The association between inflammatory bowel disease and prostate cancer risk: a meta-analysis

Ge, Yuqiu; Shi, Qianqian; Yao, Wenxi; Yang, Cheng; Ma, Gaoxiang

doi:10.1038/s41391-019-0177-7

Cited by 36 publications

(33 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the latter half of the 20th century, IBD was traditionally considered as a disease of westernized nations (including the USA, Canada, Australia, New Zealand, and all countries in western Europe), due to the significantly increased incidence of UC and CD in the western world (2-4) However, recent studies indicate that IBD has become a global condition with the development of newly industrialized countries whose societies have become more westernized (including South America, eastern Europe, Asia, and Africa) (2,5). IBD has been demonstrated with an increased risk of intestinal and extra-intestinal tumors (6)(7)(8)(9)(10)(11). Although recent studies (10,11) showed that IBD patients were at increased risk of bladder cancer (BCa) and prostate cancer (PCa), limited and disparate data were available for incidence of urological malignancies in these patients.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory bowel disease and risk of urinary cancers: a systematic review and pooled analysis of population-based studies

et al. 2021

View full text Add to dashboard Cite

Background: The aim of this study is to elucidate the risk of urologic cancers in patients with Crohn's disease (CD) and ulcerative colitis (UC).Methods: Electronic databases including PubMed, the Cochrane Library, Embase and Web of Science, and manual retrieval were conducted from inception to June 2020. Two reviewers independently searched the above databases and selected the studies using prespecified standardized criteria. The Newcastle-Ottawa Scale was used to assess the risk of bias in the included studies, and this meta-analysis was completed by STATA version 14.2.Results: A total of 12 cohort studies and 4 case-control studies were included in this meta-analysis. Overall, patients with inflammatory bowel disease (IBD) were at significantly increased risk of renal cancer (RCa)[standardized incidence ratio (SIR): 1.53; 95% confidence interval (CI): 1.25-1.80; I 2 =42.4%], but not at increased risk of prostate cancer (PCa), bladder cancer (BCa) and male genital cancer. In the subgroup analysis, CD patients had a significantly higher RCa risk (SIR: 1.95; 95% CI: 1.45-2.44; I 2 =39.9%). Besides, CD patients seemed to be at borderline significantly increased risks of PCa (SIR: 1.07; 95% CI: 0.93-1.20; I 2 =15.1%) and BCa (SIR:1.19; 95% CI: 0.94-1.44; I 2 =0%), and UC patients seemed to be at borderline significantly increased risks of RCa (SIR:1.31; 95% CI: 0.94-1.67; I 2 =48.0%) and PCa (SIR: 1.13; 95% CI: 0.93-1.33; I 2 =73.5%). Notably, we observed that IBD patients in Eastern countries have significantly increased PCa risk (SIR: 2.66; 95% CI: 1.52-3.81; I 2 =13.6%), especially for UC patients (SIR: 3.01; 95% CI: 1.75-4.27; I 2 =0.0%). Conclusions:Our findings indicate that IBD patients with special reference to CD patients increase the risk of RCa. Besides, IBD patients in Asian countries have significantly increased risk of PCa, especially for UC patients. Further studies are warranted to elucidate the potential mechanism of RCa associated with IBD and the differences of the risk of urinary cancers between Eastern and Western countries.

show abstract

Section: Introductionmentioning

confidence: 99%

Inflammatory bowel disease and risk of urinary cancers: a systematic review and pooled analysis of population-based studies

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Moreover, the association between CD and SBS1 is broadly significant across the 12 cancer types in our study. Recent meta-analyses and a large cohort study all conclude that patients with IBD have an increased risk of prostate cancer 68,69,70 , though the previous findings were inconclusive 71,72,73,74,75,76 . Previous studies have proposed that shared risk alleles may partially explain this association 68,75,77 .…”

Section: Discussionmentioning

confidence: 99%

Somatic mutational profiles and germline polygenic risk scores in human cancer

Liu

Gusev

Heng

et al. 2021

Preprint

View full text Add to dashboard Cite

The mutational profile of a cancer reflects the activity of the mutagenic processes which have been operative throughout the lineage of the cancer cell. These processes leave characteristic profiles of somatic mutations called mutational signatures. Mutational signatures, including single-based substitution (SBS) signatures, may reflect the effects of exogenous or endogenous exposures. Here, we used polygenic risk score (PRS) as proxies for exposures and examined the association between somatic mutational profiles and germline PRS in 12 cancer types from The Cancer Genome Atlas project. We found 17 statistically significant associations after Bonferroni correction (p < 3.15×10−5), including positive associations between germline inflammatory bowel disease PRS and number of somatic mutations of signature SBS1 in prostate cancer and APOBEC-related signatures in breast cancer. The age at menarche PRS was inversely associated with mutation counts of SBS1 in prostate cancer. Our analysis suggests that there are robust associations between tumor somatic mutational profiles and germline PRS. These may reflect mechanisms through hormone regulation and immunological responses that contribute to cancer etiology and drive cancer progression.

show abstract

“…Men with BPH and PCa have an increase in zinc excretion compared with healthy men ( 38 ); at the same time, some comorbidities are also known to provoke zinc excretion such as severe or persistent diarrhea, inflammatory bowel diseases, and renal disease. Recent studies and meta-analyses have found an association between inflammatory bowel disease and PCa ( 92 – 94 ). Besides, endogenous factors that prevent zinc absorption are more frequently present in older men, such as malabsorption syndromes (e.g., celiac disease and short bowel syndrome), and GI cancers.…”

Section: Discussionmentioning

confidence: 99%

Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders

Sauer

Vela²,

Vela

et al. 2020

Front. Oncol.

View full text Add to dashboard Cite

Research has been consistently showing the role of zinc (Zn) in prostate function. In this article, we review the current literature on the anatomy and main functions of the prostate, highlighting the role of zinc. In particular, we will review the etiology of benign prostate enlargement (BPH), its prevalence in men over 50, the likelihood of BPH becoming prostate cancer (PCa), and explain the relationship of zinc and apoptosis in the prostate cells and the implications for BPH and PCa. We present a model that explains how endogenous factors provoke excretion of zinc or limit zinc absorption, and how exogenous factors like nutrition and drugs regularly used in men over 50 can significantly decrease zinc status and thereby increase the risk of BPH. Finally, we explain how Zn amino acid (AA) complexes may be capable of avoiding antagonists and inhibitors of zinc absorption, thereby increasing the bioavailability of zinc for the necessary biological processes in the prostate.

show abstract

The association between inflammatory bowel disease and prostate cancer risk: a meta-analysis

Cited by 36 publications

References 32 publications

Inflammatory bowel disease and risk of urinary cancers: a systematic review and pooled analysis of population-based studies

Inflammatory bowel disease and risk of urinary cancers: a systematic review and pooled analysis of population-based studies

Somatic mutational profiles and germline polygenic risk scores in human cancer

Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders

Contact Info

Product

Resources

About