The Application of Pectin-Insulin Patch on Streptozotocin-Induced Diabetic Rats: Implications in the Hippocampal Function

Sibiya, Ntethelelo; Mabandla, Musa V.

doi:10.4172/2155-6156.1000779

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…None of the many therapeutic agents targeting the pathophysiology of IRI have transcended the clinical barrier. However, insulin has demonstrated a potential to modulate the leukocyte-endothelial interaction during IRI in in vitro and pre-clinical studies [ 14 , 24 ]. Insulin is also the most used therapeutic agent in clinical trials on IRI.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Insulin on Ischemia Reperfusion Injury in Human Skeletal Muscle

Gooneratne

Homer‐Vanniasinkam

Wijeyaratne³

2022

Vasc Specialist Int

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Purpose: Exaggerated leucocyte activity is a crucial step in the pathophysiology of skeletal muscle ischemia-reperfusion injury (IRI). We tested the hypothesis that insulin, via its' anti-leukocyte activity, attenuates skeletal muscle IRI in humans. Materials and Methods: This randomized, blinded, placebo-controlled trial was conducted in patients with skeletal muscle ischemia who required revascularization. Treatment protocols were similar among them except for the insulin group, which received an infusion of insulin at 2.5 U/h. The degree of endothelial adhesiveness; leukocyte activity and pro-inflammatory status via P-selectin, tumor necrosis factor (TNF)-alpha, and myeloperoxidase (MPO) levels in the venous effluent; and clinical outcomes were measured. Results: Twenty-four consenting patients were randomized to the insulin or control group. There were no significant differences between the two groups except for the median serum insulin level, which was higher in the insulin group (P<0.01). No serious intervention-related adverse events were observed. P-selectin (55.04-99.86 pg/mL; P<0.001), pg/mL; P<0.001), and TNF-alpha (12.16-36.01 pg/mL; P<0.001) levels demonstrated a significant increase post-reperfusion in the 'control' group, reaching a peak value at 2 hours post-reperfusion. The increase in all three markers from baseline was significantly diminished in the insulin group at the two-hour (P-selectin, P=0.001; MPO, P=0.001; TNF-alpha, P=0.005) and four-hour (P-selectin, P=0.003; MPO, P=0.002; TNF-alpha, P=0.01) intervals. The differences in clinical outcomes between the insulin and control groups were not statistically significant. Conclusion:In clinical practice, insulin has the potential to attenuate the severity of skeletal muscle IRI inhibiting P-selectin, MPO, and TNF-alpha levels.

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Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Insulin on Ischemia Reperfusion Injury in Human Skeletal Muscle

Gooneratne

Homer‐Vanniasinkam

Wijeyaratne³

2022

Vasc Specialist Int

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“…Damage to podocytes results in proteinuria and, eventually, renal failure, which is due to a decrease in glomerular permeability due to mesangial expansion [ 38 , 39 ]. Apart from oxidative stress and associated inflammation, podocyte injury or death could be attributed to insulin resistance [ 40 ]. These cells, which are crucial for the integrity of the glomerular basement membrane, have been reported to be insulin-responsive, and hence, their survival is insulin-dependent.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effects of a Rhenium (V) Compound with Uracil-Derived Ligand Markers Associated with Hyperglycaemia-Induced Renal Dysfunction in Diet-Induced Prediabetic Rats

Siboto

Akinnuga

Khumalo

et al. 2022

IJMS

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Kidney disease is characterised by the improper functioning of the kidney as a result of kidney damage caused by hyperglycaemia-induced oxidative stress. The moderate hyperglycaemia seen in prediabetes can be treated using a combination of metformin and lifestyle interventions (low-calorie diets and exercising). However, patients have been reported to over-rely on pharmacological interventions, thus decreasing the efficacy of metformin, which leads to the development of type 2 diabetes mellitus (T2DM). In this study, we investigated the effects of a rhenium (V) compound in ameliorating renal dysfunction in both the presence and absence of dietary modification. Kidney function parameters, such as fluid intake and urine output, glomerular filtration rate (GFR), kidney injury molecule (KIM 1), creatinine, urea, albumin and electrolytes, were measured after 12 weeks of treatment. After treatment with the rhenium (V) compound, kidney function was restored, as evidenced by increased GRF and reduced KIM 1, podocin and aldosterone. The rhenium (V) compound ameliorated kidney function by preventing hyperglycaemia-induced oxidative stress in the kidney in both the presence and absence of dietary modification.

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A systematic review of preclinical studies exploring the role of insulin signalling in executive function and memory

Ottomana,

Presta,

O’Leary

et al. 2023

Neuroscience & Biobehavioral Reviews

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The Application of Pectin-Insulin Patch on Streptozotocin-Induced Diabetic Rats: Implications in the Hippocampal Function

Cited by 4 publications

References 48 publications

Beneficial Effects of Insulin on Ischemia Reperfusion Injury in Human Skeletal Muscle

Beneficial Effects of Insulin on Ischemia Reperfusion Injury in Human Skeletal Muscle

Ameliorative Effects of a Rhenium (V) Compound with Uracil-Derived Ligand Markers Associated with Hyperglycaemia-Induced Renal Dysfunction in Diet-Induced Prediabetic Rats

A systematic review of preclinical studies exploring the role of insulin signalling in executive function and memory

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