The association between de novo inflammatory bowel disease and celiac disease

Marcos, N. Manceñido; Villarroya, R. Pajares; Moreno, Silvia Salinas; López, M Rosario Arribas; Redondo, Carmen Comas

doi:10.17235/reed.2019.5535/2018

Cited by 9 publications

(11 citation statements)

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“…In addition, the two sole individuals who had a family history of CeD were among these patients with positive serum tTGAA levels. Subsequent analyses showed that 5 of 6 patients with positive tTGAAs carried the HLA-DQ2 or HLA-DQ8 variants, and 4 of them had duodenal pathology findings consistent with CeD -one with CD and three with UC (2 with ulcerative proctitis, 1 with extensive colitis) (24). In summary, 2.45% of patients newly diagnosed with IBD in this cohort also had CeD.…”

Section: Is Celiac Disease Really Associated With Inflammatory Bowel mentioning

confidence: 70%

“…The novelty in the study herein reported by Manceñido et al resides in the scarce number of reports available on the prevalence of CeD in patients with IBD (24). While the figures the study provides are interesting, no viable references are available for comparison since the actual prevalence of CeD in the Spanish or European population remains unknown, as is also the case with the prevalence of CeD among the genetically susceptible population with IBD.…”

Section: Is Celiac Disease Really Associated With Inflammatory Bowel mentioning

confidence: 87%

“…In the present issue of The Spanish Journal of Gastroenterology (Revista Española de Enfermedades Digestivas), Manceñido et al explore the prevalence of CeD in 163 papatients newly diagnosed with IBD in Spain (65 with CD, 92 with UC, 6 with indeterminate colitis) (24) . Of these, 6 patients (3.68%) had elevated anti-tissue transglutaminase autoantibody (tTGAA) levels, which is characteristic of autoimmune inflammatory response in CeD.…”

Section: Is Celiac Disease Really Associated With Inflammatory Bowel mentioning

confidence: 99%

“…Of these, 6 patients (3.68%) had elevated anti-tissue transglutaminase autoantibody (tTGAA) levels, which is characteristic of autoimmune inflammatory response in CeD. Among these patients 2 had CD (one with colonic involvement, one with ileocolonic localization) and 4 had UC (two with ulcerative proctitis, two with extensive colitis) (24). In addition, the two sole individuals who had a family history of CeD were among these patients with positive serum tTGAA levels.…”

Section: Is Celiac Disease Really Associated With Inflammatory Bowel mentioning

confidence: 99%

See 3 more Smart Citations

Is celiac disease really associated with inflammatory bowel disease?

Escudero-Hernández¹,

Bernardo²,

Arranz³

et al. 2019

Rev Esp Enferm Dig

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Section: Is Celiac Disease Really Associated With Inflammatory Bowel mentioning

confidence: 70%

Section: Is Celiac Disease Really Associated With Inflammatory Bowel mentioning

confidence: 87%

Section: Is Celiac Disease Really Associated With Inflammatory Bowel mentioning

confidence: 99%

Section: Is Celiac Disease Really Associated With Inflammatory Bowel mentioning

confidence: 99%

See 2 more Smart Citations

Is celiac disease really associated with inflammatory bowel disease?

Escudero-Hernández¹,

Bernardo²,

Arranz³

et al. 2019

Rev Esp Enferm Dig

View full text Add to dashboard Cite

“…A gluten-free diet is the only appropriate dietary management of celiac disease [ 60 ]. The prevalence of celiac disease or tissue transglutaminase Antibodies (anti-tTG) antibodies themselves, typical of this disease, is higher among people with diagnosed IBD than in healthy people [ 61 ]. These patients are also more likely to develop non-celiac gluten sensitivity, which causes gastrointestinal symptoms, such as abdominal pain and diarrhea after ingestion of foods containing this compound [ 62 ].…”

Section: Gluten-free Dietmentioning

confidence: 99%

The Modification of the Gut Microbiota via Selected Specific Diets in Patients with Crohn’s Disease

et al. 2021

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Gastrointestinal symptoms in Crohn’s disease (CD) are common and affect the quality of life of patients; consequently, a growing number of studies have been published on diet interventions in this group. The role of the gut microbiota in the pathogenesis and the progression of inflammatory bowel diseases (IBD), including CD, has been widely discussed. Mainly, a decreased abundance of Firmicutes, species of the Bifidobacterium genus, and the Faecalibacterium prausnitzii species as well as a reduced general diversity have been described. In this review article, we summarize available data on the influence of reduction diets on the microbiome of patients with CD. One of the most frequently used elimination diets in CD patients is the low-FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) diet. Although many papers show it may reduce abdominal pain, diarrhea, or bloating, it also reduces the intake of prebiotic substances, which can negatively affect the gut microbiota composition, decreasing the abundance of Bifidobacterium species and Faecalibacterium prausnitzii. Other elimination diets used by IBD patients, such as lactose-free or gluten-free diets, have also been shown to disturb the microbial diversity. On the other hand, CDED (Crohn’s disease exclusion diet) with partial enteral nutrition not only induces the remission of CD but also has a positive influence on the microbiota. The impact of diet interventions on the microbiota and, potentially, on the future course of the disease should be considered when nutritional guidelines for IBD patients are designed. Dietetic recommendations should be based not only on the regulation of the symptoms but also on the long-term development of the disease.

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