The association between triglyceride-glucose index, cardio-cerebrovascular diseases, and death in Korean adults: A retrospective study based on the NHIS-HEALS cohort

Kim, Joungyoun; Shin, Sang-Jun; Kang, Hee-Taik

doi:10.1371/journal.pone.0259212

Cited by 25 publications

(32 citation statements)

References 28 publications

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“…In our study, we found similar cut-off values for boys and girls (8.38 vs 8.27). Moreover, similar cut-off values have been reached in a limited number of studies conducted in different countries (7.8-8.65) [15][16][17][18][19][20][21][22][23][24] . Moon et al 20 showed that 12-19 years old 8037 adolescents the cut-off values for the Ty-G index ranged from 8.15-8.65 in Mexican American, Non-Hispanic White, Korean, and Non-Hispanic Black adolescents.…”

Section: Discussionsupporting

confidence: 52%

“…On the other hand, it has an important limitation, because of the cut-off point changed by the pubertal stage. Recently, emerged studies have shown that the Ty-G index can accept as a marker of IR, that is correlated with both the euglycemic clamp test and the HOMA-IR levels [7][8][9] There is a lot of study in adults investigating the Ty-G index [15][16][17][18] . However, a limited study in pediatric age group [19][20][21][22][23][24] .…”

Section: Discussionmentioning

confidence: 99%

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Triglyceride-Glucose Index As a Surrogate Marker for Insulin Resistance ın Obese Adolescents

TAŞTANOĞLU¹,

Çelik²

2021

Cumhuriyet Medical Journal

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There is a lot of study in adults investigating the Triglyceride-Glucose (Ty-G) index. However, a limited study has been searched in the pediatric age group. Moreover, to the best of our knowledge, there is no study on Turkish children. The aim of this study, to investigate the usability of the triglyceride-glucose index as an indicator of insulin resistance in obese adolescents and to calculate the cut-off values.Method: Six hundred twenty-three pubertal obese adolescents (266 boys, and 357 girls) were retrospectively evaluated. Ty-G index and HOMA-IR levels were calculated. ROC analysis was used for the estimations of the Ty-G index cutoff value.Results: There was positive correlation between HOMA-IR and Ty-G index in boys (r=0.255, p<0.001), in girls (r=0.402, p<0.001), and all study groups (r=0.323, p<0.001). Ty-G index cutoff value for insülin resistance in pubertal obese adolescents was calculated as 8.42 with 70.1 % sensitivity and 59.3 % specificity for all study groups; 8,38 with 71.1 % sensitivity, and 48.3 % specificity for boys; 8,27 with 80% sensitivity, and 52.9% specificity for girls.Conclusions: Ty-G index may be a reliable indicator for insülin resistance in pubertal obese adolescents. More attention should be given fort his marker with prospective studies.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Triglyceride-Glucose Index As a Surrogate Marker for Insulin Resistance ın Obese Adolescents

TAŞTANOĞLU¹,

Çelik²

2021

Cumhuriyet Medical Journal

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“…We included four cohort studies with 521,694 participants [ 35 , 36 , 38 , 42 ]. There was no statistically significant association between the TyG index and all-cause mortality (highest vs. lowest: HR = 1.08; 95% CI 0.92–1.27; I2 = 87% or moderate vs. lowest: HR = 0.99; 95% CI 0.81–1.21; I 2 = 65%) (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…This result may highlight the need for a sex-specific management strategy to prevent atherosclerosis. Of our included studies, adjustment for sex was not performed in two [ 35 , 42 ]. Nonetheless, our results showed a higher TyG index to be associated with CAD/CVD, even after deleting sex-unadjusted studies (CVD HR = 1.59, 95% CI 1.21–2.09).…”

Section: Discussionmentioning

confidence: 99%

Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis

Tan

Huang

Zhao

et al. 2022

Cardiovasc Diabetol

153

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Background The triglyceride-glucose (TyG) index is a new alternative measure for insulin resistance. This meta-analysis was conducted to assess the associations of the TyG index with the risks of cardiovascular diseases and mortality in the general population. Methods The PubMed, Cochrane Library and Embase databases were searched for randomized controlled trials or observational cohort studies reporting associations of the TyG index with cardiovascular diseases and mortality from inception to April 16, 2022. Effect sizes were pooled using random-effects models. Robust error meta-regression methods were applied to fit nonlinear dose–response associations. Evidence quality levels and recommendations were assessed using the Grading of Recommendations Assessment, Development and Evaluation system (GRADE). Results Twelve cohort studies (6 prospective and 6 retrospective cohorts) involving 6,354,990 participants were included in this meta-analysis. Compared with the lowest TyG index category, the highest TyG index was related to a higher incidence of coronary artery disease (CAD) (3 studies; hazard ratio [HR] = 2.01; 95% confidence interval [CI] 1.68–2.40; I2 = 0%), myocardial infarction (MI) (2 studies; HR = 1.36; 95% CI 1.18–1.56; I2 = 35%), and composite cardiovascular disease (CVD) (5 studies; HR = 1.46; 95% CI 1.23–1.74; I2 = 82%). However, there was no association between the TyG index and mortality (cardiovascular mortality [3 studies; HR = 1.10; 95% CI 0.82–1.47; I2 = 76%] or all-cause mortality [4 studies; HR = 1.08; 95% CI 0.92–1.27; I2 = 87%]). In the dose–response analysis, there was a linear association of the TyG index with the risk of CAD (Pnonlinear = 0.3807) or CVD (Pnonlinear = 0.0612). GRADE assessment indicated very low certainty for CVD, MI, cardiovascular mortality and all-cause mortality, and moderate certainty for CAD. Conclusions Based on our current evidence, a higher TyG index may be associated with an increased incidence of CAD (moderate certainty), MI (very low certainty) and CVD (very low certainty) in the general population. There is a potential linear association of the TyG index with CAD and the composite CVD incidence. Further prospective studies (especially in non-Asians) are needed to confirm our findings.

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“…Several studies have examined the associations between TyG index and all-cause and cause-specific mortality [ 5 , 6 ]. It has been demonstrated that TyG index was an independent predictor of mortality in patients with type 2 diabetes [ 7 ], hypertension [ 8 ] and stroke [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Association of triglyceride glucose index with all-cause and cause-specific mortality among middle age and elderly US population

et al. 2022

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Aims To investigate the association between the triglyceride glucose (TyG) index and all-cause and cause-specific mortality in middle age and elderly population. Methods and results A total of 9,254 participants with age ≥ 45 years were enrolled from the National Health and Nutrition Examination Survey cycle of 1999–2014. The TyG index was determined as ln [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. Primary outcomes were all-cause mortality and cause-specific mortality (cardiovascular diseases and malignant neoplasms). The association between the levels of TyG and the risk of mortality was explored with Cox regression models. After a median follow-up of 7.6 years, 1,774 all-cause death occurred. Univariate analysis showed that the TyG was associated with all-cause mortality (hazard ratio [HR] 1.18, 95% confidence interval [CI] [1.11,1.26]; p < 0.001). Furthermore, multivariate-adjusted analysis found that the third TyG quartile (8.72 ~ 9.16) was associated with the lowest risk of all-cause mortality (HR 0.84, 95%CI [0.73, 0.98]; p < 0.05). Restricted cubic splines showed that the association between levels of TyG index and the risk of all-cause mortality was non-linear (p for nonlinearity < 0.001) and the inflection point was 9.18 using threshold effect analysis. The HR was 0.82 (95%CI [0.71,0.96]) below 9.18 while the HR was 1.32 (95%CI [1.12,1.55]) above 9.18. Conclusion TyG index was U-shaped associated with all-cause mortality and the TyG index associated with the lowest risk of all-cause mortality was 9.18.

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The association between triglyceride-glucose index, cardio-cerebrovascular diseases, and death in Korean adults: A retrospective study based on the NHIS-HEALS cohort

Cited by 25 publications

References 28 publications

Triglyceride-Glucose Index As a Surrogate Marker for Insulin Resistance ın Obese Adolescents

Triglyceride-Glucose Index As a Surrogate Marker for Insulin Resistance ın Obese Adolescents

Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis

Association of triglyceride glucose index with all-cause and cause-specific mortality among middle age and elderly US population

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