The association between serum ferritin levels and post-stroke depression

Zhu, Lin; Han, Bin; Wang, Liping; Chang, Ya‐Ling; Ren, Wenwei; Gu, Yingying; Yan, Mengjiao; Wu, Cunkai; Zhang, Xiang Yang; He, Jincai

doi:10.1016/j.jad.2015.09.074

Cited by 32 publications

(31 citation statements)

References 39 publications

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“…There is no significant difference of their vascular risk factors and lesion location in two groups. Furthermore, NIHSS score, BI score, mRS score are statistically significant between depression group and nondepression group (Table 1), the same as the past studies [13,14].…”

Section: Clinical Measuressupporting

confidence: 80%

Plasma Fibrinogen: An Independent Risk Factor for Post- Stroke Depression

Luan¹,

Hui-ping²,

Zhao³

et al. 2017

Neuropsychiatry

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Section: Clinical Measuressupporting

confidence: 80%

Plasma Fibrinogen: An Independent Risk Factor for Post- Stroke Depression

Luan¹,

Hui-ping²,

Zhao³

et al. 2017

Neuropsychiatry

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“…Unfortunately, the poor quality of the studies done to date do not allow for a definitive connection between PSD and inflammation to be made. In some studies, early markers of inflammation like CRP [57], ferritin [58], and neopterin [59] were associated with the later development of PSD. High serum levels of leptin at days 7 and 30 after stroke have also shown an association with later development of PSD [60].…”

Section: Inflammation and The Biological Basis Of Psdmentioning

confidence: 99%

Inflammation and the Silent Sequelae of Stroke

Becker

2016

Neurotherapeutics

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Depression and fatigue are common after stroke and negatively impact the quality of life of stroke survivors. The biological bases of these symptoms are unknown, but an abundance of data point to a role for inflammation. This review highlights evidence supporting the contribution of inflammation to poststroke depression and poststroke fatigue. Potential treatments for poststroke depression and poststroke fatigue are explored, with a special emphasis on those that modulate the immune response.

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“…Recently, there has been increasing interest in a possible protective and modifiable role of metallic elements, especially Zn and Fe, due to their antioxidant activity (Szkup et al, 2017 ). In depression, peripheral blood markers such as serum ferritin concentrations are most often applied to assess iron levels because they are relatively simple and convenient (Zhu et al, 2016 ). However, given the many factors interfering with iron transport, uptake and storage, serum ferritin concentrations are easily confounded, thereby not accurately reflecting total body iron content (Nielsen et al, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Quantitative Susceptibility Mapping Reveals an Association between Brain Iron Load and Depression Severity

Yao

Zeng

et al. 2017

Front. Hum. Neurosci.

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Previous studies have detected abnormal serum ferritin levels in patients with depression; however, the results have been inconsistent. This study used quantitative susceptibility mapping (QSM) for the first time to examine brain iron concentration in depressed patients and evaluated whether it is related to severity. We included three groups of age- and gender-matched participants: 30 patients with mild-moderate depression (MD), 14 patients with major depression disorder (MDD) and 20 control subjects. All participants underwent MR scans with a 3D gradient-echo sequence reconstructing for QSM and performed the 17-item Hamilton Depression Rating Scale (HDRS) test. In MDD, the susceptibility value in the bilateral putamen was significantly increased compared with MD or control subjects. In addition, a significant difference was also observed in the left thalamus in MDD patients compared with controls. However, the susceptibility values did not differ between MD patients and controls. The susceptibility values positively correlated with the severity of depression as indicated by the HDRS scores. Our results provide evidence that brain iron deposition may be associated with depression and may even be a biomarker for investigating the pathophysiological mechanism of depression.

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The association between serum ferritin levels and post-stroke depression

Cited by 32 publications

References 39 publications

Plasma Fibrinogen: An Independent Risk Factor for Post- Stroke Depression

Plasma Fibrinogen: An Independent Risk Factor for Post- Stroke Depression

Inflammation and the Silent Sequelae of Stroke

Quantitative Susceptibility Mapping Reveals an Association between Brain Iron Load and Depression Severity

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