The association between alopecia areata and anxiety, depression, schizophrenia, and bipolar disorder: a population-based study

Bitan, Dana Tzur; Berzin, Daniella; Kridin, Khalaf; Cohen, Arnon D

doi:10.1007/s00403-021-02247-6

Cited by 30 publications

(32 citation statements)

References 41 publications

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“…When looking at depression, the aforementioned meta-analysis found that people with AA are 2.71 times more likely to experience depression ( 12 ). This result is corroborated by other studies reporting people with AA to be more likely to be diagnosed with depression ( 13 , 15 ). As for anxiety, it is unclear how people with AA compare to people with other dermatological diagnoses ( 16 , 17 ).…”

Section: Introductionsupporting

confidence: 87%

Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis

Dalen

Muller

Kasperkovitz-Oosterloo³

et al. 2022

Front. Med.

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IntroductionAlopecia areata (AA) is a non-scarring hair loss condition, subclassified into AA, alopecia universalis, and alopecia totalis. There are indications that people with AA experience adverse psychosocial outcomes, but previous studies have not included a thorough meta-analysis and did not compare people with AA to people with other dermatological diagnoses. Therefore, the aim of this systematic review and meta-analysis was to update and expand previous systematic reviews, as well as describing and quantifying levels of anxiety, depression, and quality of life (QoL) in children and adults with AA.MethodsA search was conducted, yielding 1,249 unique records of which 93 were included.ResultsReview results showed that people with AA have higher chances of being diagnosed with anxiety and/or depression and experience impaired QoL. Their psychosocial outcomes are often similar to other people with a dermatological condition. Meta-analytic results showed significantly more symptoms of anxiety and depression in adults with AA compared to healthy controls. Results also showed a moderate impact on QoL. These results further highlight that AA, despite causing little physical impairments, can have a significant amount on patients’ well-being.DiscussionFuture studies should examine the influence of disease severity, disease duration, remission and relapse, and medication use to shed light on at-risk groups in need of referral to psychological care.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42022323174].

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Section: Introductionsupporting

confidence: 87%

Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis

Dalen

Muller

Kasperkovitz-Oosterloo³

et al. 2022

Front. Med.

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“…Thereby age is an independent factor for anxiety and depression in LN patients 26 . (3) Alopecia could have a negative impact on personal appearance, which might influence an individual's career and daily social, and this might subsequently induce the occurrence of anxiety; therefore, alopecia could be an independent factor for anxiety 27,28 . (4) Similar to previous studies, long‐term systematic inflammation could harm mental health, thus CRP exhibits to be an independent factor for anxiety 29,30 …”

Section: Discussionmentioning

confidence: 57%

Anxiety and depression prevalence and their risk factors in lupus nephritis patients: A case–control study

Zhan²

2022

Immunity Inflam & Disease

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Introduction Anxiety and depression exhibit a high prevalence in systemic lupus erythematosus (SLE) patients, while this issue is seldom explored in lupus nephritis (LN). Hence, the current study aimed to investigate the prevalence of anxiety and depression, and the risk factors for these mental disorders in LN patients. Methods Fifty LN patients, 50 non‐LN SLE patients, and 50 health control (HCs) were enrolled. The Hospital Anxiety and Depression Scale (HADS) for anxiety (HADS‐A) score and HADS for depression (HADS‐D) score were evaluated. Results HADS‐A score was highest in LN patients (median 7.0, interquartile range [IQR]: 6.0–10.0), followed by non‐LN SLE patients (median 6.0, IQR: 5.0–8.0), and lowest in HCs (median 5.0, IQR: 3.0–7.0) ( p < .001). Besides, the anxiety rate was most frequent in LN patients (38.0%), followed by non‐LN SLE patients (28.0%), least common in HCs (12.0%) ( p = .011). HADS‐D score was highest in LN patients (median 7.5, IQR: 6.0–11.0), followed by non‐LN SLE patients (median 6.0, IQR: 5.0–8.3), and lowest in HCs (median 4.0, IQR: 2.0–6.3) ( p < .001). Similarly, the depression rate was most prevalent in LN patients (50.0%), subsequently the non‐LN SLE patients (30.0%), and rarest in HCs (10.0%) ( p < .001). Furthermore, in LN patients, age ( p = .009), LN activity index ( p = .020), alopecia ( p = .023), 24 h proteinuria ( p = .044), and C‐reactive protein ( p = .049) were independently correlated with higher anxiety risk; meanwhile, age ( p = .001) and LN activity index ( p = .009) were independently correlated with higher depression risk. Conclusion Anxiety and depression are highly prevalent, which link to aging, alopecia, inflammation, and severe renal involvement in LN patients.

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“…Moreover, severe alopecia areata, in which the total area of hair loss is greater than 50% of the scalp area, is more common in women ( 21 ). Female alopecia areata patients are also more likely to have anxiety-related disorders, such as trait anxiety, social phobia, and social anxiety, and develop mental disorders, which have a greater adverse effect on the quality of life and increase the disease burden ( 2 , 22 ). The global incidence and DALY rates of alopecia areata were higher in the 20–24- and 30–34-year age groups for males, females, and both sexes combined.…”

Section: Discussionmentioning

confidence: 99%

“…It affects 2% of the general population ( 1 ). In some patients, it may be persistent, especially when hair loss is widespread, and it is an important cause of mental disorders, such as depression, anxiety, and psychosocial distress ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Trends in Alopecia Areata at the Global, Regional, and National Levels

Wang

Pan

Wu³

2022

Front. Immunol.

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BackgroundNo comprehensive studies have been published on the global burden of alopecia areata since 2010.ObjectiveWe aimed to measure the global, regional, and national incidence of alopecia areata and disability-adjusted life-years (DALYs) by age, sex, and socio-demographic index (SDI) value from 1990 to 2019.MethodsData were extracted from the Global Burden of Disease Study 2019. Estimated annual percentage changes (EAPCs) were calculated to quantify temporal trends in the age-standardized rates of alopecia areata incidence and DALYs. The correlations between EAPCs in the age-standardized rates and SDI values were also analyzed.ResultsFrom 1990 to 2019, the alopecia areata incidence number and the associated number of DALYs increased globally by 49.14%, and 49.51%, respectively. The global age-standardized incidence rate decreased (EAPC, −0.13; 95% confidence interval [CI], −0.13 to −0.12) and the age-standardized DALY rate showed a downward trend (EAPC, −0.12; 95% CI, −0.13 to −0.11). The largest increases in the age-standardized incidence rate and age-standardized DALY rate were observed in Low SDI quintile and Western Sub-Saharan Africa regions. The regions with the greatest changes in the incidence of alopecia areata were Central Sub-Saharan Africa and Western Sub-Saharan Africa. The three countries with the largest increases in alopecia areata incidence from 1990 to 2019 were Kuwait (EAPC, 0.15), South Sudan (EAPC, 0.12), and Nigeria (EAPC, 0.11). The age-standardized incidence rate was higher in females than in males.ConclusionGlobally, both the age-standardized incidence rate and age-standardized DALY rate of alopecia areata showed decreasing trends. Future preventive strategies should focus on low-income countries, Central Sub-Saharan Africa, Western Sub-Saharan Africa, Kuwait, South Sudan, Nigeria.

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The association between alopecia areata and anxiety, depression, schizophrenia, and bipolar disorder: a population-based study

Cited by 30 publications

References 41 publications

Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis

Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis

Anxiety and depression prevalence and their risk factors in lupus nephritis patients: A case–control study

Epidemiological Trends in Alopecia Areata at the Global, Regional, and National Levels

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