To model the subgrid-scale (SGS) scalar variance under supercritical-pressure conditions, an equation is first derived for it. This equation is considerably more complex than its equivalent for atmospheric-pressure conditions. Using a previously created direct numerical simulation (DNS) database of transitional states obtained for binary-species systems in the context of temporal mixing layers, the activity of terms in this equation is evaluated, and it is found that some of these new terms have magnitude comparable to that of governing terms in the classical equation. Most prominent among these new terms are those expressing the variation of diffusivity with thermodynamic variables and Soret terms having dissipative effects. Since models are not available for these new terms that would enable solving the SGS scalar variance equation, the adopted strategy is to directly model the SGS scalar variance. Two models are investigated for this quantity, both developed in the context of compressible flows. The first one is based on an approximate deconvolution approach and the second one is a gradient-like model which relies on a dynamic procedure using the Leonard term expansion. Both models are successful in reproducing the SGS scalar variance extracted from the filtered DNS database, and moreover, when used in the framework of a probability density function (PDF) approach in conjunction with the b-PDF, they excellently reproduce a filtered quantity which is a function of the scalar. For the dynamic model, the proportionality coefficient spans a small range of values through the layer cross-stream coordinate, boding well for the stability of large eddy simulations using this model.