The Anticancer Properties of Artemisia aucheri Boiss Extract on HT29 Colon Cancer Cells

Ali, Alaa; Saeed, Noor Al-Huda Ali A.H.; Omear, Hadeel Abdulhadi

doi:10.1007/s12029-019-00354-2

Cited by 11 publications

(5 citation statements)

References 23 publications

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“…Similar findings were reported by Kokhdan et al (2018). The observations of the present study are in conformity with the reports of Sangeetha et al (2019), Ali et al (2020) and Suhas et al (2021).…”

Section: Discussionsupporting

confidence: 94%

Evaluation of Anti-Colorectal Cancer Activity in Methanolic Extract of Coleus forskohlii Root

P¹,

Malarvizhi²

2022

IJZI

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In a multistage process that involves moving from a precancerous lesion to a malignant tumour state, cancer develops when normal cells undergo the change into tumour cells. Colon cancer, also known as colorectal cancer (CRC), is the third most common and second-deadliest malignant tumour in the world. The current study's objective was to assess the anticancer potential of a methanolic extract of Coleus forskohlii root on the cancer cell line HT-29 using the MTT assay. A variety of assay methods were used, including morphological investigations, cell growth inhibition, and cell viability. At various concentrations (12.5, 25, 50, 100, and 200 µg/ml), the Coleus forskohlii extract was tested against the HT-29 cell line for its ability to inhibit cell proliferation. This study revealed that when concentrations rise the cell growth inhibition levels rise. The conventional medicine Doxorubicin had a growth inhibition of 72.70% at a dose of 5 µg/ml while the lowest growth inhibition was determined to be 9.55% at 12.5 µg/ml and the highest growth inhibition was 71.16% at 200 µg/ml. IC50 was greater than 123.90 µg/ml. According to the study's findings, a human colon adenocarcinoma cell line could be resistant to the anti-colorectal cancer effects of Coleus forskohlii root methanolic extract (HT-29).

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Section: Discussionsupporting

confidence: 94%

Evaluation of Anti-Colorectal Cancer Activity in Methanolic Extract of Coleus forskohlii Root

P¹,

Malarvizhi²

2022

IJZI

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“…In comparison, the standard cyclophosphamide was more toxic to these cells, with respective IC 50 values of 3.12 ± 0.13, 5.74 ± 0.20, and 6.04 ± 0.21 µg/mL. Previous studies have also shown different species of Artemisia in various cancer cells [ 47 , 48 , 49 , 50 ]. In addition, the green synthesized nanoparticles from different Artemisia species are also reported to exert antiproliferative effects on cancer cells mediated through apoptotic cell death [ 23 , 51 , 52 ].…”

Section: Resultsmentioning

confidence: 86%

Phytochemical Composition and In Vitro Antioxidant, Anti-Inflammatory, Anticancer, and Enzyme-Inhibitory Activities of Artemisia nilagirica (C.B. Clarke) Pamp

Albaqami

Benny²,

Hamdi

et al. 2022

Molecules

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Plants have been employed in therapeutic applications against various infectious and chronic diseases from ancient times. Various traditional medicines and folk systems have utilized numerous plants and plant products, which act as sources of drug candidates for modern medicine. Artemisia is a genus of the Asteraceae family with more than 500 species; however, many of these species are less explored for their biological efficacy, and several others are lacking scientific explanations for their uses. Artemisia nilagirica is a plant that is widely found in the Western Ghats, Kerala, India and is a prominent member of the genus. In the current study, the phytochemical composition and the antioxidant, enzyme-inhibitory, anti-inflammatory, and anticancer activities were examined. The results indicated that the ethanol extract of A. nilagirica indicated in vitro DPPH scavenging (23.12 ± 1.28 µg/mL), ABTS scavenging (27.44 ± 1.88 µg/mL), H2O2 scavenging (12.92 ± 1.05 µg/mL), and FRAP (5.42 ± 0.19 µg/mL). The anti-inflammatory effect was also noticed in the Raw 264.7 macrophages, where pretreatment with the extract reduced the LPS-stimulated production of cytokines (p < 0.05). A. nilagirica was also efficient in inhibiting the activities of α-amylase (38.42 ± 2.71 µg/mL), α-glucosidase (55.31 ± 2.16 µg/mL), aldose reductase (17.42 ± 0.87 µg/mL), and sorbitol dehydrogenase (29.57 ± 1.46 µg/mL). It also induced significant inhibition of proliferation in breast (MCF7 IC50 = 41.79 ± 1.07, MDAMB231 IC50 = 55.37 ± 2.11µg/mL) and colon (49.57 ± 1.46 µg/mL) cancer cells. The results of the phytochemical screening indicated a higher level of polyphenols and flavonoids in the extract and the LCMS analysis revealed the presence of various bioactive constituents including artemisinin.

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“… •The extract significantly induced apoptosis and inhibited the migration of cells. [ 6 ] 20 Calligonum comosum (L’Her) Methanol fruit hairs extract (MFH) •Antiproliferation •Induces apoptosis An in vitro study using human hepatocarcinoma cells (HepG2) •MFH exerted potent antiproliferation activity with IC50 of 10.4 mg/ml. •MFH induced overexpression of mRNA transcript levels of gen p53, caspase-3, and Bax as pro-apoptotic.…”

Section: Introductionmentioning

confidence: 99%

Natural products targeting inflammation-related metabolic disorders: A comprehensive review

Nainu

Frediansyah²,

Mamada

et al. 2023

Heliyon

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The Anticancer Properties of Artemisia aucheri Boiss Extract on HT29 Colon Cancer Cells

Cited by 11 publications

References 23 publications

Evaluation of Anti-Colorectal Cancer Activity in Methanolic Extract of Coleus forskohlii Root

Evaluation of Anti-Colorectal Cancer Activity in Methanolic Extract of Coleus forskohlii Root

Phytochemical Composition and In Vitro Antioxidant, Anti-Inflammatory, Anticancer, and Enzyme-Inhibitory Activities of Artemisia nilagirica (C.B. Clarke) Pamp

Natural products targeting inflammation-related metabolic disorders: A comprehensive review

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