The association between smoking quantity and hypertension mediated by inflammation in Chinese current smokers

Feng, Dan; Liu, Tao; Su, Dongfang; Wang, Hui; Ding, Peng; He, Yanan; Deng, Xueqing; Hou, Mengjun; Liu, Wenhua; Chen, Weiqing

doi:10.1097/hjh.0b013e328362c21a

Cited by 21 publications

(21 citation statements)

References 53 publications

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“…The effect of active/chronic smoking on blood pressure progression and incidence of hypertension is a complex and controversial issue. In a cross-sectional analysis of Chinese current smokers, smoking quantity was positively associated with hypertension (probably mediated by inflammation) [7]. This editorial commentary will not deal with the claimed mechanisms by which acute and chronic tobacco smoking, respectively, may lead to transient or prolonged changes in blood pressure responses.…”

mentioning

confidence: 98%

Where there's smoke there might be hypertension

Buyzere

2015

Journal of Hypertension

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mentioning

confidence: 98%

Where there's smoke there might be hypertension

Buyzere

2015

Journal of Hypertension

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“…Type 2 diabetes is considered an inflammatory disease and inflammation may play an important role in the pathogenesis of type 2 diabetes [17]. Taylor et al showed that an inflammatory marker of fibrinogen partly mediated the effect of cigarette smoking on depression [18] and we found that CRP mediated the association between smoking quantity and hypertension [19]. Whether CRP also mediates the association between smoking quantity and type 2 diabetes is still unresolved and is the subject of this study.…”

Section: Introductionmentioning

confidence: 62%

“…CRP mediated this association between the smoking quantity and type 2 diabetes, accounting for 50.77% of the association. It should be noted that Taylor et al indicated that an inflammatory marker of fibrinogen partly mediated the effect of cigarette smoking on depression [18] and that our previous study found that CRP mediated the association between smoking quantity and hypertension [19]. …”

Section: Discussionmentioning

confidence: 99%

Mediation Role of C-Reactive Protein on the Association between Smoking Quantity and Type 2 Diabetes in Current Chinese Smokers

Feng

Liu

Wang

et al. 2014

Journal of Diabetes Research

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Objective. Previous studies have indicated that cigarette smokers are more likely to develop type 2 diabetes and that both smoking and type 2 diabetes are associated with C-reactive protein (CRP). This study examined whether CRP mediates the association between smoking quantity and type 2 diabetes. Methods. Nine hundred and eighty-four current Chinese smokers were selected from a community-based chronic disease survey conducted in Guangzhou and Zhuhai. Type 2 diabetes was defined according to the WHO 1999 criteria. CRP was measured with flow cytometry. Binary logistic regression was performed to assess the mediation. Results. A positive association was observed between smoking quantity and type 2 diabetes (P < 0.05). After controlling for potential confounders, daily cigarette consumption was significantly associated with higher CRP levels. Current smokers with type 2 diabetes had higher CRP levels than smokers without type 2 diabetes. The association between the smoking quantity and type 2 diabetes was mediated by CRP, which accounted for 50.77% of the association. Conclusions. This study provides further evidence that smoking quantity is positively associated with type 2 diabetes and suggests that the association between smoking and type 2 diabetes might be mediated by CRP.

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“…However, in contrast to the other two oxidative stress markers, MCP-1 levels showed no association with OSA severity in our study. It was reported that smokers with hypertension had higher MCP-1 levels than smokers who were normotensive [45]. It has also been suggested that serum MCP-1 levels are significantly higher in COPD patients than in healthy smokers [46].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function

et al. 2016

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Background: Endothelial dysfunction has been recognized to occur in the context of obstructive sleep apnea (OSA) or tobacco smoking. However, the deleterious effect on vascular function with concurrence of both conditions is largely unknown. Objective: To investigate whether the concurrence of OSA and smoking poses an additive detriment to endothelial dysfunction. Methods: Chinese men without a history of chronic medical illness were invited to complete a questionnaire including smoking pack-year exposure, polysomnography and peripheral arterial tonometry (PAT) for endothelial function. Serum 8-isoprostane, advanced oxidation protein products (AOPP) and monocyte chemo-attractant protein-1 (MCP-1) were measured. Results: 114 men were successfully enrolled. PAT ratio, adjusted for age and body mass index, correlated inversely with overall severity of OSA: apnea-hypopnea index (AHI), r = -0.160 (p = 0.092); oxygen desaturation index, r = -0.214 (p = 0.024); duration of oxygen saturation <90%, r = -0.219 (p = 0.020); and minimum oxygen saturation, r = 0.250 (p = 0.008). The PAT ratio decreased with increasing pack-year group (p = 0.018). It was lower with concurrent smoking history and moderate-severe OSA (AHI ≥15/h) compared to having one or neither factor (p = 0.011). Serum levels of 8-isoprostane and AOPP were positively related to severity of OSA, while MCP-1 correlated with smoking quantity. Multiple linear regression analyses showed that severity of intermittent hypoxia, MCP-1 and pack-year exposure were independent predictors of PAT ratio. Conclusion: While OSA, in particular intermittent hypoxemia, and tobacco smoking were independent risk factors, the concurrence of moderate-severe OSA and smoking was associated with the most severe impairment in endothelial function.

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The association between smoking quantity and hypertension mediated by inflammation in Chinese current smokers

Abstract: We have confirmed previous observations that smoking quantity was positively associated with hypertension, and the results of our study suggested that the association between smoking and hypertension was probably mediated by CRP.

Cited by 21 publications

References 53 publications

Where there's smoke there might be hypertension

Where there's smoke there might be hypertension

Mediation Role of C-Reactive Protein on the Association between Smoking Quantity and Type 2 Diabetes in Current Chinese Smokers

The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function

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