The association between serum cystatin C and residual renal function in peritoneal dialysis patients

Abstract

Introduction This study evaluated the association between serum cystatin C and residual renal function (RRF) in peritoneal dialysis (PD) patients. Methods The ability of cystatin C to predict RRF was assessed. Multivariate linear regression analysis was conducted to measure the impact of particular factors on serum cystatin C levels. Results The study included 141 PD patients. Serum creatinine and cystatin C were negatively correlated with RRF (p < 0.05). Receiver operating characteristic (ROC) curves showed that serum creatinine and cystatin C could both predict RRF status (p < 0.05), but serum cystatin C had a larger area AUC than creatinine (0.893 vs. 0.757, respectively), p < 0.001). Multiple linear regression analysis revealed that RRF Kt/V and Ccr were independent factors affecting serum cystatin C levels (p < 0.001). Conclusion Serum cystatin C levels were closely associated with RRF in PD patients and could reliably predict RRF status. Serum cystatin C levels were determined by RRF, not by PD.

Development and validation of prediction model for technique failure in peritoneal dialysis patients: An observational study

“…Many studies, both in China and other countries, indicated that the levels of serum ALB are inversely correlated with patient mortality, cardiovascular mortality, and technique failure, [19][20][21] because serum ALB is a reactivity index of poor clinical state of severe inflammation, 22 malnutrition, 23 and liver injury. 24 Serum creatinine (Cr) is typically used to estimate glomerular filtration rate and is correlated with residual renal function, 25 which has consistently been an important predictor of improved survival for both HD and PD patients. 26 When we added four variables (diabetes, weight, triglyceride and magnesium), Model 2 became Model 3, the model that had the best predictive efficacy for late technique failure.…”

Clinical significance of serum urea‐to‐creatinine ratio in patients undergoing peritoneal dialysis

“…Additionally, CysC is primarily cleared by residual kidneys, while its PD clearance is very low. Similarly to β2‐MG, serum CysC is also suggested as a useful marker for RKF evaluation [30].…”