The antinociceptive effect of some Egyptian medicinal plant extracts

Atta, Attia H.; Abo‐EL‐Sooud, Khaled

doi:10.1016/j.jep.2004.07.006

Cited by 81 publications

(46 citation statements)

References 12 publications

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“…daily for 5 days and kept as normal control. Rats of the second group were given the same dose of corn oil, in addition CCl 4 (50% in corn oil) was given in a single oral dose of 2.5 ml kg -1 b.wt. two hours after the last dose of the oil.…”

Section: Hepatoprotective Effectmentioning

confidence: 99%

Potential protective effect of some plant extracts against carbon tetrachloride – induced hepatotoxicity

Atta¹,

Nasr²,

Mouneir³

2006

Afr. J. Trad. Compl. Alt. Med.

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Plantago major seeds, Diplotaxis acris and Schouiwa thebaica methanol extracts were evaluated for their potential hepatoprotective effects against carbon tetrachloride induced hepatic damage model. Preliminary phytochemical studies were carried out to elucidate their components. Oral administration of the methanol extract (1000 mg kg -1 ) of Plantago major seeds, Diplotaxis acris and Schouiwa thebaica significantly (P< 0.05) attenuated the CCl 4 -induced hepatotoxicity. This was indicated by the tendency of serum enzyme activities to return toward the normal values. Moreover the histopathological changes of liver tissues induced by CCl 4 were moderate to mild in methanol extractpretreated rats. No toxic symptoms were reported in rats receiving methanol extract at doses up to 2.5 g kg -1 . Unsaturated sterols and/or triterpenes, tannins, flavonoids and carbohydrates and/or glycosides were the major active constituents of the tested plants.

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Section: Hepatoprotective Effectmentioning

confidence: 99%

Potential protective effect of some plant extracts against carbon tetrachloride – induced hepatotoxicity

Atta¹,

Nasr²,

Mouneir³

2006

Afr. J. Trad. Compl. Alt. Med.

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“…For some of these herbs, their pharmacological effects are explained in detail, such as Ficuscarica (15), Rosa damascenna (16), and Viola odorata (17); some have been used as a laxative in folklore medicine or other traditional medicine, such as those of the Greeks, Romans, and Egyptians, including Alhagi mannifera (18), Linnium usitatissimum (19), and Malva sylvestris (20). Some of these plants are mentioned as a laxative in different articles, such as Aloe species (21), Cassia angustifolia (22), Cassia fistula (23), Cordia myxa (24), Olea europaea (25), Plantago ovate (26), and Prunus domestica (27).…”

Section: Discussionmentioning

confidence: 99%

Constipation and Laxative Herbs in Iranian Traditional Medicine

Masoomi

Feyzabadi

Hamedi

et al. 2016

Iran Red Crescent Med J

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Context: Constipation is one of the most prevalent gastrointestinal disorders and is characterized by stiffness of waste and difficult defecation. In modern medicine, different laxative drugs are used for the treatment of constipation, but they are not without side effects. Nonetheless, the appropriate use of herbal medicines can be beneficial for treating this disorder. Therefore, this study attempted to draw together some pharmacological and medical insights into the management of constipation through the use of Iranian traditional medicine (ITM). Evidence Acquisition: In this review article, we initially researched constipation and laxative herbs using some of the most famous ancient medical and pharmacological textbooks pertaining to Iranian medicine written from the 10 th to 18 th century AD. This includes The canon of medicine by Avicenna (10 th and 11 th centuries, Beirut publication), Makhzan-ol-advie by Aghili (18 th century, Tehran University of Medical Science Press), and Al-shamel by Gharashi (13 th century, Caltural foundation Publication). Then we extracted the names and laxative mechanisms of some herbs prescribed for constipation through ITM. Finally, a search of scientific databases such as PubMed and Google Scholar was performed to find related works concerning laxative mechanisms. Results: In ITM doctrine, laxatives are weak purgatives that lead to the defecation of waste from the gastrointestinal tract. From this perspective, laxative herbs can be classified into two groups based on their nature: laxative herbs with a hot nature cause the dilution and flowing of humors, but herbs with a cold nature function as laxatives due to their mucilage properties. Each of the laxatives was used in accordance with the primary reason for constipation. Conclusions:This study presents medical and pharmacological approaches in ITM for dealing with complications arising from constipation. Considering the optimistic results, these herbs can be used as a means of constipation management and further investigation into this area can potentially lead to the formulation of new drugs.

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“…ex Hiern) stem bark induces considerable dose-dependent analgesic effects against the writhing syndrome observed in the acetic acid test. These abdominal writhes, which result from the action of severe visceral pain [10], are probably suppressed mostly by a peripheral analgesic effect of the remedies tested [11][12][13]. In peripheral tissues, the development of pain is mostly a consequence of sensitization of the chemosensitive nociceptors by prostaglandins [14].…”

Section: Discussionmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Effects of an Extract of Fadogia agrestis in Rats

Oyekunle

Okojie

2010

Neurophysiology

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Analgesic and anti-inflammatory activities of an aqueous extract produced from Fadogia agrestis (family Rubiaceae) stem bark were investigated using animal models. Significant dose-dependent increases in the reaction time in the tail-flick test and inhibition of writhing in the visceral pain test (i.p. injections of acetic acid) with P up to < 0.001, when compared with the control, were observed. In an anti-inflammatory investigation, we also found significant dose-dependent inhibitions in the carrageenan-induced paw edema and cotton-pellet granuloma tests. The extract in the highest non-sedative dose tested (200 mg/kg) demonstrated a potency comparable with that of a reference analgesic anti-inflammatory drug, acetyl salicylate (Aspirin, 100 mg/kg). Phytochemical screening revealed the presence of alkaloids and saponins in the extract. The relieving effects of Fadogia are probably mediated by the influences of active components of the extract on both central and peripheral nociceptive/ antinociceptive neural mechanisms. Therefore, our investigation explains the rationale behind the ethnomedicinal usage of the mentioned plant to relieve pain and inflammation, as claimed by local users, and shows that further studies of the mechanisms underlying the effects of the remedy tested are expedient.

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The antinociceptive effect of some Egyptian medicinal plant extracts

Cited by 81 publications

References 12 publications

Potential protective effect of some plant extracts against carbon tetrachloride – induced hepatotoxicity

Potential protective effect of some plant extracts against carbon tetrachloride – induced hepatotoxicity

Constipation and Laxative Herbs in Iranian Traditional Medicine

Analgesic and Anti-Inflammatory Effects of an Extract of Fadogia agrestis in Rats

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