The Antibacterial Activities of Durian Rinds Extract (Durio Zibethinus) Against Propionibacterium acne

Abstract

Acne vulgaris is a kind of skin diseases which caused by Propionibacterium acne bacterias. Nowadays, the treatments of acne are still using the antibiotics as a first protocol, but the overuses of this in a long duration can be resistants. Therefore, it is very important to find some candidates of natural products to become antibacterial agents in the acne treatments. One of the natural products is Durian (Durio zibethinus (Linn)), a part of durian which is called rinds of durian known as mesocarpium, it contains a lot of organic chemical compounds, there are alkaloids, saponins, flavonoids, tannins, and phenolics which have antibacterial activities especially in flavonoids. This study was aimed to determine the antibacterial activity of durian rinds extracts to the Propionibacterium acnes bacterias. This study was used as a randomized completed trial design. The test of antibacterial activities uses the dilution method in 96 well plate and diffusion method, then the amount of the colony was measured by colony counter. The treatments were using a series concentrations 2.5%, 5%, 7.5%, and 10%, the negative control using 10% of DMSO and the positive control using clindamycine. The Results showed that the rinds of durian have given the moderates antibacterial activities at the 7.5% concentrations with the MIC value of 5% and the colony number was 67 colonies. Based on this results, it might conclude that the rinds of durian have the potential as an antibacterial agent which was bacteriostatic.

Antibacterial Potential of Durian (Durio zibethinus murr.) Waste as an Alternative Disinfectant in Raw Drinking Water - A Literature Review

“…49 Of the 17 studies that made antimicrobial observations as shown in table 2, there were 14 studies that made observations using the diffusion method. Research conducted by Fitrianingsih F, et al (2019), 18 found the bacterial inhibitory value of 5% durian skin extract to be 5 to 10 mm. This value is a relatively strong inhibitory value, so it can be said that durian peel extract is very likely to be used as an antimicrobial agent.…”

Acute Toxicity Study of Durian Mesocarpium Ethanol Extracts (Durio Zibethinus Linn) in Healthy Mice

“…It has been used alternatively as traditional medicines. The previous study reported that Durian has some activities like antibacterial [4] anti-inflammation [5][6] antioxidant [5][6] anti hyperuricemia [7] [16]. However, there are limited studies have been reported about toxicity of its bioactive compounds.…”