2022
DOI: 10.1016/j.cellsig.2022.110418
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The Apelin-APJ axis alleviates LPS-induced pulmonary fibrosis and endothelial mesenchymal transformation in mice by promoting Angiotensin-Converting Enzyme 2

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Cited by 10 publications
(8 citation statements)
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“…In a mouse model of LPSinduced pulmonary fibrosis, Apelin-APJ was found to inhibit the ubiquitination of ACE2, thereby upregulating its expression and alleviating mesenchymal transition of endothelial cells and pulmonary fibrosis. 91 These findings collectively reveal the regulatory role of ACE2 ubiquitination in RAS-related diseases and provide a theoretical basis for the treatment of lung fibrosis and cardiovascular diseases.…”
Section: Ubiquitination Of Ace2mentioning
confidence: 72%
“…In a mouse model of LPSinduced pulmonary fibrosis, Apelin-APJ was found to inhibit the ubiquitination of ACE2, thereby upregulating its expression and alleviating mesenchymal transition of endothelial cells and pulmonary fibrosis. 91 These findings collectively reveal the regulatory role of ACE2 ubiquitination in RAS-related diseases and provide a theoretical basis for the treatment of lung fibrosis and cardiovascular diseases.…”
Section: Ubiquitination Of Ace2mentioning
confidence: 72%
“…Referring to pulmonary fibrosis, several studies affirmed that apelin participated in the process of melatonin alleviating bleomycin-induced pulmonary injury and evodiamine alleviating lipopolysaccharide-induced pulmonary inflammation and fibrosis 47 , 49 . Apelin can also directly alleviate lipopolysaccharide-induced pulmonary fibrosis in mice by promoting angiotensin-converting enzyme 2 50 or suppressing TGF-β1 signaling 51 . However, to date, most research focused on the protective effect of apelin on fibrosis by administrating apelin before or immediately after the stimulation 50 , 51 .…”
Section: Discussionmentioning
confidence: 99%
“… 92 LPS-induced ALI/ARDS and pulmonary fibrosis mimic sepsis-related pulmonary ALI and pulmonary fibrosis. 93 …”
Section: The Involvement Of the Apelin/apj System In Septic Conditionsmentioning
confidence: 99%
“… 101 Apelin was shown to promote ACE2 expression, thereby reducing endothelial-mesenchymal transition and preventing sepsis-associated pulmonary fibrosis in mice. 93 Additionally, inhibition of APJ exacerbated pulmonary fibrosis. This is further evidence of the protective role of the Apelin/APJ system against organ damage in sepsis.…”
Section: The Involvement Of the Apelin/apj System In Septic Conditionsmentioning
confidence: 99%