The association between endothelial nitric oxide synthase gene G894T polymorphism and hypertension in Han Chinese: a case-control study and an updated meta-analysis

Abstract

The relationship between the G894T polymorphism and hypertension in Han Chinese may be attributed to the difference in geographic background of subjects. It is necessary to carry out further research with a large sample size and focusing on gene-environment interactions.

Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms

“…Therefore, several studies have examined whether NOS3 polymorphisms are associated with hypertension. Increased risk of hypertension associated with the variant alleles for the g.-786T>C, g.-665C>T, 4b/4a VNTR and Glu298Asp polymorphisms have been observed in some studies (Uwabo et al, 1998; Jachymova et al, 2001; Hyndman et al, 2002; Pereira et al, 2007; Nejatizadeh et al, 2008; Niu and Qi, 2011; Salvi et al, 2013; Yang et al, 2013; Levinsson et al, 2014; de Miranda et al, 2015; Liu et al, 2015). However, lack of association of these polymorphisms with hypertension was reported in many other studies (Miyamoto et al, 1998; Kato et al, 1999; Benjafield and Morris, 2000; Schneider et al, 2000; Tsujita et al, 2001; Sandrim et al, 2006a; Sandrim et al, 2006c; Pereira et al, 2007; Conen et al, 2008).…”

Polymorphism of the renin-angiotensin system genes and endothelial NO-synthase gene in obese patients with arterial hypertension

“…A meta-regression analysis devoted to the establishment of associations between HD and the polymorphic variant of G894T in the Han ethnic group (China) showed a positive relationship (OR = 1.32, P < 0.001), whereas geographic differences were identified in the relationship between G894T and predisposition to this disease. Thus, among the residents of the southern regions of China the indicated polymorphism may be related to HD (OR = 1.59, P < 0.001), whereas in the northern regions such association is not observed (OR = 1.16, P = 0.12) [48].…”

Prognostic impact of gene polymorphisms in patients with idiopathic sudden sensorineural hearing loss

“…NOS3 is primarily responsible for the generation of NO in the vascular endothelium, and NO produced by eNOS plays a number of crucial roles in the regulation of vascular tone. To date, a large number of studies have shown that polymorphisms in the NOS3 gene affect susceptibility to diseases such as hypertension [12], diabetes mellitus [13], and several autoimmune diseases including Behçet's disease [14]. The G894T (rs1799983) polymorphism in the endothelial nitric oxide synthase (eNOS/NOS3) gene has been implicated in susceptibility to essential hypertension [12], and a decreased frequency of the NOS3 (rs1799983) GG genotype and an increased frequency of the GT genotype was found in patients with Behçet's disease [14].…”

“…To date, a large number of studies have shown that polymorphisms in the NOS3 gene affect susceptibility to diseases such as hypertension [12], diabetes mellitus [13], and several autoimmune diseases including Behçet's disease [14]. The G894T (rs1799983) polymorphism in the endothelial nitric oxide synthase (eNOS/NOS3) gene has been implicated in susceptibility to essential hypertension [12], and a decreased frequency of the NOS3 (rs1799983) GG genotype and an increased frequency of the GT genotype was found in patients with Behçet's disease [14]. In addition, the same NOS3 polymorphism was significantly associated with a risk of idiopathic SSNHL; the OR for the NOS3 polymorphism and idiopathic SSNHL risk was 2.108 (CI: 1.343-3.309) with adjustment for age and sex [15].…”