The Anti-Inflammatory Effect and Intestinal Barrier Protection of HU210 Differentially Depend on TLR4 Signaling in Dextran Sulfate Sodium-Induced Murine Colitis

Lin, Sisi; Li, Yongyu; Shen, Li; Zhang, Ruiqin; Yang, Lizhi; Li, Min; Li, Kun; Fichna, Jakub

doi:10.1007/s10620-016-4404-y

Cited by 25 publications

(16 citation statements)

References 62 publications

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“…The role of TLR4‐related signaling in GB varies according to the specific conditions. In a previous study, we found that TLR4 deficiency improved GB function in colitis . Moreover, Dheer et al .…”

Section: Introductionmentioning

confidence: 66%

Alterations in the gut barrier and involvement of Toll‐like receptor 4 in murine postoperative ileus

Lin

Zhang

Shen

et al. 2018

Neurogastroenterology Motil

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Section: Introductionmentioning

confidence: 66%

Alterations in the gut barrier and involvement of Toll‐like receptor 4 in murine postoperative ileus

Lin

Zhang

Shen

et al. 2018

Neurogastroenterology Motil

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“…These results are in agreement with a previous study using a similar DSS treatment protocol in WT and Tlr4 −/− mice (24). Some previous studies showed that, compared to WT mice, Tlr4 −/− mice had attenuated DSS-induced colitis (25–27), or enhanced colitis (28). These inconsistent results could be in part due to differences in treatment conditions or in mouse strains.…”

Section: Discussionmentioning

confidence: 99%

A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice

et al. 2018

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Triclosan (TCS) is a high-volume chemical used as an antimicrobial ingredient in more than 2000 consumer products, such as toothpaste, cosmetics, kitchenware, and toys. We report that brief exposure to TCS, at relatively low doses, causes low-grade colonic inflammation, increases colitis, and exacerbates colitis-associated colon cancer in mice. Exposure to TCS alters gut microbiota in mice, and its proinflammatory effect is attenuated in germ-free mice. In addition, TCS treatment increases activation of Toll-like receptor 4 (TLR4) signaling in vivo and fails to promote colitis in mice. Together, our results demonstrate that this widely used antimicrobial ingredient could have adverse effects on colonic inflammation and associated colon tumorigenesis through modulation of the gut microbiota and TLR4 signaling. Together, these results highlight the need to reassess the effects of TCS on human health and potentially update policies regulating the use of this widely used antimicrobial.

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“…POI increases the risk of postoperative complications and morbidity [ 3 ]. Recent studies have shown that postoperative inflammatory reactions are involved in the development of POI [ 10 , 13 , 14 ]. Consistently, with earlier reports [ 6 , 7 ] at 24 h and 48 h after intestinal manipulation, we observed a significant decrease in the GI transit rate and induction of an inflammatory response characterized by leukocyte infiltration in the intestinal tissue, villous epithelial cell structural damage, submucosal edema, hyperemia, and epithelial cell necrosis.…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medicine Da‐Cheng‐Qi‐Tang Ameliorates Impaired Gastrointestinal Motility and Intestinal Inflammatory Response in a Mouse Model of Postoperative Ileus

Chen

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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This study was to explore the therapeutic effect and mechanism of the traditional Chinese medicine with the formula Da-Cheng-Qi-Tang (T-DCQT) and a modified Da-Cheng-Qi-Tang (M-DCQT) in a postoperative ileus (POI) mouse model. POI was induced via small bowel manipulation, and T-DCQT or M-DCQT was given by enema. The intestinal motility was measured with a charcoal mixture gavage. The intestinal tissues were collected for further studies by histopathological, qPCR, immunohistochemical staining, and Western blotting. Levels of inflammatory cytokines in blood were determined using a high-throughput liquid chip. We found that gastrointestinal dysfunction was alleviated after administration of either a T-DCQT or M-DCQT enema. Increased expression of NF-κB, p38 MAPK, and TLR4 in the intestinal tissues of POI mice were reversed following treatment. IL-1α, IL-6, MIP-1β, and IL-17 levels were significantly reduced at 24 h and 48 h following treatment, while the MCP-1 level was only observed to be reduced at 24 h after the treatment. Furthermore, compared with the T-DCQT effect, M-DCQT treatment was more effective in alleviating the increased IL-6, MIP-1β, and IL-1α levels. So, we draw a conclusion that T-DCQT or M-DCOT could ameliorate the POI-associated inflammatory response and improve GI motility in a POI mouse model.

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The Anti-Inflammatory Effect and Intestinal Barrier Protection of HU210 Differentially Depend on TLR4 Signaling in Dextran Sulfate Sodium-Induced Murine Colitis

Cited by 25 publications

References 62 publications

Alterations in the gut barrier and involvement of Toll‐like receptor 4 in murine postoperative ileus

Alterations in the gut barrier and involvement of Toll‐like receptor 4 in murine postoperative ileus

A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice

Traditional Chinese Medicine Da‐Cheng‐Qi‐Tang Ameliorates Impaired Gastrointestinal Motility and Intestinal Inflammatory Response in a Mouse Model of Postoperative Ileus

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