The anti diabetic and anti obesity effect of Memecylon umbellatum extract in high fat diet induced obese mice

Sunil, Vasanthi R.; Shree, Nitya; Venkataranganna, Marikunte V; Bhonde, Ramesh; Majumdar, Mala

doi:10.1016/j.biopha.2017.01.182

Cited by 25 publications

(16 citation statements)

References 19 publications

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“…Recent studies suggested that terpenes or phenolic compounds of the plant organ reduced the fatty infiltration in the liver as well as they decreased the size of adipocytes in adipose tissues of HFD obese rats . These studies confirm our results suggesting that terpenes including phytol and phenolic compounds of C. olitorius extract are responsible for the hepatoprotective and anti‐adipogenic effects shown by C .…”

Section: Discussionsupporting

confidence: 91%

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Gomaa

Elsers

Al-Zokeim

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives To determine the efficacy of Corchorus olitorius (C. olitorius) leaf extract in the prevention of metabolic syndrome induced in rats by high‐fat diet (HFD) and compare it with that of orlistat. Methods Phytochemical analysis was performed. Effect of orlistat and C. olitorius extract on lipase activity and acute food intake were investigated. Body weight, biochemical parameters and histopathological examination were demonstrated. Key findings Corchorus olitorius extract inhibited the pancreatic lipase activity, but orlistat was more potent. Cumulative food intake has not changed by the tested agents. In obese rats, C. olitorius or orlistat significantly decreased weight gain and visceral white adipose tissue. They exhibited a significant reduction in serum glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol, free fatty acids, IL‐1β, tumour necrosis factor‐α (TNF‐α), insulin and leptin levels of obese rat groups while high density lipoprotein cholesterol and adiponectin levels were significantly increased by them. Histopathological examination of the liver revealed that C. olitorius was more effective than orlistat in the alleviating of steatosis and adipocyte hypertrophy shown in obese control rats. Conclusions Corchorus olitorius is effective as orlistat in preventing obesity, hyperlipidaemia, steatosis and insulin resistance. These actions may be mediated by inhibiting of lipase activity, TNF‐α, IL‐1β and leptin resistance along with increasing of adiponectin.

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Section: Discussionsupporting

confidence: 91%

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Gomaa

Elsers

Al-Zokeim

et al. 2019

Journal of Pharmacy and Pharmacology

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“…Oxidative modification of LDL plays an immense role in the initial development of atherosclerosis and promotes further accumulation of free radicals in the arterial wall. A significant increase of aortic oxLDL and MDA levels in the HFD group might suggest an excessive formation of oxidative stress in the aortic tissue following HFD ingestion as a consequence of the lipid oxidation process [34]. Meanwhile, these oxidative stress markers demonstrated significantly lower levels in the HFD + BB group compared to the HFD group.…”

Section: Discussionmentioning

confidence: 92%

Phenolic Compounds and the Anti-Atherogenic Effect of Bee Bread in High-Fat Diet-Induced Obese Rats

et al. 2019

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This study was undertaken to determine the phenolic compounds and the anti-atherogenic effect of bee bread in high-fat diet (HFD)-induced obese rats. The presence of phenolic compounds in bee bread was determined by liquid chromatography–mass spectrometry. Thirty-two male Sprague Dawley rats were divided into four groups, (n = 8/group); i.e., Normal (N), HFD (high-fat diet), HFD + BB (high-fat diet and 0.5 g/kg/day bee bread), and HFD + O (high-fat diet and 10 mg/kg/day orlistat) groups. After 6 weeks of the experiment, rats were sacrificed. Five phenolic compounds were identified in bee bread; namely, caffeic acid, ferulic acid, kaempferol, apigenin, and isorhamnetin. Bee bread significantly reduced Lee obesity index and levels of total cholesterol (TC), low-density lipoprotein (LDL), fatty acid synthase (FAS) activity, atherogenic index, oxidised-LDL (oxLDL), and malondialdehyde (MDA), and significantly increased aortic antioxidant activities, such as those of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Adipocyte sizes were found to be smaller in the HFD + BB group compared to the N group, and en face aortas showed an absence of atherosclerotic plaque in rats supplemented with bee bread. These changes might suggest an anti-atherogenic effect of bee bread in HFD-induced obese rats via its antioxidant and hypocholesterolaemic properties.

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“…Abnormalities like obesity can make people more prone to various disorders like cardiovascular disorder, diabetes. 2,22 Diet, nutrition and exercise play a key role in prevention and treatment of metabolic diseases. Research show that herbal extracts have a significant role in amelioration of the metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…The increased shift in these haematological and body parameters can cause serious damage to body cells leading to organ failures. [22][23] High fat containing items are mostly used diet in today's population. Its regular and high intake will be the cause of many diseases in coming era, hence its balance is one of the major concern.…”

Section: Discussionmentioning

confidence: 99%

Amelioration of Metabolic Syndrome in High Fat Fed Mice by Hydro-Ethanolic Fraction of M. longifolia (J. Koenig)

Jha¹,

Mazumder²

2019

IJPER

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Objective: To investigate the effect of hydro-ethanolic fraction of leaves of M. longifolia (J. Koenig) on high fat diet induced metabolic disorder. Methods: The M. longifolia extract was obtained from the successive extraction followed by fractionation. Ex vivo glucose uptake study was performed. Body weight and blood glucose was checked at regular intervals. After euthanasia serum biochemical parameters, lipid parameters were estimated. Organs were isolated, weighed and fixed in formalin for histopathological analysis. Results: Compared to control, M. longifolia leaf fractions showed significant glucose uptake inhibition in ex vivo studies (rat hemi diaphragm and rat intestinal glucose uptake assay). HFD group showed significant weight increase as compared to normal control. Blood glucose level and glycosylated haemoglobin was found elevated in disease group (obesity and diabetic group). Significant increase in lipid profile of disease group aggravates the diabetic condition. Animal treated with M. longifolia leaf fractions (400mg/kg) helps in normalisation of liver and white adipose tissue. Conclusion: Metabolic syndrome is an agglomeration of disorders inclusive of increased blood glucose, excess body fat, anomalous triglyceride and cholesterol level, which on joint occurrence leads to diabetes and increased risk of heart disease. Our data suggest that treatment with M. longifolia to HFD + STZ group alleviates the diabetes and helps in control of obesity. It may be due to presence of various bioactive constituents.

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The anti diabetic and anti obesity effect of Memecylon umbellatum extract in high fat diet induced obese mice

Cited by 25 publications

References 19 publications

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Phenolic Compounds and the Anti-Atherogenic Effect of Bee Bread in High-Fat Diet-Induced Obese Rats

Amelioration of Metabolic Syndrome in High Fat Fed Mice by Hydro-Ethanolic Fraction of M. longifolia (J. Koenig)

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