The anxiolytic effect of testosterone in the rat is mediated via the androgen receptor

Hodosy, Július; Zelmanová, Dorota; Majzúnová, Miroslava; Filová, Barbora; Malinova, M; Ostatníková, Daniela; Celec, Peter

doi:10.1016/j.pbb.2012.04.005

Cited by 60 publications

(46 citation statements)

References 43 publications

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“…Their study involved long-term (8-week) treatment, allowing for the study of genomic effects. In contrast, many authors have suggested that the genomic effects of testosterone on behavior are anxiolytic and mediated via the androgen receptor [7,9,10] .…”

Section: Discussionmentioning

confidence: 96%

“…In the other tests, we found no significant differences after estradiol supplementation. Application of testosterone reported an anxiolytic effect [7,9,10] . A study by Aikey et al…”

Section: Discussionmentioning

confidence: 99%

“…Results from animal studies suggest that testosterone has antidepressant [5,6] and anxiolytic effects [6,7] .…”

Section: Introductionmentioning

confidence: 99%

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Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway

et al. 2015

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Besides their known slow genomic effects, testosterone and estradiol have rapid effects in the brain. However, their impact on mood-related behavior is not clear. The aim of this study was to investigate the non-genomic pathway of testosterone and estradiol in the amygdala in relation to anxiety and depressive-like behavior. Sham-operated and gonadectomized male rats (GDX) supplemented with testosterone propionate, estradiol, or olive oil were used. Five minutes after administration, anxiety and depression-like behavior were tested. Estradiol increased anxiolytic behavior in the open-field test compared to the GDX group, but administration of testosterone had no significant effect. Besides, c-Fos expression in the medial nucleus of the amygdala significantly increased after testosterone treatment compared to the GDX group, while no significant difference was observed in the central and the basolateral nuclei of the amygdala in the testosterone-treated group compared to the GDX group. In conclusion, estradiol had an anxiolytic effect via a rapid pathway, but no rapid effect of testosterone on anxiety was found. Further studies elucidating whether the rapid effect is mediated by a non-genomic pathway are needed.

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Section: Discussionmentioning

confidence: 96%

“…In the other tests, we found no significant differences after estradiol supplementation. Application of testosterone reported an anxiolytic effect [7,9,10] . A study by Aikey et al…”

Section: Discussionmentioning

confidence: 99%

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Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway

et al. 2015

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“…Considering that ERb mediates the anxiolytic effect of estrogens (Oyola et al, 2012) and AR is involved in cognitive processes and mood of testosterone in rodents (Hodosy et al, 2012), the present study examined the protein expressions of ERb and AR in the hippocampus. The results of Western blot analyses showed that, compared with the same sex vehicle controls at same age, perinatal exposure to DEHP (10, 50, 200 mg kg À1 d À1 ) significantly down-regulated the expression of AR in males at age of 6 w (p < 0.05, p < 0.01) or of ERb in females at age of 6 w (p < 0.05, p < 0.01, p < 0.001) and 12 w (p < 0.05; DEHP at 200 mg kg À1 d À1 slightly inhibited the expression of AR but significantly down-regulated ERb in males at age of 12 w (p < 0.05).…”

Section: Erb and Ar Levels And Phosphorylation Of Erk1/2 In The Hippomentioning

confidence: 99%

“…Recent study found that ventral hippocampal lesions reduced anxiety (Barkus et al, 2010). The anxiolytic properties of estrogens have been reported to be mediated by ERb (Oyola et al, 2012), and AR is believed to be involved in the anxiolytic effect of testosterone in rat (Hodosy et al, 2012). Carbone's group recently found that exposure to DEHP at 30 mg kg À1 d À1 from PND 1 to the day of behavior test at age of day 45 or 60 significantly increased anxiety-like behavior in male but not in female rats (Carbone et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Perinatal exposure to di-(2-ethylhexyl) phthalate affects anxiety- and depression-like behaviors in mice

et al. 2015

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Inhibition of androgenic pathway impairs encoding of cerebellar‐dependent motor learning in male rats

Panichi

Dieni

Sullivan

et al. 2022

J of Comparative Neurology

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Cerebellar-dependent learning is essential for the adaptation of motor and no motor behaviors to changing contexts, and neuroactive steroids-mainly referred to as estrogens-may regulate this process. However, the role of androgens in this process has not been established, although they may affect cerebellar physiology. Thus, this study aims to determine whether the activation of androgenic neural pathways may take part in controlling the vestibuloocular (VOR) and optokinetic reflexes (OKR), which depend on a defined cerebellar circuitry. To answer this question, we acutely blocked the activation of androgen receptors (Ars) using systemic administration of the Ars antagonist flutamide (FLUT; 20 mg/Kg) in peripubertal male rats. Then, we evaluated the FLUT effect on general oculomotor performance in the VOR and OKR as well as VOR adaptive gain increases and decreases. We used a paradigm causing fast VOR adaptation that combined in phase/out phase visuo-vestibular stimulations. We found that FLUT impaired the gain increase and decrease in VOR adaptation. However, FLUT altered neither acute nor overtime basal ocular-motor performance in the VOR or OKR. These findings indicate that the activation of androgenic neural pathways participates in phenomena leading to fast VOR adaptation, probably through the modulation of plasticity mechanisms that underlie adaptation of this reflex. Conversely, androgens may not be essential for neural information processing demands in basal ocular-motor reflexes. Moreover, our results suggest that androgens, possibly testosterone and dihydrotestosterone, could rapidly regulate motor memory encoding in the VOR adaptation, acting at both cerebellar and extracerebellar plasticity sites.

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The anxiolytic effect of testosterone in the rat is mediated via the androgen receptor

Cited by 60 publications

References 43 publications

Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway

Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway

Perinatal exposure to di-(2-ethylhexyl) phthalate affects anxiety- and depression-like behaviors in mice

Inhibition of androgenic pathway impairs encoding of cerebellar‐dependent motor learning in male rats

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