2017
DOI: 10.1128/aem.01189-17
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The Arsenic Resistance-Associated Listeria Genomic Island LGI2 Exhibits Sequence and Integration Site Diversity and a Propensity for Three Listeria monocytogenes Clones with Enhanced Virulence

Abstract: In the foodborne pathogen , arsenic resistance is encountered primarily in serotype 4b clones considered to have enhanced virulence and is associated with an arsenic resistance gene cluster within a 35-kb chromosomal region, genomic island 2 (LGI2). LGI2 was first identified in strain Scott A and includes genes putatively involved in arsenic and cadmium resistance, DNA integration, conjugation, and pathogenicity. However, the genomic localization and sequence content of LGI2 remain poorly characterized. Here w… Show more

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Cited by 54 publications
(117 citation statements)
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“…Interestingly, LGI2 has been found primarily in L. monocytogenes , that is, is largely absent from nonpathogenic Listeria spp. (Lee, Ward, Jima, Parsons, & Kathariou, ). It also shows strong propensity for the hypervirulent clone CC2 and a specific integration site but can also be encountered in diverse clones and integration sites (Lee et al, ; Maury et al, ; Pasquali et al, ).…”
Section: Cadmium Resistance In Listeriamentioning
confidence: 99%
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“…Interestingly, LGI2 has been found primarily in L. monocytogenes , that is, is largely absent from nonpathogenic Listeria spp. (Lee, Ward, Jima, Parsons, & Kathariou, ). It also shows strong propensity for the hypervirulent clone CC2 and a specific integration site but can also be encountered in diverse clones and integration sites (Lee et al, ; Maury et al, ; Pasquali et al, ).…”
Section: Cadmium Resistance In Listeriamentioning
confidence: 99%
“…It also shows strong propensity for the hypervirulent clone CC2 and a specific integration site but can also be encountered in diverse clones and integration sites (Lee et al, ; Maury et al, ; Pasquali et al, ). LGI2 is typically chromosomal (Kuenne et al, ; Lee et al, ), and only rarely plasmid‐borne (Hingston et al, ). Whole genome sequence analysis revealed strong diversification of LGI2 in certain strains, mostly in the hypervirulent clone CC1 (Lee et al, ).…”
Section: Cadmium Resistance In Listeriamentioning
confidence: 99%
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