The Anticancer Potential of Pavonia odorata extract on Human Breast (MD-MB-231), Prostate (PC-3) and Lung (Calu-6) Cancer cell lines

Girish, H. V.; Vinod, Arya; Dhananjaya, Bhadrapura Lakkappa; D, Satish Kumar; Duraisamy, Senthil

doi:10.5530/pj.2016.1.6

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…6 Many plants in this Amaranthaceae have been used in folk medicine for treatment of several diseases, such as diabetes, coughs, body aches, asthma, arterial hypertension, jaundice, dysmenorrhea, and certain infectious diseases. 7,8 The Gomphrena genus has been reported to contain alkaloids, saponins, ketoses, ecdysteroids, amino acids, terpenoids, flavonoids, hydrocarbons, alcohols, betacyanins, and steroids. 6,8,9 Gomphrena celosioides is an herbaceous perennial belonging to the family Amaranthaceae, Gromthrena genus.…”

Section: Introductionmentioning

confidence: 99%

“…7,8 The Gomphrena genus has been reported to contain alkaloids, saponins, ketoses, ecdysteroids, amino acids, terpenoids, flavonoids, hydrocarbons, alcohols, betacyanins, and steroids. 6,8,9 Gomphrena celosioides is an herbaceous perennial belonging to the family Amaranthaceae, Gromthrena genus. In Vietnam, it has been used as a traditional medicine to treat respiratory and gout diseases.…”

Section: Introductionmentioning

confidence: 99%

“…The Gomphrena genus belongs to the Amaranthaceae family, which consists of about 120 species distributed in South America, Asia, and Vietnam 6 . Many plants in this Amaranthaceae have been used in folk medicine for treatment of several diseases, such as diabetes, coughs, body aches, asthma, arterial hypertension, jaundice, dysmenorrhea, and certain infectious diseases 7,8 …”

Section: Introductionmentioning

confidence: 99%

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Xanthine oxidase and nitric oxide inhibitory activities of compounds isolated from Gomphrena celosioides

Quang,

Phuong,

Luong

et al. 2024

Vietnam Journal of Chemistry

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In this study, the investigation of xanthine oxidase and nitric oxide formation inhibitory activities of three compounds isolated from aerial part of Gomphrena celosioides, a folk medicinal plant for treatment of gout disease, is reported. The isolated compounds were determined based on NMR and ESI‐MS spectra, they are umbellatosides B, 20‐hydroxyecdysone, and 20‐hydroxyecdysone‐20,22‐monoacetonide. Biological activity results indicated that three compounds showed great activities, in which, umbellatosides B has good activity with IC50 value of 33.78 ± 0.49 and 19.55 ± 0.61 µm for xanthine oxidase and nitric oxide inhibitory activities, respectively. This is the report on the xanthine oxidase and nitric oxide inhibitory activities of three compounds that were first time isolated from the G. celosioides.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Xanthine oxidase and nitric oxide inhibitory activities of compounds isolated from Gomphrena celosioides

Quang,

Phuong,

Luong

et al. 2024

Vietnam Journal of Chemistry

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Family Malvaceae: a potential source of secondary metabolites with chemopreventive and anticancer activities supported with in silico pharmacokinetic and pharmacodynamic profiles

Sameh,

Elissawy,

Al-Sayed

et al. 2024

Front. Pharmacol.

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IntroductionCancer is the second most widespread cause of mortality following cardiovascular disorders, and it imposes a heavy global burden. Nowadays, herbal nutraceutical products with a plethora of bioactive metabolites represent a foundation stone for the development of promising chemopreventive and anticancer agents. Certain members of the family Malvaceae have traditionally been employed to relieve tumors. The literature concerning the chemopreventive and anticancer effects of the plant species along with the isolated cytotoxic phytometabolites was reviewed. Based on the findings, comprehensive computational modelling studies were performed to explore the pharmacokinetic and pharmacodynamic profiles of the reported cytotoxic metabolites to present basis for future plant-based anticancer drug discovery.MethodsAll the available information about the anticancer research in family Malvaceae and its cytotoxic phytometabolites were retrieved from official sources. Extensive search was carried out using the keywords Malvaceae, cancer, cytotoxicity, mechanism and signalling pathway. Pharmacokinetic study was performed on the cytotoxic metabolites using SWISS ADME model. Acute oral toxicity expressed as median lethal dose (LD50) was predicted using Pro Tox 3.0 web tool. The compounds were docked using AutoDock Vina platform against epidermal growth factor receptor (EGFR kinase enzyme) obtained from the Protein Data Bank. Molecular dynamic simulations and MMGBSA calculations were performed using GROMACS 2024.2 and gmx_MMPBSA tool v1.5.2.ResultsOne hundred forty-five articles were eligible in the study. Several tested compounds showed safe pharmacokinetic properties. Also, the molecular docking study showed that the bioactive metabolites possessed agreeable binding affinities to EGFR kinase enzyme. Tiliroside (25), boehmenan (30), boehmenan H (31), and isoquercetin (22) elicited the highest binding affinity toward the enzyme with a score of −10.4, −10.4, −10.2 and −10.1 Kcal/mol compared to the reference drug erlotinib having a binding score equal to −9 Kcal/mol. Additionally, compounds 25 and 31 elicited binding free energies equal to −42.17 and −42.68 Kcal/mol, respectively, comparable to erlotinib.DiscussionOverall, the current study presents helpful insights into the pharmacokinetic and pharmacodynamic properties of the reported cytotoxic metabolites belonging to family Malvaceae members. The molecular docking and dynamic simulations results intensify the roles of secondary metabolites from medicinal plants in fighting cancer.

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The Anticancer Potential of Pavonia odorata extract on Human Breast (MD-MB-231), Prostate (PC-3) and Lung (Calu-6) Cancer cell lines

Cited by 2 publications

References 6 publications

Xanthine oxidase and nitric oxide inhibitory activities of compounds isolated from Gomphrena celosioides

Xanthine oxidase and nitric oxide inhibitory activities of compounds isolated from Gomphrena celosioides

Family Malvaceae: a potential source of secondary metabolites with chemopreventive and anticancer activities supported with in silico pharmacokinetic and pharmacodynamic profiles

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