2021
DOI: 10.1038/s41591-020-01168-7
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The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer

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Cited by 169 publications
(185 citation statements)
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“…The present study indicated that high LAT1 expression was an independent poor prognostic factor in luminal B-like BCa. Androgen receptor (AR) signaling pathway plays an important role in BCa progression (Iacopetta D et al 2012;Hickey TE et al 2021). We have revealed that AR protein expression was highly expressed in approximately 55% of invasive BCa (Aleskandarany MA et al 2016), and AR signaling pathway was related to treatment resistance and prognosis of BCa (Kurozumi S et al 2019c).…”
Section: Discussionmentioning
confidence: 99%
“…The present study indicated that high LAT1 expression was an independent poor prognostic factor in luminal B-like BCa. Androgen receptor (AR) signaling pathway plays an important role in BCa progression (Iacopetta D et al 2012;Hickey TE et al 2021). We have revealed that AR protein expression was highly expressed in approximately 55% of invasive BCa (Aleskandarany MA et al 2016), and AR signaling pathway was related to treatment resistance and prognosis of BCa (Kurozumi S et al 2019c).…”
Section: Discussionmentioning
confidence: 99%
“…As AR agonists advance as a possible treatment strategy in ER-positive, AR-positive breast cancer, AR antagonists are also being pursued 7,8 , a continuation of the apparent enigma that steroid hormones can both drive tumor progression and inhibit it. Indeed, while it is clear, and further established in the work by Hickey et al 1 , that AR positivity in breast cancer confers a better prognosis 4,5 , ER positivity does as well, and the antagonism of ER has been one of the greatest successes in the treatment of breast cancer. Pre-clinical studies of the use of AR agonists and antagonists in models of breast cancer have produced conflicting results, at least in part because of variability in the growth media, which may substantially modulate the role of AR signaling in breast cancer 9 .…”
mentioning
confidence: 98%
“…he progression of breast cancer has long been known to be influenced by steroid hormones and their receptors, including both the estrogen receptor (ER) and the androgen receptor (AR). In this issue of Nature Medicine, Hickey et al take important steps toward elucidating the role of the AR pathway in breast cancer by performing comprehensive transcriptomic and chromatin profiling of multiple models of ER-positive breast cancer and find that AR is a promising target as a therapy for breast cancer 1 (Fig. 1).…”
mentioning
confidence: 99%
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