10mg/kg in male Wistar rats in thermal model of tail flick analgesiometer.Results: At lower doses (15mg/kg) of mexiletine, analgesic activity of ibuprofen was significantly higher. At higher doses (30 mg/kg and 45 mg/kg) of mexiletine, it was observed that there is no significant difference between the analgesic activities of both drugs.Conclusions: Mexiletine demonstrated a dose-dependent analgesic activity. There was no statistically significant difference between the analgesic activities of higher doses of mexiletine when compared to ibuprofen.

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Section: Discussionmentioning

confidence: 99%

Dose-dependent analgesic activity of mexiletine on thermally induced pain in rats

Patil¹,

Konda

2018

Int J Basic Clin Pharmacol

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“…Because they are both analgesic and antiinflammatory, the NSAIDs are among the most widely used of all therapeutic classes of drugs. 8 Opioids are the most potent pain-relieving drugs currently available.…”

Section: Neuropathicmentioning

confidence: 99%

“…The specific antidepressant effects are also important alleviating chronic depression is important in helping patients deal more effectively with pain. 8 In spite of having a number of drugs for the management of pain, there is still need for an ideal analgesic agent with favorable safety profile.…”

Section: Neuropathicmentioning

confidence: 99%

Study of antinociceptive effect of paroxetine in acute pain in albino rats

Byndoor¹,

Nausheen²,

Patil³

2016

Int J Basic Clin Pharmacol

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Background: Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. In spite of having a number of drugs like NSAIDS and opioids for the management of pain, there is still need for an ideal analgesic agent with favourable safety profile. Many studies have shown that antidepressant drugs also have analgesic activity and particularly, selective serotonin reuptake inhibitors (SSRI) are effective in mixed and chronic pain. This study was done to evaluate antinociceptive effect of Paroxetine in albino rat and to compare antinociceptive effect of Paroxetine with the standard drug pentazocine in albino rat. Methods: Animals were divided into five groups of six each, group I as control, group II as standard whereas groups III, IV and V as test groups (three doses). Antinociceptive effect of group II pentazocine (10 mg/kg intraperitoneal) and group III, IV and V received paroxetine (2.5 mg/kg, 5 mg/kg, and 10 mg/kg bodyweight intraperitoneally respectively) was evaluated in adult albino rats by Tail flick method. Results: Mean RT after 120 minutes of injection of Paroxetine (10 mg) was higher than baseline value of 3.42 second with, mean difference 9.55±0.45 and is significant when compared to control. No significant difference in RT was found between paroxetine 10 mg and pentazocine 10 mg. No significant difference found when baseline reading was compared with 120 minutes readings of paroxetine 2.5 group. Conclusions: Paroxetine, a SSRI antidepressant, has a clear antinociceptive activity.

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“…8 Rheumatoid arthritis, osteoarthritis and musculoskeletal injuries are widely treated with non-steroidal anti-inflammatory drugs.…”

Section: Introductionmentioning

confidence: 99%

Non-Steroidal Anti-Inflammatory Drugs; Comparative Analysis

Zaidi¹,

Turab²,

Qasim³

et al. 2016

TPMJ

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Subjects and Methods: This is a comparative study of analgesic efficacy between aspirin, diclofenac and ketorolac. 40 albino rats were taken and divided into 4 equal groups. Group A, B, C and D treated with normal saline, Aspirin, diclofenac and ketorolac respectively. Results: Significant increase in reaction time was observed with aspirin, diclofenac and ketorolac (p<0.001) using hotplate analgesia meter. Increase in tail flick latency was also found with all three drugs. Ketorolac produces 6.7 second increase in tail flick latency. Conclusion: NSAIDs are the first line of management in acute and chronic pain. Ketorolac is more effective than other nonsteroidal anti-inflammatory drugs. Key words:NSAIDs, Aspirin, Diclofenac, Ketorolac

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The analgesic effect of different antidepressants combined with aspirin on thermally induced pain in Albino mice

Cited by 9 publications

References 16 publications

Dose-dependent analgesic activity of mexiletine on thermally induced pain in rats

Dose-dependent analgesic activity of mexiletine on thermally induced pain in rats

Study of antinociceptive effect of paroxetine in acute pain in albino rats

Non-Steroidal Anti-Inflammatory Drugs; Comparative Analysis

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