The antinociceptive effect of tramadol-venlafaxine combination on the paw withdrawal threshold in a rat model of neuropathic pain

Modification of morphine analgesia by venlafaxine in diabetic neuropathic pain model

“…Our results are consistent with a previous finding where the selective serotonin reuptake inhibitor (SSRI), fluoxetine, enhanced antinociceptive and antiallodynic effects of morphine in diabetic and sciatic-nerve-ligated mice [24]. Other reports also revealed that acute co-administration of serotonin and noradrenaline reuptake inhibitors (milnacipram and venlafaxine) and a tricyclic antidepressant (doxepin) with tramadol potentiated the antihyperalgesic effect of tramadol in the CCI model of neuropathic pain [17,26,28].…”

Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain

“…The antidepressant venlafaxine acts to increase extracellular levels of 5-HT and NA via inhibition of transporter function (Koch et al 2003). Venlafaxine has been reported to attenuate signs of spontaneous pain and hindpaw mechanical and thermal hypersensitivity in animal models of tonic nociception and neuropathic pain (Marchand et al 2003a;Iyengar et al 2004;Uyar et al 2003). Correspondingly, venlafaxine has also been shown to alleviate pain in patients with diabetic neuropathy, painful polyneuropathy and fibromyalgia (Dwight et al 1998;Enggaard et al 2001;Simpson 2001;Sindrup et al 2003).…”

Ellagic acid enhances the antinociceptive action of venlafaxine in mouse acetic acid-induced pain: An isobolographic analysis

“…However, several studies showed the importance of the peripheral antinociceptive activity of antidepressant drugs [27,28]. VLF, a widely used newer generation antidepressant, has been cited as a promising drug for pain control [29]. This drug has been reported to inhibit signs of spontaneous pain and hindpaw mechanical and thermal hypersensitivity in animal models of tonic nociception and neuropathic pain [29][30][31].…”

“…VLF, a widely used newer generation antidepressant, has been cited as a promising drug for pain control [29]. This drug has been reported to inhibit signs of spontaneous pain and hindpaw mechanical and thermal hypersensitivity in animal models of tonic nociception and neuropathic pain [29][30][31]. VLF has also shown to relieve pain in patients with diabetic neuropathy, painful polyneuropathy and fibromyalgia [13,[32][33][34].…”