Potential protective effect of some plant extracts against carbon tetrachloride – induced hepatotoxicity

Atta, Attia H.; Nasr, Soad M.; Mouneir, Samar M.

doi:10.4314/ajtcam.v3i3.31162

Cited by 16 publications

(15 citation statements)

References 25 publications

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“…It is concluded that the lowest concentration exhibits a hepatoprotective effect. Atta et al [29] reported similar results. Moreover, the reduction in liver glycogen observed in toxin-treated rats may be associated with the decrease in the number of hepatocytes, which in turn may result in decreased hepatic capacity to synthesise glycogen and consequently a decrease in liver weight.…”

Section: Diclofenac-induced Hepatotoxicitysupporting

confidence: 76%

Assessment of anti-inflammatory and hepatoprotective potency of Polyalthia longifolia var. pendula leaf in Wistar albino rats

2008

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The objective of the present study was to screen various solvent extracts of Polyalthia longifolia var. pendula (Annonaceae) leaf for anti-inflammatory activity and to evaluate the anti-inflammatory and hepatoprotective potency of the potent solvent extract. Successive extraction was performed with six different solvents, viz. petroleum ether, hexane, toluene, chloroform, acetone and methanol. Toluene, chloroform, acetone and methanol were used in acute inflammatory studies; the results revealed methanol as most potent extract. Hence three concentrations of methanolic extract (300, 600, 900 mg/kg) were used to evaluate its potential as an anti-inflammatory and hepatoprotective agent. Diclofenac sodium was used as the toxicant in hepatoprotective studies, in which various serum biochemical parameters and liver glycogen were assessed. The three concentrations of methanol showed anti-inflammatory activity comparable to that of the control (Diclofenac sodium). All the serum biochemical parameters studied revealed the hepatoprotective nature of the methanol extract, but a concentration effect was not observed. The results indicated that the methanolic extract of Polyalthia longifolia var. pendula leaf possesses significant anti-inflammatory and hepatoprotective activity. However, the appropriate effective concentration needs to be determined.

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Section: Diclofenac-induced Hepatotoxicitysupporting

confidence: 76%

Assessment of anti-inflammatory and hepatoprotective potency of Polyalthia longifolia var. pendula leaf in Wistar albino rats

2008

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“…Its antioxidant and free radical scavenging activity are contributed by its total phenol contents, flavonoids and caffeic acid derivatives such as plantamajoside and acteoside [10] . Although the hepatoprotective studies have been done previously, those were done on CCl 4 -induced liver injury and P. major was given prior to CCl 4 exposure [17,18] . Based on the promising effect of P. major on liver injury, we took up the challenge of real case scenario and P. major was given after APAP toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…The extensive in vitro and in vivo studies showed its hypoglycaemic effect [12] , haemopoietic activity on the bone marrow and spleen cells [13], antiulcer effect on asprin-induced gastric ulcer [14] , antibacterial effect on Staphylococcus aureus and Escherichia coli and antiinflammatory properties [15,16] . Its hepatoprotective activity against carbon tetrachloride (CCl 4 ) toxicity has been observed [17,18]. Based on the promising effect of P. major on liver injury, the present study was aimed to explore its effect on APAP toxicity and determine the potential protective mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Hussan

Basah

Yusof

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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A B S T R A C TObjective: To determine the effect of Plantago major (P. major) extract on the liver injury following acetaminophen (APAP) toxicity. Methods: The male Sprague Dawley rats (n = 38) were randomly divided into normal control (n = 6) and experiment (n = 32) groups. The latter was subdivided into four groups and induced with APAP (1 000 mg/kg) per oral, followed by P. major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P. major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury.

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“…Thus, it can be stated that tarvada roots have shown more potent hepatoprotective activity as a prophylactic and anti-hepatotoxic agent than as a therapeutic agent. Review of the literature revealed that anthraquinone glycosides, such as rubiadin (Rao et al, 2006) and emodin (Bhadauria, 2010), tannins and phenolic compounds (Atta et al, 2006) have potent hepatoprotective activity. Flavone glycosides such as hirsutrin, avicularin, quercetin, rutin (Janbaz et al, 2002) and apigenin (Sayed et al, 2011) have significant antioxidant and hepatoprotective activities.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Jaydeokar

Bandawane

Bibave

et al. 2014

Pharmaceutical Biology

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Context: Tarvada [Cassia auriculata Linn. (Caesalpiniaceae)] is used against liver ailments in Indian folk medicine, but there is a lack of scientific evidence for this traditional claim. Objective: The present study investigated the protective effect of methanol extract of tarvada (MECA) roots on ethanol and antitubercular drug induced hepatotoxicity in rats. Materials and methods: In the therapeutic model, ethanol (40%, 4 g/kg b.w., p.o.) was administered to rats for 21 days and the intoxicated rats were treated with MECA (300 and 600 mg/kg, b.w.) and silymarin (100 mg/kg, b.w.) for next 7 days. In the prophylactic model, MECA and silymarin were administered simultaneously along with a combination of isoniazid (27 mg/kg, b.w.), rifampicin (54 mg/kg, b.w.) and pyrazinamide (135 mg/kg, b.w.) for 30 days. After the study duration, serum levels of AST, ALT, ALP, total bilirubin, total cholesterol, total protein, albumin were estimated along with hepatic catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA) and liver histopathology in each group. Results: Administration of tarvada root extract significantly (p50.01 and p50.05) lowered the elevated levels of serum AST, ALT, ALP, total bilirubin, total cholesterol, total protein and restored the abnormal levels of enzymatic antioxidants and MDA in liver due to toxicant administration in a dose-dependent manner. These results were confirmed by histopathological analysis. Discussion and conclusion: Results suggest that tarvada root extract possess potent hepatoprotective activity against ethanol and antitubercular drug-induced hepatotoxicity in rats, which could be due to an inhibition of hepatic metabolizing enzymes and antioxidant activity.

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Potential protective effect of some plant extracts against carbon tetrachloride – induced hepatotoxicity

Cited by 16 publications

References 25 publications

Assessment of anti-inflammatory and hepatoprotective potency of Polyalthia longifolia var. pendula leaf in Wistar albino rats

Assessment of anti-inflammatory and hepatoprotective potency of Polyalthia longifolia var. pendula leaf in Wistar albino rats

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

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